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Biology and Biochemistry

D-Index
44
Citations
9059
World Ranking
19239
National Ranking
7862

Overview

Joseph D. Smith is affiliated with the University of Washington in the United States and works primarily within the fields of Medicine and Immunology and Microbiology. Their research emphasizes Public Health, Environmental and Occupational Health, with additional focus areas that include Molecular Biology, Parasitology, Neurology, and Immunology.

The scientist's research addresses key topics such as Malaria Research and Control, Mosquito-borne diseases and control, Parasites and Host Interactions, Barrier Structure and Function Studies, the Complement system in diseases, S100 Proteins and Annexins, as well as Erythrocyte Function and Pathophysiology.

Joseph D. Smith has contributed to several notable papers, including:

  • Biophysical and biomolecular interactions of malaria-infected erythrocytes in engineered human capillaries, 2020, Science Advances
  • Determinants of brain swelling in pediatric and adult cerebral malaria, 2021, JCI Insight
  • Probing cerebral malaria inflammation in 3D human brain microvessels, 2023, Cell Reports
  • Bioengineered 3D Microvessels for Investigating Plasmodium falciparum Pathogenesis, 2021, Trends in Parasitology
  • Exploiting polypharmacology to dissect host kinases and kinase inhibitors that modulate endothelial barrier integrity, 2021, Cell chemical biology

Their frequent co-authors include:

  • Ying Zheng
  • Caitlin Howard
  • Selasi Dankwa
  • Karl B. Seydel
  • Fatou Joof

Smith often publishes in venues such as The Journal of Infectious Diseases, Science Advances, JCI Insight, Cell Reports, and Trends in Parasitology.

Best Publications

  • Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes.

    Joseph D. Smith;Chetan E. Chitnis;Alistar G. Craig;David J. Roberts

  • Severe malaria is associated with parasite binding to endothelial protein C receptor

    Louise Turner;Thomas Lavstsen;Sanne S. Berger;Christian W. Wang

  • A family affair: var genes, PfEMP1 binding, and malaria disease

    Susan M Kraemer;Joseph D Smith;Joseph D Smith

  • Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene family

    Susan M. Kraemer;Joseph D. Smith;Joseph D. Smith

  • Plasmodium falciparum domain mediating adhesion to chondroitin sulfate A: A receptor for human placental infection

    Pierre A. Buffet;Benoit Gamain;Christine Scheidig;Dror Baruch

  • Identification of a Plasmodium falciparum intercellular adhesion molecule-1 binding domain: A parasite adhesion trait implicated in cerebral malaria

    Joseph D. Smith;Alister G. Craig;Neline Kriek;Diana Hudson-Taylor

  • Malaria's deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes.

    Joseph D. Smith;Joseph D. Smith;J. Alexandra Rowe;Matthew K. Higgins;Thomas Lavstsen;Thomas Lavstsen

  • Antigenic variation in Plasmodium falciparum: gene organization and regulation of the var multigene family.

    Sue A. Kyes;Susan M. Kraemer;Joseph D. Smith;Joseph D. Smith

  • Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria.

    Adama R. Trimnell;Susan M. Kraemer;Sandeep Mukherjee;David J. Phippard

  • Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates

    Susan M Kraemer;Sue A Kyes;Gautam Aggarwal;Amy L Springer

  • A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells.

    Marion Avril;Abhai K. Tripathi;Andrew J. Brazier;Cheryl Andisi

  • Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach

    Samuel C. Wassmer;Terrie E. Taylor;Pradipsinh K. Rathod;Saroj K. Mishra

  • Identification of Multiple Chondroitin Sulfate A (CSA)–Binding Domains in the var2CSA Gene Transcribed in CSA-Binding Parasites

    Benoit Gamain;Adama R. Trimnell;Christine Scheidig;Artur Scherf

  • Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family.

    Joel H. Janes;Christopher P. Wang;Emily Levin-Edens;Inès Vigan-Womas

  • Structural polymorphism and diversifying selection on the pregnancy malaria vaccine candidate VAR2CSA.

    Joseph Bockhorst;Fangli Lu;Joel H. Janes;Jon Keebler

  • Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria

    Anne Kessler;Selasi Dankwa;Maria Bernabeu;Visopo Harawa;Visopo Harawa

  • Mapping a common interaction site used by Plasmodium falciparum Duffy binding-like domains to bind diverse host receptors.

    Dasein P.-G. Howell;Dasein P.-G. Howell;Emily A. Levin;Amy L. Springer;Susan M. Kraemer

  • Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass.

    Maria Bernabeu;Samuel A. Danziger;Marion Avril;Marina Vaz

  • The role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis research

    Joseph D. Smith

  • Advances and challenges in malaria vaccine development.

    Ruobing Wang;Joseph D. Smith;Stefan H.I. Kappe

Frequent Co-Authors

Louis H. Miller
Louis H. Miller National Institute of Allergy and Infectious Diseases
James G. Beeson
James G. Beeson Burnet Institute
Artur Scherf
Artur Scherf Institut Pasteur
Michal Fried
Michal Fried National Institutes of Health
Thomas Lavstsen
Thomas Lavstsen University of Copenhagen
Stephen J. Rogerson
Stephen J. Rogerson University of Melbourne
Patrick E. Duffy
Patrick E. Duffy National Institute of Allergy and Infectious Diseases
David L. Narum
David L. Narum National Institutes of Health
Ali Salanti
Ali Salanti Copenhagen University Hospital
Peter J. Myler
Peter J. Myler Seattle Children's Hospital

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