World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
46
Citations
6211
World Ranking
16199
National Ranking
4036

Research.com Recognitions

  • 1996 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Paul B. Hopkins is affiliated with the University of Washington in the United States. Their research spans multiple fields within medicine, biochemistry, genetics, and molecular biology, further specializing in subfields such as molecular biology, physiology, psychiatry and mental health, oncology, and immunology.

The primary topics addressed in their work include Alzheimer's disease research and treatments, dementia and cognitive impairment research, PARP inhibition in cancer therapy, toxin mechanisms and immunotoxins, cell death mechanisms and regulation, mitochondrial function and pathology, and cholinesterase and neurodegenerative diseases.

Recent scholarly contributions comprise the following papers:

  • Structural basis of tankyrase activation by polymerization, 2022, Nature
  • TMCC2 Associates with Alzheimer's Disease Pathology in the Human Brain, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • Transmembrane and coiled-coil 2 associates with Alzheimer's disease pathology in the human brain, 2024, Brain Pathology

Paul B. Hopkins has collaborated frequently with several researchers, including:

  • Claire Troakes
  • Andrew King
  • Guy Tear
  • Nisha Pillay
  • Laura Mariotti

Their publications commonly appear in venues such as:

  • Nature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain Pathology

Paul B. Hopkins received recognition as a Fellow of the American Association for the Advancement of Science (AAAS) in 1996.

Best Publications

  • Solution Structure of a Cisplatin-Induced DNA Interstrand Cross-Link

    Huifang Huang;Leiming Zhu;Brian R. Reid;Gary P. Drobny

  • Metal ion enhanced helicity in synthetic peptides containing unnatural, metal-ligating residues

    Fuqiang Ruan;Yanqiu Chen;Paul B. Hopkins

  • Chlorosulfenylation-dehydrochlorination reactions. New and improved methodology for the synthesis of unsaturated aryl sulfides and aryl sulfones

    Paul B. Hopkins;Philip L. Fuchs

  • TOTAL SYNTHESIS OF ERYTHROMYCINS. 5. TOTAL SYNTHESIS OF ERYTHRONOLIDE A

    E. J. Corey;P. B. Hopkins;S. Kim;S. Yoo

  • A mild procedure for the conversion of 1,2-diols to olefins

    E.J. Corey;B. Hopkins

  • Diisopropylsilyl ditriflate and di--butysilyl ditriflate: new reagents for the protection of diols

    E.J. Corey;Paul B. Hopkins

  • DNA interstrand cross-linking reactions of pyrrole-derived, bifunctional electrophiles: evidence for a common target site in DNA

    Jinsuk Woo;Snorri T. Sigurdsson;Paul B. Hopkins

  • Covalent structure of a nitrogen mustard-induced DNA interstrand cross-link: an N7-to-N7 linkage of deoxyguanosine residues at the duplex sequence 5'-d(GNC)

    Stacia M. Rink;Marjorie S. Solomon;Matthew J. Taylor;Sharanabasava B. Rajur

  • Mechlorethamine cross-links deoxyguanosine residues at 5'-GNC sequences in duplex DNA fragments

    Julie T. Millard;Stanley Raucher;Paul B. Hopkins

  • A rigid and nonperturbing probe for duplex DNA motion

    Andreas. Spaltenstein;Bruce H. Robinson;Paul B. Hopkins

  • Direct demonstration in synthetic oligonucleotides that N,N'-bis(2-chloroethyl)-nitrosourea cross links N1 of deoxyguanosine to N3 of deoxycytidine on opposite strands of duplex DNA.

    Paula L. Fischhaber;Anna S. Gall;James A. Duncan;Paul B. Hopkins

  • Sequence- and structure-dependent DNA base dynamics: synthesis, structure, and dynamics of site, and sequence specifically spin-labeled DNA

    Andreas Spaltenstein;Bruce H. Robinson;Paul B. Hopkins

  • Allylic selenides in organic synthesis: new methods for the synthesis of allylic amines

    Regan G. Shea;Jeffrey N. Fitzner;John E. Fankhauser;Andreas Spaltenstein

  • A Stereocontrolled and effective synthesis of leukotriene B (1).

    E.J. Corey;Anthony Marfat;John Munroe;Kwan Soo Kim

  • Chemical Synthesis and Preliminary Structural Characterization of a Nitrous Acid Interstrand Cross-Linked Duplex DNA

    Eric A. Harwood;Snorri Th. Sigurdsson;N. B. Fredrik Edfeldt;and Brian R. Reid

  • New approaches to the synthesis of trans-alkene isosteres of dipeptides

    Andreas Spaltenstein;Philip A. Carpino;Fumio Miyake;Paul B. Hopkins

  • Interstrand cross-linking of duplex DNA by nitrous acid: covalent structure of the dG-to-dG cross-link at the sequence 5'-CG

    James J. Kirchner;Snorri T. Sigurdsson;Paul B. Hopkins

  • A mechlorethamine-induced DNA interstrand cross-link bends duplex DNA.

    Stacia M. Rink;Paul B. Hopkins

  • Sequence preferences of DNA interstrand cross-linking agents: Importance of minimal DNA structural reorganization in the cross-linking reactions of mechlorethamine, cisplatin and mitomycin C

    Paul B. Hopkins;Julie T. Millard;Jinsuk Woo;Margaret F. Weidner

  • Flexibility of duplex DNA on the submicrosecond timescale.

    T.M. Okonogi;A.W. Reese;S.C. Alley;S.C. Alley;P.B. Hopkins

  • Sequence-Dependent Dynamics of Duplex DNA: The Applicability of a Dinucleotide Model

    T.M. Okonogi;S.C. Alley;A.W. Reese;P.B. Hopkins

Frequent Co-Authors

Snorri Th. Sigurdsson
Snorri Th. Sigurdsson University of Iceland
Bruce H. Robinson
Bruce H. Robinson University of Washington
Bennett M. Shapiro
Bennett M. Shapiro VBL Therapeutics
Rachel E. Klevit
Rachel E. Klevit University of Washington
E. J. Corey
E. J. Corey Harvard University
Michael H. Gelb
Michael H. Gelb University of Washington
Larry W. McLaughlin
Larry W. McLaughlin Boston College
Philip L. Fuchs
Philip L. Fuchs Purdue University West Lafayette
Robert M. Williams
Robert M. Williams Colorado State University
Gary P. Drobny
Gary P. Drobny University of Washington

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