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Chemistry

D-Index
59
Citations
9623
World Ranking
10402
National Ranking
204

Overview

Maarten Merkx is affiliated with Eindhoven University of Technology in the Netherlands. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a particular emphasis on Molecular Biology, Biomedical Engineering, Radiology, Nuclear Medicine and Imaging, Immunology, and Cell Biology.

Their work covers key topics such as advanced biosensing and bioanalysis techniques, monoclonal and polyclonal antibodies research, biosensors and analytical detection, as well as bioluminescence and chemiluminescence research. Other notable research interests include biotin and related studies and CAR-T cell therapy research.

Merkx has contributed to multiple papers, with recent publications including:

  • Engineering cytokine therapeutics, 2023, Nature Reviews Bioengineering
  • A plug-and-play platform of ratiometric bioluminescent sensors for homogeneous immunoassays, 2021, Nature Communications
  • Bottom-up de novo design of functional proteins with complex structural features, 2021, Nature Chemical Biology
  • Thread-Based Bioluminescent Sensor for Detecting Multiple Antibodies in a Single Drop of Whole Blood, 2020, ACS Sensors
  • Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells, 2023, Nature Biomedical Engineering

The scientist frequently publishes in journals such as ACS Sensors, bioRxiv (Cold Spring Harbor Laboratory), Bioconjugate Chemistry, ACS Chemical Biology, and Analytical Chemistry.

Coauthorship is a significant part of Merkx's research activity. Frequent collaborators include Eva A. van Aalen, Tom F. A. de Greef, Anne de Dreu, Bas J. H. M. Rosier, and Alexander Gräwe, indicating collaborative efforts on multiple projects and studies.

Best Publications

  • Dioxygen Activation and Methane Hydroxylation by Soluble Methane Monooxygenase: A Tale of Two Irons and Three Proteins

    Maarten Merkx;Daniel A. Kopp;Matthew H. Sazinsky;Jessica L. Blazyk

  • Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

    Jing Wang;Cheng Luo;Changliang Shan;Qiancheng You;Qiancheng You

  • Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake.

    Peter V. E. van den Berghe;Dineke E. Folmer;Helga E. M. Malingré;Ellen van Beurden

  • Quantitative understanding of the energy transfer between fluorescent proteins connected via flexible peptide linkers.

    Toon H. Evers;Elisabeth M. W. M. van Dongen;Alex C. Faesen;E. W. Meijer

  • Tuning the Flexibility of Glycine-Serine Linkers To Allow Rational Design of Multidomain Proteins.

    M Martijn van Rosmalen;Mike Krom;M Maarten Merkx

  • Fluorescently labeled collagen binding proteins allow specific visualization of collagen in tissues and live cell culture

    K Katy Nash Krahn;Cvc Carlijn Bouten;S Sjoerd van Tuijl;M Marc van Zandvoort

  • Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation.

    Sidhartha M. Chafekar;Hinke Malda;Maarten Merkx;E. W. Meijer

  • Paper-Based Antibody Detection Devices Using Bioluminescent BRET-Switching Sensor Proteins

    Keisuke Tenda;Benice van Gerven;Remco Arts;Yuki Hiruta

  • An Optical Sensor Based on a Photonic Polymer Film to Detect Calcium in Serum

    M Monali Moirangthem;R Remco Arts;M Maarten Merkx;Aphj Albert Schenning

  • Detection of Antibodies in Blood Plasma Using Bioluminescent Sensor Proteins and a Smartphone.

    Remco Arts;Ilona den Hartog;Stefan E. Zijlema;Vito Thijssen

  • Mitochondrial and ER-targeted eCALWY probes reveal high levels of free Zn2+

    Pauline Chabosseau;Erkan Tuncay;Gargi Meur;Elisa A. Bellomo

  • Variation of linker length in ratiometric fluorescent sensor proteins allows rational tuning of Zn(II) affinity in the picomolar to femtomolar range

    van E.M.W.M. Dongen;T.H. Evers;L.M. Dekkers;E.W. Meijer

  • Supramolecular control of enzyme activity through cucurbit[8]uril mediated dimerization

    Dung Td Dang;HD Hoang Nguyen;HD Hoang Nguyen;M Maarten Merkx;L Luc Brunsveld

  • Multivalent Peptide and Protein Dendrimers Using Native Chemical Ligation

    Ingrid van Baal;Hinke Malda;Silvia A. Synowsky;Joost L. J. van Dongen

  • Ratiometric fluorescent sensor proteins with subnanomolar affinity for Zn(II) based on copper chaperone domains.

    Elisabeth M. W. M. van Dongen;Linda M. Dekkers;Kristie Spijker;E. W. Meijer

  • High-Affinity Peptide-Based Collagen Targeting Using Synthetic Phage Mimics: From Phage Display to Dendrimer Display

    Brett A. Helms;Sanne W. A. Reulen;Sebastiaan Nijhuis;Peggy T. H. M. de Graaf-Heuvelmans

  • High resolution imaging of collagen organisation and synthesis using a versatile collagen specific probe.

    Ralf A. Boerboom;Katy Nash Krahn;Remco T.A. Megens;Marc A.M.J. van Zandvoort

  • Electrochemical reduction of NO by hemin adsorbed at pyrolitic graphite

    Matheus T. de Groot;Maarten Merkx;and Ad H. Wonders;Marc T. M. Koper

  • Genetically-encoded FRET-based sensors for monitoring Zn2+ in living cells

    AM Anne Hessels;M Maarten Merkx

  • Why OrfY? Characterization of MMOD, a long overlooked component of the soluble methane monooxygenase from Methylococcus capsulatus (Bath).

    Maarten Merkx;Stephen J. Lippard

  • Enhanced Sensitivity of FRET‐Based Protease Sensors by Redesign of the GFP Dimerization Interface

    Jan L. Vinkenborg;Toon H. Evers;Sanne W. A. Reulen;E. W. Meijer

Frequent Co-Authors

E. W. Meijer
E. W. Meijer Eindhoven University of Technology
Michael J. Sailor
Michael J. Sailor University of California, San Diego
Shana O. Kelley
Shana O. Kelley Northwestern University
J. Justin Gooding
J. Justin Gooding University of New South Wales
Eric Bakker
Eric Bakker University of Geneva
Luc Brunsveld
Luc Brunsveld Eindhoven University of Technology
Brett A. Helms
Brett A. Helms Lawrence Berkeley National Laboratory
Nongjian Tao
Nongjian Tao Arizona State University
Marc T. M. Koper
Marc T. M. Koper Leiden University

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