World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
63
Citations
14257
World Ranking
8419
National Ranking
178

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Amino acid
  • Biochemistry

G.H. de Haas mainly focuses on Biochemistry, Phospholipase A2, Chromatography, Phospholipase A and Substrate. His Biochemistry study is mostly concerned with Phospholipase, Peptide sequence, Zymogen, Enzyme and Snake venom. In his study, which falls under the umbrella issue of Enzyme, Rhizopus arrhizus is strongly linked to Fatty acid ester.

His research in Phospholipase A2 intersects with topics in Active site, Porcine pancreas, Stereochemistry, Structure–activity relationship and Binding site. The various areas that G.H. de Haas examines in his Chromatography study include Colipase, Sephadex and Phosphatidic acid. His Phospholipase A study combines topics in areas such as Cardiolipin and Phospholipase B.

His most cited work include:

  • Purification and properties of phospholipase a from porcine pancreas (504 citations)
  • Histidine at the active site of phospholipase A2 (431 citations)
  • Structure and function of phospholiphase A2 (430 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Biochemistry, Stereochemistry, Phospholipase A2, Enzyme and Phospholipase A. His Stereochemistry research includes elements of Micelle, Non-competitive inhibition, Active site, Hydrolysis and Substrate. His study looks at the relationship between Phospholipase A2 and topics such as Lecithin, which overlap with Molecule.

His Enzyme research is multidisciplinary, relying on both Residue, Tyrosine and Alanine. He has included themes like Chromatography, Ethanolamines, Enzymatic hydrolysis and Fatty acid in his Phospholipase A study. As part of one scientific family, G.H. de Haas deals mainly with the area of Phospholipase, narrowing it down to issues related to the Binding site, and often Structure–activity relationship.

He most often published in these fields:

  • Biochemistry (44.62%)
  • Stereochemistry (33.08%)
  • Phospholipase A2 (32.31%)

What were the highlights of his more recent work (between 1993-2010)?

  • Stereochemistry (33.08%)
  • Enzyme (31.54%)
  • Organic chemistry (16.92%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Stereochemistry, Enzyme, Organic chemistry, Phospholipase A2 and Cutinase. His Stereochemistry study incorporates themes from L serine, Cardiolipin, Non-competitive inhibition and Active site. His work carried out in the field of Enzyme brings together such families of science as Residue and Micelle.

Biochemistry covers G.H. de Haas research in Phospholipase A2. The study incorporates disciplines such as Heteronuclear molecule, Nuclear magnetic resonance spectroscopy and Hydrogen bond in addition to Biochemistry. His Cutinase research integrates issues from Phosphonate and Lipase.

Between 1993 and 2010, his most popular works were:

  • Cutinase from Fusarium solani pisi hydrolyzing triglyceride analogues. Effect of acyl chain length and position in the substrate molecule on activity and enantioselectivity. (81 citations)
  • Hereditary Hemorrhagic Telangiectasia: ENG and ALK-1 Mutations in Dutch Patients (79 citations)
  • Crystal structure of cutinase covalently inhibited by a triglyceride analogue (77 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Amino acid
  • Organic chemistry

G.H. de Haas mainly investigates Stereochemistry, Enzyme, Cutinase, Lipase and Tetrahedral carbonyl addition compound. His work on Enantiomer as part of general Stereochemistry research is frequently linked to Chain length, bridging the gap between disciplines. His study in Phospholipase A2 and Ternary complex falls within the category of Enzyme.

His Cutinase research incorporates themes from Substituent and Alkyl. G.H. de Haas combines subjects such as Phosphonate, Mutant, Glycerol and Acylation with his study of Lipase. His work in Tetrahedral carbonyl addition compound incorporates the disciplines of Active site, Catalysis, X-ray crystallography, Crystal structure and Covalent bond.

Best Publications

  • Purification and properties of phospholipase a from porcine pancreas

    G.H. de Haas;N.M. Postema;W. Nieuwenhuizen;L.L.M van Deenen

  • Structure and function of phospholiphase A2

    H. M. Verheij;A. J. Slotboom;G. H. de Haas

  • Histidine at the active site of phospholipase A2

    J J Volwerk;W A Pieterson;G H de Haas

  • Action of phospholipase A at interfaces.

