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Yannick Jacques

Yannick Jacques

Overview

Yannick Jacques is affiliated with the University of Nantes in France and has contributed to research primarily in the fields of Medicine and Immunology and Microbiology. Their work often focuses on immunology, infectious diseases, radiology, nuclear medicine and imaging, as well as dermatology.

Their research spans a variety of topics, including:

  • Immune Cell Function and Interaction
  • SARS-CoV-2 and COVID-19 Research
  • Viral gastroenteritis research and epidemiology
  • Monoclonal and Polyclonal Antibodies Research
  • IL-33, ST2, and ILC Pathways
  • T-cell and B-cell Immunology
  • Toxin Mechanisms and Immunotoxins

Yannick Jacques has authored several papers in notable scientific journals. Some of their recent publications include:

  • IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: implications for antimetastatic treatment, 2020, Journal for ImmunoTherapy of Cancer
  • High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2, 2021, European Journal of Immunology
  • Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation, 2022, Frontiers in Immunology
  • High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Their frequent co-authors include Bernard Vanhove, Odile Duvaux, Juliette Rousse, Pierre-Joseph Royer, and Gwénaëlle Evanno, each having collaborated on multiple occasions. They have published multiple articles in venues such as Journal for ImmunoTherapy of Cancer, European Journal of Immunology, Frontiers in Immunology, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.

    Nicholas D. Huntington;Nicolas Legrand;Nuno L. Alves;Barbara Jaron

  • Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor

    Thierry Walzer;Laura Chiossone;Julie Chaix;Andrew Calver

  • Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins.

    Erwan Mortier;Agnès Quéméner;Agnès Quéméner;Patricia Vusio;Inken Lorenzen

  • Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling

    Yoshlaki Nakamura;Sarah M. Russell;Sarah A. Mess;Sarah A. Mess;Michael Friedmann

  • Randomized Controlled Trial of a Monoclonal Antibody against the Interleukin-2 Receptor (33B3.1) as Compared with Rabbit Antithymocyte Globulin for Prophylaxis against Rejection of Renal Allografts

    J P Soulillou;D Cantarovich;B Le Mauff;M Giral

  • Natural, Proteolytic Release of a Soluble Form of Human IL-15 Receptor α-Chain That Behaves as a Specific, High Affinity IL-15 Antagonist

    Erwan Mortier;Jérôme Bernard;Ariane Plet;Yannick Jacques

  • High antitumor activity of RLI, an interleukin-15 (IL-15)–IL-15 receptor α fusion protein, in metastatic melanoma and colorectal cancer

    Anne Bessard;Véronique Solé;Grégory Bouchaud;Agnès Quéméner

  • PREVENTION OF REJECTION OF KIDNEY TRANSPLANTS BY MONOCLONAL ANTIBODY DIRECTED AGAINST INTERLEUKIN 2

    J.P. Soulillou;B. Le Mauff;D. Olive;M. Delaage

  • Effect of anti-LFA1 (CD11a) monoclonal antibodies in acute rejection in human kidney transplantation.

    Brigitte Le Mauff;Maryvonne Hourmant;Jean-philippe Rougier;Michel Hirn

  • Close phenotypic and functional similarities between human and murine alphabeta T cells expressing invariant TCR alpha-chains.

    François Davodeau;Marie Alix Peyrat;Antje Necker;Roberto Dominici

  • The soluble alpha chain of interleukin-15 receptor: a proinflammatory molecule associated with tumor progression in head and neck cancer.

    Cécile Badoual;Grégory Bouchaud;Nour El Houda Agueznay;Erwan Mortier

  • Natural Splicing of Exon 2 of Human Interleukin-15 Receptor α-Chain mRNA Results in a Shortened Form with a Distinct Pattern of Expression

    Sigrid Dubois;Florence Magrangeas;Philippe Lehours;Sylvie Raher

  • A soluble interleukin 2 receptor produced by a normal alloreactive human T cell clone binds interleukin 2 with low affinity.

    Y Jacques;B Le Mauff;F Boeffard;A Godard

  • Tumor targeting of the IL‐15 superagonist RLI by an anti‐GD2 antibody strongly enhances its antitumor potency

    Marie Vincent;Anne Bessard;Denis Cochonneau;Géraldine Teppaz

  • Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11

    Michel Cherel;Michel Sorel;Benoît Lebeau;Sigrid Dubois

  • Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Mediates Internalization and Degradation of Leukemia Inhibitory Factor but Not Signal Transduction

    Frédéric Blanchard;Laurence Duplomb;Sylvie Raher;Patricia Vusio

  • Identification of an Interleukin-15α Receptor-binding Site on Human Interleukin-15

    Jérôme Bernard;Catherine Harb;Erwan Mortier;Agnès Quéméner

  • Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells - Implication for the production of multidomain proteins during evolution

    Florence Magrangeas;Gilles Pitiot;Sigrid Dubois;Elisabeth Bragado-Nilsson

  • A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130

    Stefan Pflanz;Ingrid Tacken;Joachim Grötzinger;Yannick Jacques

  • The mannose 6-phosphate/insulin-like growth factor II receptor is a nanomolar affinity receptor for glycosylated human leukemia inhibitory factor.

    Frédéric Blanchard;Sylvie Raher;Laurence Duplomb;Patricia Vusio

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