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Neuroscience

D-Index
42
Citations
7975
World Ranking
7603
National Ranking
222

Overview

Timothy W. Bredy is affiliated with the University of Queensland in Australia and focuses their research primarily in the field of Biochemistry, Genetics, and Molecular Biology. Their work spans multiple subfields, including Molecular Biology, Cancer Research, Cellular and Molecular Neuroscience, Cognitive Neuroscience, and Social Psychology.

The research topics covered by Bredy's publications emphasize RNA-related mechanisms and their role in disease and cellular functions. Major thematic areas include:

  • RNA Research and Splicing
  • Cancer-related molecular mechanisms research
  • RNA modifications and cancer
  • Circular RNAs in diseases
  • RNA regulation and disease
  • MicroRNA in disease regulation
  • RNA and protein synthesis mechanisms

Timothy W. Bredy has contributed to a variety of peer-reviewed articles, with recent publications including:

  • "RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain" (2020) published in Trends in Neurosciences
  • "ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3" (2022) published in Cell Reports
  • "From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health" (2021) published in Journal of Neuroscience
  • "Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction" (2020) published in Nature Neuroscience
  • "Fear extinction is regulated by the activity of long noncoding RNAs at the synapse" (2023) published in Nature Communications

Bredy has frequently collaborated with several researchers, including:

  • Qiongyi Zhao
  • Wei-Siang Liau
  • Paul R. Marshall
  • Laura J. Leighton
  • Sachithrani U. Madugalle

Publication venues where Bredy has regularly contributed include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Neuroscience
  • Nature Neuroscience
  • Neurobiology of Learning and Memory
  • Cell Reports

Best Publications

  • Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear

    Timothy W. Bredy;Hao Wu;Cortney Crego;Jessica Zellhoefer

  • Epigenetic Programming of Stress Responses through Variations in Maternal Care

    Eric W. Fish;Dara Shahrokh;Rose Bagot;Christian Caldji

  • The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing.

    Guy Barry;J. A. Briggs;D. P. Vanichkina;E. M. Poth

  • The amygdala and medial prefrontal cortex: partners in the fear circuit

    Roger Marek;Cornelia Strobel;Timothy W. Bredy;Pankaj Sah

  • Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

    Monica D. Bjørge;Gunn A. Hildrestrand;Katja Scheffler;Katja Scheffler;Rajikala Suganthan

  • Partial reversal of the effect of maternal care on cognitive function through environmental enrichment.

    T.W Bredy;R.A Humpartzoomian;D.P Cain;M.J Meaney

  • The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear

    Timothy W. Bredy;Mark Barad

  • Maternal care influences neuronal survival in the hippocampus of the rat.

    Timothy W. Bredy;Rebecca J. Grant;Danielle L. Champagne;Michael J. Meaney

  • Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice

    Jocelyn Widagdo;Qiong-Yi Zhao;Marie-Jeanne Kempen;Men Chee Tan

  • Peripubertal environmental enrichment reverses the effects of maternal care on hippocampal development and glutamate receptor subunit expression.

    Timothy W. Bredy;Tie Yuan Zhang;Rebecca J. Grant;Josie Diorio

  • Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders.

    Kevin J. Dudley;Xiang Li;Michael S. Kobor;Tod E. Kippin

  • Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring.

    A.K. Short;K.A. Fennell;K.A. Fennell;Victoria M Perreau;A. Fox

  • The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory

    Quan Lin;Wei Wei;Carlos M. Coelho;Xiang Li

  • Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation

    Xiang Li;Wei Wei;Qiong-Yi Zhao;Jocelyn Widagdo

  • MicroRNA regulation of neural plasticity and memory.

    Timothy W. Bredy;Quan Lin;Wei Wei;Danay Baker-Andresen

  • Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation.

    Danay Baker-Andresen;Vikram S. Ratnu;Timothy W. Bredy

  • Maternal programming of defensive responses through sustained effects on gene expression

    Tie-Yuan Zhang;Rose Bagot;Carine Parent;Cathy Nesbitt

  • Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain.

    Vikram S. Ratnu;Michael R. Emami;Timothy W. Bredy

  • Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated With Anxiety-like Behavior in Mice

    Paola A. Spadaro;Charlotte R. Flavell;Jocelyn Widagdo;Vikram S. Ratnu

  • Effect of neonatal handling and paternal care on offspring cognitive development in the monogamous California mouse (Peromyscus californicus).

    Timothy W Bredy;Anna W Lee;Michael J Meaney;Richard E Brown

  • Paternal deprivation during infancy results in dendrite- and time-specific changes of dendritic development and spine formation in the orbitofrontal cortex of the biparental rodent Octodon degus.

    C. Helmeke;K. Seidel;G. Poeggel;T.W. Bredy

Frequent Co-Authors

Rodrigo Grassi-Oliveira
Rodrigo Grassi-Oliveira Pontifical Catholic University of Rio Grande do Sul
John S. Mattick
John S. Mattick University of New South Wales
Michael S. Kobor
Michael S. Kobor University of British Columbia
Pankaj Sah
Pankaj Sah University of Queensland
Anthony J. Hannan
Anthony J. Hannan Florey Institute of Neuroscience and Mental Health
Nicolas Singewald
Nicolas Singewald University of Innsbruck
Marcelo A. Wood
Marcelo A. Wood University of California, Irvine
Boyer D. Winters
Boyer D. Winters University of Guelph
Robert K. P. Sullivan
Robert K. P. Sullivan University of Queensland
Tim R. Mercer
Tim R. Mercer Garvan Institute of Medical Research

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