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José M. P. Freije

José M. P. Freije

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
17009
World Ranking
12334
National Ranking
246

Overview

José M. P. Freije is affiliated with the University of Oviedo in Spain, contributing to research primarily within biochemistry, genetics, and molecular biology. Their work also spans the field of medicine, with a significant focus on molecular biology and related subfields such as infectious diseases, cancer research, and cell biology.

Their research encompasses diverse topics including histone deacetylase inhibitors research, ubiquitin and proteasome pathways, genetics, aging, and longevity in model organisms, as well as aging and gerontology research. Additionally, they have explored areas related to SARS-CoV-2 and COVID-19, and have conducted studies on energy harvesting in wireless networks and advanced MIMO systems optimization.

José M. P. Freije has published in a variety of scientific journals, including these notable venues:

  • Frontiers in Aging
  • The EMBO Journal
  • The Journals of Gerontology Series A
  • iScience
  • Cell Death and Disease

Some recent publications illustrate the range and focus of their research:

  • "The hallmarks of aging as a conceptual framework for health and longevity research," 2024, Frontiers in Aging
  • "Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV -2 entry into human cells," 2022, The EMBO Journal
  • "Noncoding RNA Contribution to Aging and Lifespan," 2024, The Journals of Gerontology Series A
  • "Loss of ADAM29 does not affect viability and fertility in mice but improves wound healing," 2024, iScience
  • "USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy," 2023, Cell Death and Disease

Their collaborative efforts often include frequent co-authors such as:

  • Carlos López-Otín
  • Diana Campos-Iglesias
  • Alejandro P. Ugalde
  • David Roiz-Valle
  • Gabriel Bretones

Best Publications

  • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

    Xose S. Puente;Magda Pinyol;Víctor Quesada;Laura Conde

  • Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia.

    Víctor Quesada;Laura Conde;Neus Villamor;Gonzalo R Ordóñez

  • Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.

    José M.P. Freije;Irene Díez-Itza;Milagros Balbín;Luis M. Sánchez

  • Metabolic Control of Longevity

    Carlos López-Otín;Lorenzo Galluzzi;José M.P. Freije;Frank Madeo

  • Defective Prelamin A Processing and Muscular and Adipocyte Alterations in Zmpste24 Metalloproteinase-Deficient Mice

    Alberto M. Pendás;Zhongjun Zhou;Juan Cadiñanos;José M.P. Freije

  • Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation

    Ignacio Varela;Juan Cadiñanos;Alberto M. Pendás;Ana Gutiérrez-Fernández

  • Deubiquitinases in cancer: new functions and therapeutic options

    J M Fraile;V Quesada;D Rodríguez;J M P Freije

  • Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

    Ignacio Varela;Sandrine Pereira;Alejandro P Ugalde;Claire L Navarro

  • Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice.

    Clea Bárcena;Rafael Valdés-Mas;Pablo Mayoral;Cecilia Garabaya

  • Splicing-directed therapy in a new mouse model of human accelerated aging.

    Fernando G. Osorio;Claire L. Navarro;Juan Cadiñanos;Isabel C. López-Mejía

  • Chromosomal mapping and nucleotide sequence of two tandem repeats of Atlantic salmon 5S rDNA

    A M Pendas;P Moran;J P Freije;E Garcia-Vazquez

  • Identification and Characterization of Human MT5-MMP, a New Membrane-bound Activator of Progelatinase A Overexpressed in Brain Tumors

    Elena Llano;Alberto M. Pendás;José P. Freije;Atsuhisa Nakano

  • Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors

    Claire L. Navarro;Juan Cadiñanos;Annachiara De Sandre-Giovannoli;Rafaëlle Bernard

  • Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

    Fernando G. Osorio;Clea Bárcena;Clara Soria-Valles;Andrew J. Ramsay

  • Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53

    Alejandro P Ugalde;Andrew J Ramsay;Jorge de la Rosa;Ignacio Varela

  • Membrane Type 4 Matrix Metalloproteinase (MMP17) Has Tumor Necrosis Factor-α Convertase Activity but Does Not Activate Pro-MMP2 *

    William R. English;Xose S. Puente;José M.P. Freije;Vera Knäuper

  • Differential Effects of Transforming Growth Factor-β on the Expression of Collagenase-1 and Collagenase-3 in Human Fibroblasts

    José A. Urı́a;Maria G. Jiménez;Milagros Balbı́n;José M.P. Freije

  • A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential

    N. J. Macdonald;A. De La Rosa;M. A. Benedict;J. M. P. Freije

  • Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome

    Xose S. Puente;Victor Quesada;Fernando G. Osorio;Rubén Cabanillas

  • Matrix metalloproteinases and tumor progression.

    José M. P. Freije;Milagros Balbín;Alberto M. Pendás;Luis M. Sánchez

Frequent Co-Authors

Carlos López-Otín
Carlos López-Otín University of Oviedo
Alberto M. Pendás
Alberto M. Pendás University of Salamanca
Víctor Quesada
Víctor Quesada University of Oviedo
Guillermo Mariño
Guillermo Mariño University of Oviedo
Xose S. Puente
Xose S. Puente University of Oviedo
Patricia S. Steeg
Patricia S. Steeg National Institutes of Health
Eladio Viñuela
Eladio Viñuela Spanish National Research Council
Nicolas Lévy
Nicolas Lévy Aix-Marseille University
Guido Kroemer
Guido Kroemer Université Paris Cité
Mario F. Fraga
Mario F. Fraga University of Oviedo

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