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Genetics

D-Index
53
Citations
11053
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3727
National Ranking
38

Overview

Lene Christiansen is affiliated with the University of Southern Denmark in Denmark. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broad areas, their work often focuses on Molecular Biology, Genetics, and Oncology, with additional attention to Health, Toxicology and Mutagenesis, as well as Sociology and Political Science.

Their research topics include:

  • Epigenetics and DNA Methylation
  • Genetic Associations and Epidemiology
  • Health, Environment, Cognitive Aging
  • Cancer-related molecular mechanisms research
  • RNA modifications and cancer
  • Bioinformatics and Genomic Networks
  • Genetic Syndromes and Imprinting

Lene Christiansen has contributed to several scientific papers published in a variety of journals. Noteworthy recent works include:

  • "A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation" (2020, Aging Cell)
  • "Differential Long Noncoding RNA Profiling of BMI in Twins" (2020, Epigenomics)
  • "Data Resource Profile: The Copenhagen Hospital Biobank (CHB)" (2020, International Journal of Epidemiology)
  • "Novel DNA methylation marker discovery by assumption-free genome-wide association analysis of cognitive function in twins" (2021, Aging Cell)
  • "Exome-Wide Association Study Identifies FN3KRP and PGP as New Candidate Longevity Genes" (2021, The Journals of Gerontology Series A)

The frequent publication venues for Christiansen's work include:

  • Aging Cell
  • Epigenomics
  • International Journal of Epidemiology
  • The Journals of Gerontology Series A
  • Human Molecular Genetics

The scientist has collaborated with multiple researchers over time. Among the most frequent co-authors are:

  • Kaare Christensen
  • Qihua Tan
  • Marianne Nygaard
  • Jonas Mengel-From
  • Jacob Hjelmborg

Lene Christiansen's research spans a multidisciplinary approach linking genetic, epigenetic, and environmental factors to complex traits such as aging, cognitive function, and longevity. This work contributes to understanding underlying biological mechanisms in health and disease contexts through twin studies, molecular marker discovery, and genomic investigations.

Best Publications

  • Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

    Jeanne E Savage;Philip R Jansen;Philip R Jansen;Sven Stringer;Kyoko Watanabe

  • A meta-analysis of genome-wide association studies identifies multiple longevity genes

    Joris Deelen;Joris Deelen;Daniel S. Evans;Dan E. Arking;Niccolò Tesi;Niccolò Tesi

  • Epigenetic variation during the adult lifespan: cross‐sectional and longitudinal data on monozygotic twin pairs

    Rudolf P Talens;Kaare Christensen;Kaare Christensen;Hein Putter;Gonneke Willemsen

  • Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

    Jonas Mengel-From;Jonas Mengel-From;Mikael Thinggaard;Christine Dalgård;Kirsten Ohm Kyvik

  • Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.

    Joris Deelen;Marian Beekman;Hae-Won Uh;Quinta Helmer

  • Telomere Length and Mortality: A Study of Leukocytes in Elderly Danish Twins

    Masayuki Kimura;Jacob v. B. Hjelmborg;Jeffrey P. Gardner;Lise Bathum

  • Age- and sex-differences in the validity of questionnaire-based zygosity in twins.

    Lene Christiansen;Henrik Frederiksen;Karoline Schousboe;Axel Skytthe

  • DNA methylation age is associated with mortality in a longitudinal Danish twin study.

    Lene Christiansen;Adam Lenart;Qihua Tan;Qihua Tan;James W. Vaupel;James W. Vaupel

  • Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

    Joris Deelen;Marian Beekman;Hae-Won Uh;Linda Broer

  • Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans

    Massimo Mangino;Shih Jen Hwang;Timothy D. Spector;Steven C. Hunt

  • Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

    Marian Beekman;Hélène Blanché;Markus Perola;Anti Hervonen

  • Replication of an association of variation in the FOXO3A gene with human longevity using both case–control and longitudinal data

    Mette Soerensen;Serena Dato;Serena Dato;Serena Dato;Kaare Christensen;Matt McGue;Matt McGue

  • FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

    Qibin Qi;Tuomas O. Kilpeläinen;Mary K. Downer;Toshiko Tanaka

  • Novel loci and pathways significantly associated with longevity

    Yi Zeng;Yi Zeng;Chao Nie;Junxia Min;Xiaomin Liu

  • Effect of Smoking on Blood Pressure and Resting Heart Rate: A Mendelian Randomization Meta-Analysis in the CARTA Consortium

    Allan Linneberg;Rikke K Jacobsen;Tea Skaaby;Amy E Taylor

  • A Meta-analysis of Four Genome-Wide Association Studies of Survival to Age 90 Years or Older: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

    Anne B. Newman;Stefan Walter;Kathryn L. Lunetta;Kathryn L. Lunetta;Melissa E. Garcia

  • Possible gene dosage effect of glutathione-S-transferases on atopic asthma: Using real-time PCR for quantification of GSTM1 and GSTT1 gene copy numbers†

    Charlotte Brasch‐Andersen;Lene Christiansen;Qihua Tan;Annette Haagerup

  • Effect of interleukin-6 polymorphisms on human longevity: A systematic review and meta-analysis

    Danilo Di Bona;Sonya Vasto;Cristiano Capurso;Lene Christiansen

  • APOE Alleles and Extreme Human Longevity

    Paola Sebastiani;Anastasia Gurinovich;Marianne Nygaard;Takashi Sasaki

  • Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross‐sectional and longitudinal analysis

    Mette Soerensen;Mikael Thinggaard;Marianne Nygaard;Marianne Nygaard;Serena Dato;Serena Dato;Serena Dato

Frequent Co-Authors

Kaare Christensen
Kaare Christensen University of Southern Denmark
Matt McGue
Matt McGue University of Minnesota
James W. Vaupel
James W. Vaupel University of Southern Denmark
Kirsten Ohm Kyvik
Kirsten Ohm Kyvik University of Southern Denmark
Almut Nebel
Almut Nebel Kiel University
Thorkild I. A. Sørensen
Thorkild I. A. Sørensen University of Copenhagen
Vilhelm A. Bohr
Vilhelm A. Bohr University of Copenhagen
Stefan Schreiber
Stefan Schreiber Kiel University
Jan Baumbach
Jan Baumbach Universität Hamburg
Anders D. Børglum
Anders D. Børglum Aarhus University

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