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D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
13689
World Ranking
13684
National Ranking
1069

Overview

Mark A. Holmes is affiliated with the University of Cambridge in the United Kingdom and specializes in research at the intersection of biochemistry, genetics, molecular biology, and medicine. Their work spans several subfields including infectious diseases, molecular biology, molecular medicine, microbiology, and ecology.

The primary focus of their research lies in the study of antimicrobial resistance, particularly in Staphylococcus species. This includes extensive investigations into antibiotic resistance mechanisms in bacteria, bacterial biofilms and quorum sensing, and microbial infections and disease research. Additional topics covered in their work are pharmaceutical and antibiotic environmental impacts, bacteriophages and microbial interactions, and bacterial identification and susceptibility testing.

Holmes has contributed frequently to several publication venues, with notable numbers of publications in bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, Nature Communications, Microbial Genomics, and Frontiers in Microbiology.

The scientist has collaborated consistently with a group of frequent co-authors, including Xiaoliang Ba, Claire Raisen, Marta Matuszewska, G. K. Sivaraman, and Bibek Ranjan Shome.

Among their recent papers are the following:

  • Emergence of methicillin resistance predates the clinical use of antibiotics, 2022, Nature
  • The Evolutionary Genomics of Host Specificity in Staphylococcus aureus, 2020, Trends in Microbiology
  • Association between particulate matter (PM)2·5 air pollution and clinical antibiotic resistance: a global analysis, 2023, The Lancet Planetary Health
  • Genomic analysis of European bovine Staphylococcus aureus from clinical versus subclinical mastitis, 2020, Scientific Reports
  • Molecular assessment of antimicrobial resistance and virulence in multi drug resistant ESBL-producing Escherichia coli and Klebsiella pneumoniae from food fishes, Assam, India, 2020, Microbial Pathogenesis

Best Publications

  • Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440

    K. E. Nelson;C. Weinel;I. T. Paulsen;R. J. Dodson

  • Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study.

    Laura García-Álvarez;Matthew T G Holden;Heather Lindsay;Cerian R Webb

  • The emergence of mecC methicillin-resistant Staphylococcus aureus.

    Gavin K. Paterson;Ewan M. Harrison;Mark A. Holmes

  • Rapid detection, differentiation and typing of methicillin-resistant Staphylococcus aureus harbouring either mecA or the new mecA homologue mecALGA251

    M. Stegger;P.S. Andersen;A. Kearns;B. Pichon

  • Confidential enquiry of perioperative equine fatalities (CEPEF-1): preliminary results.

    G. M. Johnston;Polly M. Taylor;M. A. Holmes;J. L. N. Wood

  • Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation

    S Hodge;G Hodge;M Holmes;P N Reynolds

  • Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC.

    Ewan M. Harrison;Gavin K. Paterson;Matthew Thomas Geoffrey Holden;Jesper Larsen

  • Gene exchange drives the ecological success of a multi-host bacterial pathogen

    Emily J. Richardson;Emily J. Richardson;Rodrigo Bacigalupe;Ewan M. Harrison;Lucy A. Weinert

  • Development of a facial expression scale using footrot and mastitis as models of pain in sheep

    Krista M. McLennan;Carlos J.B. Rebelo;Murray J. Corke;Mark A. Holmes

  • Azithromycin increases phagocytosis of apoptotic bronchial epithelial cells by alveolar macrophages

    S Hodge;G Hodge;S Brozyna;H Jersmann

  • Methicillin Resistant S. aureus in Human and Bovine Mastitis

    Mark A. Holmes;Ruth N. Zadoks

  • The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolates from a diverse range of host species

    Gavin K Paterson;AR Larsen;A Robb;GE Edwards

  • Handbook of Evidence - Based Veterinary Medicine

    Peter D. Cockcroft;Mark A. Holmes

  • Immunoglobulin isotypes in sera and nasal mucosal secretions and their neonatal transfer and distribution in horses.

    Abhineet S. Sheoran;John F. Timoney;Mark A. Holmes;Stacey S. Karzenski

  • Properties of a Novel PBP2A Protein Homolog from Staphylococcus aureus Strain LGA251 and Its Contribution to the β-Lactam-resistant Phenotype

    Choonkeun Kim;Catarina Milheiriço;Susana Gardete;Susana Gardete;Mark A. Holmes

  • One Health Genomic Surveillance of Escherichia coli Demonstrates Distinct Lineages and Mobile Genetic Elements in Isolates from Humans versus Livestock.

    Catherine Ludden;Catherine Ludden;Kathy E. Raven;Dorota Jamrozy;Theodore Gouliouris;Theodore Gouliouris;Theodore Gouliouris

  • Report of the Second Equine Leucocyte Antigen Workshop, Squaw valley, California, July 1995.

    D.P Lunn;M.A Holmes;D.F Antczak;N Agerwal

  • A Shared Population of Epidemic Methicillin-Resistant Staphylococcus aureus 15 Circulates in Humans and Companion Animals

    Ewan M. Harrison;Lucy A. Weinert;Matthew T. G. Holden;John J. Welch

  • Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain.

    C. Rusbridge;H. Carruthers;M.-P. Dubé;M. Holmes

  • Evaluation of the Evidence

    Mark A. Holmes

Frequent Co-Authors

Sharon J. Peacock
Sharon J. Peacock University of Cambridge
Julian Parkhill
Julian Parkhill University of Cambridge
Gavin K. Paterson
Gavin K. Paterson University of Edinburgh
Ruth N. Zadoks
Ruth N. Zadoks University of Sydney
Anders Rhod Larsen
Anders Rhod Larsen Statens Serum Institut
Paul N. Reynolds
Paul N. Reynolds University of Adelaide
Robert Skov
Robert Skov Statens Serum Institut
Matthew T. G. Holden
Matthew T. G. Holden University of St Andrews
Sandra Hodge
Sandra Hodge University of Adelaide
M. Estée Török
M. Estée Török Bill & Melinda Gates Foundation

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