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Biology and Biochemistry

D-Index
57
Citations
13105
World Ranking
13718
National Ranking
418

Overview

Hsiao Chang Chan is affiliated with the Chinese University of Hong Kong in China. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with a notable emphasis on pulmonary and respiratory medicine as well as molecular biology and reproductive medicine.

The scientist's work covers key topics including cystic fibrosis research advances, ion channel regulation and function, neonatal respiratory health research, esophageal and gastrointestinal pathology, magnesium in health and disease, Kruppel-like factors research, and hypothalamic control of reproductive hormones.

Recent publications by Hsiao Chang Chan include:

  • Magnesium implantation or supplementation ameliorates bone disorder in CFTR-mutant mice through an ATF4-dependent Wnt/β-catenin signaling, 2021, Bioactive Materials
  • CFTR promotes malignant glioma development via up-regulation of Akt/Bcl2-mediated anti-apoptosis pathway, 2020, Journal of Cellular and Molecular Medicine
  • Involvement of kisspeptin in androgen-induced hypothalamic endoplasmic reticulum stress and its rescuing effect in PCOS rats, 2021, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  • β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility, 2022, Cell Reports Medicine
  • High cystic fibrosis transmembrane conductance regulator expression in childhood B-cell acute lymphoblastic leukemia acts as a potential therapeutic target, 2022, Translational Cancer Research

The scholar has collaborated frequently with colleagues including Ye Chun Ruan, Jieting Zhang, Peijie Hu, Xiaohu Zhang, and Jinghui Guo. Their articles have been published in venues such as Bioactive Materials, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Cell Reports Medicine, Journal of Cellular and Molecular Medicine, and Translational Cancer Research.

Best Publications

  • Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats

    Yifeng Zhang;Jiankun Xu;Ye Chun Ruan;Mei Kuen Yu

  • Mesoscopic study of concrete I: generation of random aggregate structure and finite element mesh

    Z.M. Wang;A.K.H. Kwan;H.C. Chan

  • Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

    Guangwu Guo;Xiaojuan Sun;Chao Chen;Song Wu

  • An epididymis-specific beta-defensin is important for the initiation of sperm maturation.

    Chen Xi Zhou;Yong-Lian Zhang;Liqing Xiao;Min Zheng

  • An Antimicrobial Peptide Gene Found in the Male Reproductive System of Rats

    Peng Li;Hsiao Chang Chan;Bin He;Siu Cheung So

  • Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility.

    Wen Ming Xu;Qi Xian Shi;Wen Ying Chen;Chen Xi Zhou

  • Mesoscopic study of concrete II: nonlinear finite element analysis

    A.K.H. Kwan;Z.M. Wang;H.C. Chan

  • Activation of the epithelial Na+ channel triggers prostaglandin E₂ release and production required for embryo implantation.

    Ye Chun Ruan;Jing Hui Guo;Xinmei Liu;Runju Zhang

  • Regulation of male fertility by CFTR and implications in male infertility

    Hui Chen;Ye Chun Ruan;Wen Ming Xu;Jing Chen;Jing Chen

  • Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm.

    Xiao Fei Wang;Chen Xi Zhou;Qi Xian Shi;Yu Ying Yuan

  • Identification of testis development and spermatogenesis-related genes in human and mouse testes using cDNA arrays

    Jiahao Sha;Zuomin Zhou;Jianmin Li;Lanlan Yin

  • The Involvement of HAb18G/CD147 in Regulation of Store-operated Calcium Entry and Metastasis of Human Hepatoma Cells

    Jian Li Jiang;Jian Li Jiang;Qing Zhou;Mei Kuen Yu;Lok Sze Ho

  • FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca(2+)/CREB pathway.

    Xin‐Mei Liu;Hsiao Chang Chan;Guo‐Lian Ding;Guo‐Lian Ding;Guo‐Lian Ding;Jie Cai

  • Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR

    Jing Hui Guo;Hui Chen;Ye Chun Ruan;Ye Chun Ruan;Xue Lian Zhang

  • The cystic fibrosis transmembrane conductance regulator in reproductive health and disease

    Hsiao Chang Chan;Ye Chun Ruan;Qiong He;Min Hui Chen

  • Distribution and regulation of ENaC subunit and CFTR mRNA expression in murine female reproductive tract.

    L.N. Chan;L.L. Tsang;D.K. Rowlands;L.G. Rochelle

  • A role for annexin IV in epithelial cell function. Inhibition of calcium-activated chloride conductance.

    M. A. Kaetzel;Hsiao Chang Chan;W. P. Dubinsky;J. R. Dedman

  • CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer

    C. Xie;X. H. Jiang;X. H. Jiang;J. T. Zhang;T. T. Sun

  • Annexin IV inhibits calmodulin-dependent protein kinase II-activated chloride conductance. A novel mechanism for ion channel regulation.

    Hsiao Chang Chan;M. A. Kaetzel;A. L. Gotter;J. R. Dedman

  • Purinergic regulation of anion secretion by cystic fibrosis pancreatic duct cells.

    H. C. Chan;W. T. Cheung;P. Y. Leung;L. J. Wu

Frequent Co-Authors

Po Sing Leung
Po Sing Leung Chinese University of Hong Kong
Hao Chen
Hao Chen Chinese University of Hong Kong
Rui Chen
Rui Chen Capital Medical University
Gang Li
Gang Li Chinese University of Hong Kong
Joseph H.W. Lee
Joseph H.W. Lee Hong Kong Polytechnic University
Jiahao Sha
Jiahao Sha Nanjing Medical University
Paul K.S. Chan
Paul K.S. Chan Chinese University of Hong Kong
Wen Guo Jiang
Wen Guo Jiang Cardiff University
Zhi-Nan Chen
Zhi-Nan Chen Air Force Medical University
Ling Qin
Ling Qin Chinese University of Hong Kong

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