His scientific interests lie mostly in Biochemistry, Crystallin, Lens protein, Oxidative stress and Biophysics. The study incorporates disciplines such as Chromatography and Fluorescence in addition to Biochemistry. His Crystallin research incorporates elements of Disulfide bond, Molecular mass and Serine, Phosphorylation.
His biological study spans a wide range of topics, including Normal values, Beta Carbolines, Cataracts, Chaperone and Normal level. The concepts of his Oxidative stress study are interwoven with issues in Organ culture, Hydroxyl radical, Mechanism of action, Molecular biology and Hydrogen peroxide. His research in Biophysics intersects with topics in Thiol, Lens, Molecular size, Membrane permeability and Fiber cell.
The scientist’s investigation covers issues in Biochemistry, Crystallin, Molecular biology, Lens protein and Lens. Abraham Spector focuses mostly in the field of Biochemistry, narrowing it down to topics relating to Biophysics and, in certain cases, Membrane. The Crystallin study combines topics in areas such as Size-exclusion chromatography, Crystallography, Molecular mass, Isoelectric focusing and Phosphorylation.
In his study, Cell biology is inextricably linked to Gene expression, which falls within the broad field of Molecular biology. His Lens protein research includes elements of Chromatography and Fluorescence. His study in Oxidative stress is interdisciplinary in nature, drawing from both Knockout mouse and Hydrogen peroxide.
Cell biology, Molecular biology, Catalase, Oxidative stress and Cell culture are his primary areas of study. His Molecular biology study combines topics in areas such as Gene chip analysis, Real-time polymerase chain reaction, Knockout mouse and Antioxidant. His studies in Catalase integrate themes in fields like Cell, Gene targeting, Transgene and Hydrogen peroxide.
In the subject of general Oxidative stress, his work in Glutathione peroxidase is often linked to Lung disease, thereby combining diverse domains of study. The various areas that Abraham Spector examines in his Cell culture study include Gene expression, DNA damage, Glutathione, Biochemistry and Programmed cell death. His research combines Biophysics and Biochemistry.
Abraham Spector focuses on Catalase, Molecular biology, Cell culture, Biochemistry and Oxidative stress. In general Catalase study, his work on Glutathione peroxidase often relates to the realm of Population, thereby connecting several areas of interest. His Cell culture study which covers Glutathione that intersects with Programmed cell death, Poly ADP ribose polymerase, DNA damage, Reactive oxygen species and NAD+ kinase.
His study in Enzyme, Crystallin, Heat shock protein, Stress Proteins and Phosphorylation is carried out as part of his Biochemistry studies. His Enzyme study combines topics from a wide range of disciplines, such as Luciferase, HSP60, Chaperone and Lens protein. His Oxidative stress research incorporates themes from Diabetes mellitus, Disease, Pathology and Bioinformatics.
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Oxidative stress-induced cataract: mechanism of action.
The FASEB Journal (1995)
Hydrogen peroxide and human cataract.
Abraham Spector;William H. Garner.
Experimental Eye Research (1981)
Development of synthetic compounds with glutathione peroxidase activity
Stephen R. Wilson;Paul A. Zucker;Ruey Ruey C. Huang;Abraham Spector.
Journal of the American Chemical Society (1989)
Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury.
Ye Shih Ho;Ye Xiong;Wanchao Ma;Abraham Spector.
Journal of Biological Chemistry (2004)
Selective oxidation of cysteine and methionine in normal and senile cataractous lenses
Margaret H. Garner;Abraham Spector.
Proceedings of the National Academy of Sciences of the United States of America (1980)
REVIEW: OXIDATIVE STRESS AND DISEASE
Journal of Ocular Pharmacology and Therapeutics (2000)
The effect of H2O2 upon thioredoxin-enriched lens epithelial cells.
A. Spector;Guo-Zai Yan;R.-R. C. Huang;M. J. Mcdermott.
Journal of Biological Chemistry (1988)
The chaperone activity of bovine alpha crystallin. Interaction with other lens crystallins in native and denatured states.
Keyang Wang;A. Spector.
Journal of Biological Chemistry (1994)
α-Crystallin. The isolation and characterization of distinct macromolecular fractions
Abraham Spector;Lu-Ku Li;Robert C. Augusteyn;Arthur Schneider.
Biochemical Journal (1971)
cAMP-dependent phosphorylation of bovine lens alpha-crystallin.
Abraham Spector;Raul Chiesa;Janet Sredy;William Garner.
Proceedings of the National Academy of Sciences of the United States of America (1985)
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