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Genetics

D-Index
48
Citations
10183
World Ranking
4052
National Ranking
147

Overview

Klaas Kok is affiliated with the University of Groningen in the Netherlands. Their research spans key fields in Medicine and Biochemistry, Genetics and Molecular Biology, focusing notably on Cancer Research, Pulmonary and Respiratory Medicine, Oncology, Molecular Biology, and Pathology and Forensic Medicine.

Their recent scientific publications include:

  • Cellular senescence impairs the reversibility of pulmonary arterial hypertension, 2020, Science Translational Medicine
  • Establishment and characterisation of testicular cancer patient-derived xenograft models for preclinical evaluation of novel therapeutic strategies, 2020, Scientific Reports
  • Combined osimertinib, dabrafenib and trametinib treatment for advanced non-small-cell lung cancer patients with an osimertinib-induced BRAF V600E mutation, 2020, Lung Cancer
  • Extracellular Vesicles Enriched in hsa-miR-301a-3p and hsa-miR-1293 Dynamics in Clear Cell Renal Cell Carcinoma Patients: Potential Biomarkers of Metastatic Disease, 2020, Cancers
  • An mRNA expression-based signature for oncogene-induced replication-stress, 2022, Oncogene

Frequent co-authors contributing to Klaas Kok's collaborative works include:

  • Anke van den Berg
  • Harry J.M. Groen
  • T. Jeroen N. Hiltermann
  • Anthonie J. van der Wekken
  • Miente Martijn Terpstra

The scientist's publications have appeared predominantly in the following venues:

  • Cancers
  • Scientific Reports
  • Frontiers in Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Ovarian Research

Klaas Kok's research addresses multiple topics within their fields, including:

  • Lung Cancer Treatments and Mutations
  • Cancer Genomics and Diagnostics
  • Lung Cancer Research Studies
  • MicroRNA in disease regulation
  • Lymphoma Diagnosis and Treatment
  • Colorectal Cancer Treatments and Studies
  • Synthesis and biological activity

The body of work contributed by Klaas Kok includes 54 publications in Medicine and 36 in Biochemistry, Genetics and Molecular Biology. Of these, 20 relate to Cancer Research, 18 each to Pulmonary and Respiratory Medicine and Oncology, 16 to Molecular Biology, and 7 to Pathology and Forensic Medicine.

Best Publications

  • Consensus Statement : Chromosomal Microarray Is a First-Tier Clinical Diagnostic Test for Individuals with Developmental Disabilities or Congenital Anomalies

    David T. Miller;Margaret P. Adam;Margaret P. Adam;Swaroop Aradhya;Leslie G. Biesecker

  • Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer

    Klaas Kok;Jan Osinga;Ben Carritt;Mary B. Davis

  • Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes

    Klaas Kok;Susan L. Naylor;Charles H.C.M. Buys

  • Histone methyltransferase gene SETD2 is a novel tumor suppressor gene in clear cell renal cell carcinoma.

    Gerben Duns;Eva van den Berg;Inge van Duivenbode;Jan Osinga

  • p53 Mutations in Human Lung Tumors

    C. W. Miller;K. Simon;A. Aslo;K. Kok

  • Gene amplification as double minutes or homogeneously staining regions in solid tumors: Origin and structure

    Clelia Tiziana Storlazzi;Angelo Lonoce;Maria C. Guastadisegni;Domenico Trombetta

  • Nine patients with a microdeletion 15q11.2 between breakpoints 1 and 2 of the Prader-Willi critical region, possibly associated with behavioural disturbances.

    Marianne Doornbos;Birgit Sikkema-Raddatz;Claudia A. L. Ruijvenkamp;Trijnie Dijkhuizen

  • Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer.

    Rui-Hua Xiang;Charles H. Hensel;Dawn K. Garcia;Helene C. Carlson

  • SETD2: an epigenetic modifier with tumor suppressor functionality

    Jun Li;Gerben Duns;Helga Westers;Rolf Sijmons

  • Genotype-phenotype correlation in 21 patients with Wolf-Hirschhorn syndrome using high resolution array comparative genome hybridisation (CGH)

    N. M. C. Maas;G. Van Buggenhout;F. Hannes;B. Thienpont

  • A high throughput experimental approach to identify miRNA targets in human cells

    Lu Ping Tan;Erwin Seinen;Gerben Duns;Debora de Jong

  • A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME

    Klaas Kok;Robert Hofstra;A Pilz;van den Anke Berg

  • Resistance mechanisms after tyrosine kinase inhibitors afatinib and crizotinib in non-small cell lung cancer, a review of the literature

    A.J. van der ->Wekken;A. Saber;T.J.N. Hiltermann;K. Kok

  • A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in yeast artificial chromosomes

    K Kok;Anke van den Berg;Pmjf Veldhuis;Ay Vanderveen

  • Genomic organization and evolution of double minutes/homogeneously staining regions with MYC amplification in human cancer

    Alberto L'Abbate;Gemma Macchia;Pietro D'Addabbo;Angelo Lonoce

  • Practical guidelines for interpreting copy number gains detected by high-resolution array in routine diagnostics.

    Nicolien M Hanemaaijer;Birgit Sikkema-Raddatz;Gerben van der Vries;Trijnie Dijkhuizen

  • Cellular senescence impairs the reversibility of pulmonary arterial hypertension.

    Diederik E. van der Feen;Guido P.L. Bossers;Quint A.J. Hagdorn;Jan Renier Moonen

  • Genome-Wide Arrays: Quality Criteria and Platforms to be Used in Routine Diagnostics

    Joris R. Vermeesch;Paul D. Brady;Damien Sanlaville;Damien Sanlaville;Klaas Kok

  • Establishment and characterisation of testicular cancer patient-derived xenograft models for preclinical evaluation of novel therapeutic strategies.

    Gerda de Vries;Ximena Rosas-Plaza;Gert Jan Meersma;Vincent C. Leeuwenburgh

  • Amplicon mapping and expression profiling identify the fas-associated death domain gene as a new driver in the 11q13.3 amplicon in Laryngeal/Pharyngeal cancer

    Johan H. Gibcus;Lorian Menkema;Mirjam F. Mastik;Mario A. Hermsen

Frequent Co-Authors

Anke van den Berg
Anke van den Berg University Medical Center Groningen
Charles H.C.M. Buys
Charles H.C.M. Buys University of Groningen
Harry J.M. Groen
Harry J.M. Groen University Medical Center Groningen
Wim Timens
Wim Timens University Medical Center Groningen
Ed Schuuring
Ed Schuuring University Medical Center Groningen
Rolf H. Sijmons
Rolf H. Sijmons University of Groningen
Robert M.W. Hofstra
Robert M.W. Hofstra Erasmus University Rotterdam
Sibrand Poppema
Sibrand Poppema Sunway University
Philip M. Kluin
Philip M. Kluin University Medical Center Groningen
Ilja M. Nolte
Ilja M. Nolte University Medical Center Groningen

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