Martin D. Ryan

Overview

Best Publications

• Analysis of the aphthovirus 2A/2B polyprotein 'cleavage' mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal 'skip'.

  Michelle L. L. Donnelly;Garry Luke;Amit Mehrotra;Xuejun Li

  971
  Citations

• The 'cleavage' activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring '2A-like' sequences.

  Michelle L. L. Donnelly;Lorraine E. Hughes;Garry Luke;Heidi Mendoza

  686
  Citations

• Cleavage of foot-and-mouth disease virus polyprotein is mediated by residues located within a 19 amino acid sequence.

  Martin D. Ryan;Andrew M. Q. King;G. Paul Thomas

  602
  Citations

• Foot-and-mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein.

  M D Ryan;J Drew

  517
  Citations

• E unum pluribus: multiple proteins from a self-processing polyprotein

  Pablo de Felipe;Garry A. Luke;Lorraine E. Hughes;David Gani

  469
  Citations

• Virus-encoded proteinases of the picornavirus super-group.

  Martin D. Ryan;Mike Flint

  328
  Citations

• Differentiating infection from vaccination in foot-and-mouth disease using a panel of recombinant, non-structural proteins in ELISA

  D. K. J. Mackay;M. A. Forsyth;P. R. Davies;A. Berlinzani

  272
  Citations

• The cleavage activities of aphthovirus and cardiovirus 2A proteins.

  Michelle L. L. Donnelly;David Gani;Mike Flint;Susan Monaghan

  262
  Citations

• Co-translational, intraribosomal cleavage of polypeptides by the foot-and-mouth disease virus 2A peptide.

  Pablo de Felipe;Lorraine E. Hughes;Martin D. Ryan;Jeremy D. Brown

  231
  Citations

• Site-specific release of nascent chains from ribosomes at a sense codon

  Victoria A. Doronina;Cheng Wu;Pablo de Felipe;Matthew S. Sachs

  220
  Citations

• Effects of Foot-and-Mouth Disease Virus Nonstructural Proteins on the Structure and Function of the Early Secretory Pathway: 2BC but Not 3A Blocks Endoplasmic Reticulum-to-Golgi Transport

  Katy Moffat;Gareth Howell;Caroline Knox;Graham J. Belsham

  194
  Citations

• Self-processing 2A-polyproteins--a system for co-ordinate expression of multiple proteins in transgenic plants.

  Claire Halpin;Susan E. Cooke;Abdellah Barakate;Abdel El Amrani

  183
  Citations

• Occurrence, function and evolutionary origins of ‘2A-like’ sequences in virus genomes

  Garry A. Luke;Pablo de Felipe;Alexander Lukashev;Susanna E. Kallioinen

  182
  Citations

• A case for "StopGo": reprogramming translation to augment codon meaning of GGN by promoting unconventional termination (Stop) after addition of glycine and then allowing continued translation (Go).

  John F. Atkins;Norma M. Wills;Gary Loughran;Chih Yu Wu

  175
  Citations

• RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies

  Fiona Tulloch;Nicky J Atkinson;David J Evans;Martin D Ryan

  167
  Citations

• Specificity of enzyme-substrate interactions in foot-and-mouth disease virus polyprotein processing

  Martin D. Ryan;Graham J. Belsham;Andrew M.Q. King

  166
  Citations

• 2A peptides provide distinct solutions to driving stop-carry on translational recoding

  Pamila Sharma;Fu Yan;Victoria A. Doronina;Helena Escuin-Ordinas

  160
  Citations

• Inhibition of the Secretory Pathway by Foot-and-Mouth Disease Virus 2BC Protein Is Reproduced by Coexpression of 2B with 2C, and the Site of Inhibition Is Determined by the Subcellular Location of 2C

  Katy Moffat;Caroline Knox;Gareth Howell;Sarah J. Clark

  141
  Citations

• Targeting of proteins derived from self-processing polyproteins containing multiple signal sequences.

  Pablo de Felipe;Martin D. Ryan

  139
  Citations

• Site-Specific Release of Nascent Chains from Ribosomes at

  Victoria A. Doronina;Cheng Wu;Pablo de Felipe;Matthew S. Sachs

  0
  Citations