    Robert Verger;Maria C.E. Mieras;Gerard H. de Haas

  • THE SUBSTRATE SPECIFICITY OF PHOSPHOLIPASE A.

    L.L.M. Van Deenen;G.H. De Haas

  • Studies on phospholipase A and its zymogen from porcine pancreas: III. Action of the enzyme on short-chain lecithins

    G.H. De Haas;P.P.M. Bonsen;W.A. Pieterson;L.L.M. Van Deenen

  • Enzyme reactions in a membrane model 1: A new technique to study enzyme reactions in monolayers

    Robert Verger;Gerard H. de Haas

  • Zymogen-catalyzed hydrolysis of monomeric substrates and the presence of a recognition site for lipid-water interfaces in phospholipase A2.

    W. A. Pieterson;J. C. Vidal;J. J. Volwerk;G. H. De Haas

  • Methylation of Histidine-48 in Pancreatic Phospholipase A2: Role of Histidine and Calcium Ion in the Catalytic Mechanism

    Hubertus M. Verheij;J.J. Volwerk;E.H.J.M. Jansen;W.C. Puyk

  • The interaction of phospholipase A2 with micellar interfaces. The role of the N-terminal region.

    M. C. E. Van Dam-Mieras;A. J. Slotboom;W. A. Pieterson;G. H. De Haas

  • Purification from porcine pancreas of two molecular species with lipase activity

    R. Verger;G.H. De Haas;L. Sarda;P. Desnuelle

  • Studies on phospholipase a and its zymogen from porcine pancreas IV. The influence of chemical modification of the lecithin structure on substrate properties

    P.P.M. Bonsen;G.H. de Haas;W.A. Pieterson;L.L.M. Van Deenen

  • Purification and properties of an anionic zymogen of phospholipase a from porcine pancreas

    G.H. De Haas;N.M. Postema;W. Nieuwenhuizen;L.L.M. Van Deenen

  • Phospholipase A2 and its zymogen from porcine pancreas. V. Interaction of phospholipase A2 and its zymogen with divalent metal ions

    W. A. Pieterson;J. J. Volwerk;G. H. De Haas

  • The synthesis of phosphoglycerides and some biochemical applications.

    L.L.M. Van Deenen;G.H. De Haas

  • Positional specific hydrolysis of phospholipids by pancreatic lipase

    G.H. de Haas;L. Sarda;J. Roger

  • Origin of the latency phase during the action of phospholipase A2 on unmodified phosphatidylcholine vesicles

    Rafael Apitz-Castro;Mahendra K. Jain;Gerard H. De Haas

  • Purification and Substrate Specificity of Staphylococcus Hyicus Lipase

    van Oort Mg;Deveer Am;Dijkman R;Tjeenk Ml

  • Hydrolysis of phosphoglycerides by purified lipase preparations I. Substrate-, positional- and stereo-specificity

    A.J. Slotboom;G.H. de Haas;P.P.M. Bonsen;G.J. Burbach-Westerhuis

  • Kinetic analysis of the hydrolysis of lecithin monolayers by phospholipase A.

    G. Zografi;R. Verger;G.H. de Haas

  • Regulation of phospholipase A2 activity by the lipid-water interface: a monolayer approach.

    F. Pattus;A. J. Slotboom;G. H. De Haas

Frequent Co-Authors

L.L.M. Van Deenen
L.L.M. Van Deenen Utrecht University
Hubertus M. Verheij
Hubertus M. Verheij Utrecht University
Maarten R. Egmond
Maarten R. Egmond Utrecht University
Robert Verger
Robert Verger Centre national de la recherche scientifique, CNRS
Rolf Boelens
Rolf Boelens Utrecht University
Robert Kaptein
Robert Kaptein Utrecht University
Franc Pattus
Franc Pattus École Normale Supérieure
Oscar P. Kuipers
Oscar P. Kuipers University of Groningen
Joachim Seelig
Joachim Seelig University of Basel
Ben Roelofsen
Ben Roelofsen Utrecht University

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