World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
16554
World Ranking
8191
National Ranking
253

Overview

Zhi-Nan Chen is affiliated with the Air Force Medical University in China. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant work also in Medicine. Specific subfields of study include Molecular Biology, Immunology, Oncology, Cancer Research, and Infectious Diseases.

The scientist's work addresses several key topics, including:

  • Signaling Pathways in Disease
  • RNA modifications and cancer
  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • Cancer Immunotherapy and Biomarkers
  • COVID-19 Clinical Research Studies
  • Ferroptosis and cancer prognosis

Frequent publication venues highlight the platforms where their research appears most often. These include Signal Transduction and Targeted Therapy, MedComm, Frontiers in Immunology, Research Square, and the International Journal of Molecular Sciences.

Several papers authored or co-authored by Zhi-Nan Chen demonstrate the scope and focus of their research. Notable recent publications include:

  • "CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells" (2020), Signal Transduction and Targeted Therapy
  • "SARS-CoV-2 invades host cells via a novel route: CD147-spike protein" (2020), bioRxiv (Cold Spring Harbor Laboratory)
  • "TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models" (2022), Nature Communications
  • "Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model" (2022), Redox Biology
  • "Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial" (2020), bioRxiv (Cold Spring Harbor Laboratory)

These publications show a transition from infectious disease research related to SARS-CoV-2 to mechanistic studies on ferroptosis and inflammation in disease models.

Zhi-Nan Chen frequently collaborates with several researchers, indicating a network of co-authorship in their scientific community. Frequent co-authors include Huijie Bian, Xiuxuan Sun, Ruo Chen, Gang Nan, and Jian-Li Jiang.

Best Publications

  • CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells.

    Ke Wang;Wei Chen;Zheng Zhang;Yongqiang Deng

  • Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

    Jiao Wu;Jiao Wu;Alexander M. Minikes;Alexander M. Minikes;Minghui Gao;Minghui Gao;Huijie Bian

  • SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

    Ke Wang;Wei Chen;Yu-Sen Zhou;Jian-Qi Lian

  • New insights into the roles of CHOP-induced apoptosis in ER stress.

    Yiming Li;Yunshan Guo;Juan Tang;Jianli Jiang

  • Function of HAb18G/CD147 in Invasion of Host Cells by Severe Acute Respiratory Syndrome Coronavirus

    Zhinan Chen;Li Mi;Jing Xu;Jiyun Yu

  • MicroRNA Let-7a Inhibits Proliferation of Human Prostate Cancer Cells In Vitro and In Vivo by Targeting E2F2 and CCND2

    Qingchuan Dong;Ping Meng;Tao Wang;Weiwei Qin

  • A randomized controlled trial of Licartin for preventing hepatoma recurrence after liver transplantation.

    Jing Xu;Zhong-Yang Shen;Xin-Guo Chen;Qing Zhang

  • CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways.

    Jibin Li;Qichao Huang;Xiaoyu Long;Jing Zhang

  • HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma.

    Jing Xu;Hui-Yun Xu;Qing Zhang;Fei Song

  • Cyclophilin A up-regulates MMP-9 expression and adhesion of monocytes/macrophages via CD147 signalling pathway in rheumatoid arthritis

    Y. Yang;N. Lu;J. Zhou;Z.-n. Chen

  • Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection : Clinical phase I/II trials

    Zhi-Nan Chen;Li Mi;Jing Xu;Fei Song

  • HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-β signaling and is transcriptionally regulated by Slug.

    Wu J;Ru Ny;Zhang Y;Li Y

  • MicroRNA expression signatures in Barrett's esophagus and esophageal adenocarcinoma.

    Hushan Yang;Jian Gu;Kenneth K. Wang;Wei Zhang

  • CD147 promotes reprogramming of glucose metabolism and cell proliferation in HCC cells by inhibiting the p53-dependent signaling pathway

    Qichao Huang;Jibin Li;Jinliang Xing;Weiwei Li

  • Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial

    Huijie Bian;Zhao-Hui Zheng;Ding Wei;Zheng Zhang

  • Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion.

    Xiao-Ling Yu;Tiancen Hu;Jia-Mu Du;Jian-Ping Ding

  • Mechanism of DNA translocation underlying chromatin remodelling by Snf2.

    M. Li;X. Xia;Y. Tian;Q. Jia

  • Transcription factor Sp1 regulates expression of cancer‐associated molecule CD147 in human lung cancer

    Ling-Min Kong;Cheng-Gong Liao;Fei Fei;Xu Guo

  • A regulatory loop involving miR-22, Sp1, and c-Myc modulates CD147 expression in breast cancer invasion and metastasis.

    Ling-Min Kong;Cheng-Gong Liao;Yang Zhang;Jing Xu

  • Publisher Correction: Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling.

    Jiao Wu;Jiao Wu;Alexander M. Minikes;Alexander M. Minikes;Minghui Gao;Minghui Gao;Huijie Bian

Frequent Co-Authors

Jinliang Xing
Jinliang Xing Air Force Medical University
Shijie Wang
Shijie Wang Agency for Science, Technology and Research
Albert Sickmann
Albert Sickmann Leibniz Institute for Neurobiology
Xinyuan Liu
Xinyuan Liu Southern University of Science and Technology
Jian Gu
Jian Gu The University of Texas MD Anderson Cancer Center
Wei Zhang
Wei Zhang Central South University
Connie R. Jimenez
Connie R. Jimenez Vrije Universiteit Amsterdam
Yong-Qiang Deng
Yong-Qiang Deng Academy of Military Medical Sciences
Sander R. Piersma
Sander R. Piersma VU University Medical Center

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