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Neuroscience

D-Index
44
Citations
23441
World Ranking
7025
National Ranking
3025

Overview

Takahiro Takano is affiliated with the University of Rochester in the United States. Their research spans several interconnected fields, primarily focusing on biochemistry, genetics, molecular biology, medicine, and neuroscience. In particular, Takano's work concentrates on molecular biology, sensory systems, physiology, immunology, and cellular and molecular neuroscience.

Their scientific contributions cover a range of topics, including:

  • Ion channels and receptors
  • Ion channel regulation and function
  • Salivary gland disorders and functions
  • Connexins and lens biology
  • Lipid membrane structure and behavior
  • Neurobiology and insect physiology research
  • Calcium signaling and nucleotide metabolism

Takano has published research in prominent scientific journals. Their recent papers include:

  • "Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice," 2020, The Journal of General Physiology
  • "Highly localized intracellular Ca2+ signals promote optimal salivary gland fluid secretion," 2021, eLife
  • "Targeting Synovial Lymphatic Function as a Novel Therapeutic Intervention for Age-Related Osteoarthritis in Mice," 2023, Arthritis & Rheumatology
  • "Ca2+ signals in pancreatic acinar cells in response to physiological stimulation in vivo," 2023, The Journal of Physiology
  • "In vivo Ca2+ Imaging in Mouse Salivary Glands," 2022, BIO-PROTOCOL

The majority of Takano's publications appear in journals such as The Journal of Physiology, eLife, bioRxiv (Cold Spring Harbor Laboratory), The Journal of General Physiology, and Arthritis & Rheumatology.

Frequent collaborators include:

  • David I. Yule
  • Kai-Ting Huang
  • Larry E. Wagner
  • Amanda M. Wahl
  • James Sneyd

Takano's research addresses fundamental mechanisms of calcium signaling, ion channel function, and fluid secretion, contributing to a broad understanding of cellular and physiological processes in various organ systems. Their interdisciplinary approach bridges molecular biology and physiology, with significant implications for understanding gland function and ion channel regulation.

Best Publications

  • Sleep Drives Metabolite Clearance From the Adult Brain

    Lulu Xie;Hongyi Kang;Qiwu Xu;Michael J. Chen

  • Uniquely hominid features of adult human astrocytes

    Nancy Ann Oberheim;Takahiro Takano;Xiaoning Han;Wei He

  • Astrocyte-mediated control of cerebral blood flow.

    Takahiro Takano;Guo-Feng Tian;Weiguo Peng;Nanhong Lou

  • Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture

    Nanna Goldman;Michael Chen;Takumi Fujita;Qiwu Xu

  • An astrocytic basis of epilepsy

    Guo-Feng Tian;Hooman Azmi;Takahiro Takano;Qiwu Xu

  • Glutamate release promotes growth of malignant gliomas.

    Takahiro Takano;Jane H.-C. Lin;Gregory Arcuino;Qun Gao

  • Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo.

    Xiaohai Wang;Nanhong Lou;Qiwu Xu;Guo-Feng Tian

  • Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice

    Xiaoning Han;Michael Chen;Fushun Wang;Martha Windrem

  • Signaling at the Gliovascular Interface

    Marie Simard;Gregory Arcuino;Takahiro Takano;Qing Song Liu

  • Cortical spreading depression causes and coincides with tissue hypoxia

    Takahiro Takano;Guo-Feng Tian;Weiguo Peng;Nanhong Lou

  • Beyond the role of glutamate as a neurotransmitter

    Takahiro Takano;Anker J. Hansen

  • P2X7 receptor inhibition improves recovery after spinal cord injury.

    Xiaohai Wang;Gregory Arcuino;Takahiro Takano;Jane Lin

  • The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex.

    Ditte Lovatt;Ursula Sonnewald;Helle S. Waagepetersen;Arne Schousboe

  • Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

    Weiguo Peng;Maria L. Cotrina;Xiaoning Han;Hongmei Yu

  • Intercellular calcium signaling mediated by point-source burst release of ATP

    Gregory Arcuino;Jane H.-C. Lin;Takahiro Takano;Collins Liu

  • Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

    Iben Lundgaard;Baoman Li;Lulu Xie;Hongyi Kang

  • Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier

    Nanhong Lou;Takahiro Takano;Yong Pei;Anna L. Xavier

  • Astrocytes and ischemic injury.

    Takahiro Takano;NancyAnn Oberheim;Maria Luisa Cotrina

  • Loss of Astrocytic Domain Organization in the Epileptic Brain

    Nancy Ann Oberheim;Guo Feng Tian;Xiaoning Han;Weiguo Peng

  • Astrocytes Modulate Neural Network Activity by Ca2+-Dependent Uptake of Extracellular K+

    Fushun Wang;Nathan A. Smith;Qiwu Xu;Takumi Fujita

  • Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity

    Ditte Lovatt;Qiwu Xu;Wei Liu;Takahiro Takano

  • Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor.

    Lane Bekar;Witold Libionka;Guo-Feng Tian;Qiwu Xu

Frequent Co-Authors

Steven A. Goldman
Steven A. Goldman University of Rochester Medical Center
Ole Petter Ottersen
Ole Petter Ottersen University of Oslo
Erlend A. Nagelhus
Erlend A. Nagelhus University of Oslo
Bruce R. Ransom
Bruce R. Ransom University of Washington
Berislav V. Zlokovic
Berislav V. Zlokovic University of Southern California
Qing-song Liu
Qing-song Liu Medical College of Wisconsin
Jiang-Fan Chen
Jiang-Fan Chen Boston University
Gerald A. Dienel
Gerald A. Dienel University of Arkansas for Medical Sciences
Michael V. L. Bennett
Michael V. L. Bennett Albert Einstein College of Medicine
Martha E. Bickford
Martha E. Bickford University of Louisville

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