World's Best Scientists 2026 revealed!
George I. Papakostas

George I. Papakostas

D-Index & Metrics

Psychology

D-Index
76
Citations
19614
World Ranking
1728
National Ranking
1018

Overview

George I. Papakostas is affiliated with Harvard University in the United States and has contributed extensively to research in the fields of Medicine and Neuroscience. Their work often intersects key subfields such as Pharmacology, Biological Psychiatry, Psychiatry and Mental Health, Experimental and Cognitive Psychology, and Cognitive Neuroscience.

The primary focus of Papakostas's research centers on the treatment of major depression, with additional interests spanning tryptophan and brain disorders, mental health research topics, electroconvulsive therapy studies, stress responses and cortisol, functional brain connectivity studies, and bipolar disorder and its treatment.

Their recent papers include:

  • Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation (2021, American Journal of Psychiatry)
  • Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode (2022, JAMA Psychiatry)
  • Efficacy of Esketamine Augmentation in Major Depressive Disorder (2020, The Journal of Clinical Psychiatry)
  • International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators (2022, Molecular Psychiatry)
  • Impact of Supplementation and Nutritional Interventions on Pathogenic Processes of Mood Disorders: A Review of the Evidence (2021, Nutrients)

Frequent co-authors of Papakostas include:

  • Maurizio Fava (25 publications)
  • Madhukar H. Trivedi (20 publications)
  • Manish K. Jha (15 publications)
  • Marlene P. Freeman (13 publications)
  • Sanjay J. Mathew (11 publications)

They have published predominantly in the following venues:

  • The Journal of Clinical Psychiatry (15 publications)
  • Molecular Psychiatry (3 publications)
  • European Neuropsychopharmacology (3 publications)
  • Journal of Affective Disorders (3 publications)
  • CNS Spectrums (3 publications)

George I. Papakostas's research contributes primarily to understanding and improving treatments for mood disorders, focusing on pharmacological approaches such as ketamine and esketamine treatment for depression. Their work includes meta-analyses and clinical studies aimed at evaluating efficacy, safety, and clinical moderators in treatment outcomes.

Best Publications

  • Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials.

    J. Craig Nelson;George I. Papakostas

  • Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation

    Roger S McIntyre;Roger S McIntyre;Joshua D Rosenblat;Joshua D Rosenblat;Charles B Nemeroff;Gerard Sanacora

  • Does the probability of receiving placebo influence clinical trial outcome? A meta-regression of double-blind, randomized clinical trials in MDD.

    George I. Papakostas;Maurizio Fava

  • Treatment-resistant depression

    Daniel Souery;George I.George Papakostas;Madhukar Trivedi

  • Quality of life assessments in major depressive disorder: a review of the literature.

    George I. Papakostas;Timothy Petersen;Yasmin Mahal;David Mischoulon

  • Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses

    Jerome Sarris;Jenifer Murphy;David Mischoulon;George I. Papakostas

  • Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)

    Maurizio Fava;Marlene P. Freeman;Martina Flynn;Heidi Judge

  • Are Antidepressant Drugs That Combine Serotonergic and Noradrenergic Mechanisms of Action More Effective Than the Selective Serotonin Reuptake Inhibitors in Treating Major Depressive Disorder? A Meta-analysis of Studies of Newer Agents

    George I. Papakostas;Michael E. Thase;Michael E. Thase;Maurizio Fava;J. Craig Nelson

  • S-Adenosyl Methionine (SAMe) Augmentation of Serotonin Reuptake Inhibitors for Antidepressant Nonresponders With Major Depressive Disorder: A Double-Blind, Randomized Clinical Trial

    George I. Papakostas;David Mischoulon;Irene Shyu;Jonathan E. Alpert

  • A Detailed Examination of Cytokine Abnormalities in Major Depressive Disorder

    N.M. Simon;K. McNamara;C.W. Chow;R.S. Maser

  • Treatment of SSRI-Resistant Depression: A Meta-Analysis Comparing Within- Versus Across-Class Switches

    George I. Papakostas;Maurizio Fava;Michael E. Thase;Michael E. Thase

  • Augmentation of antidepressants with atypical antipsychotic medications for treatment-resistant major depressive disorder: a meta-analysis.

    George I. Papakostas;Richard C. Shelton;Juliana Smith;Maurizio Fava

  • L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials.

    George I. Papakostas;Richard C. Shelton;John M. Zajecka;Bijan Etemad

  • Consensus Statement and Research Needs: The Role of Dopamine and Norepinephrine in Depression and Antidepressant Treatment

    David J. Nutt;David S. Baldwin;Anita H. Clayton;Rodney Elgie

  • Efficacy of antidepressants for late-life depression: a meta-analysis and meta-regression of placebo-controlled randomized trials.

    Enrico Tedeschini;Yeciel Levkovitz;Nadia Iovieno;Victoria E. Ameral

  • Relationship between sleep disturbance and depression, anxiety, and functioning in college students.

    Maren Nyer;Amy Farabaugh;B A Kiki Fehling;David Soskin

  • A cross-sectional study of the prevalence of cognitive and physical symptoms during long-term antidepressant treatment

    Maurizio Fava;Lesley M. Graves;Franco Benazzi;Margaret J. Scalia

  • Dopaminergic-based pharmacotherapies for depression

    George I. Papakostas

  • Tolerability of modern antidepressants.

    George I Papakostas

  • Assessment of a multi-assay, serum-based biological diagnostic test for major depressive disorder: a Pilot and Replication Study

    G I Papakostas;R C Shelton;G Kinrys;M E Henry

  • Resolution of sleepiness and fatigue in major depressive disorder: A comparison of bupropion and the selective serotonin reuptake inhibitors.

    George I. Papakostas;David J. Nutt;Lindsay A. Hallett;Vivian L. Tucker

Frequent Co-Authors

David Mischoulon
David Mischoulon Harvard University
Michael E. Thase
Michael E. Thase University of Pennsylvania
Lee Baer
Lee Baer Harvard University
Sanjay J. Mathew
Sanjay J. Mathew Baylor College of Medicine
Lawrence H. Price
Lawrence H. Price Brown University
Audrey R. Tyrka
Audrey R. Tyrka Brown University
Paola Pedrelli
Paola Pedrelli Massachusetts General Hospital
Eduard Vieta
Eduard Vieta University of Barcelona
Stuart Montgomery
Stuart Montgomery Imperial College London
Anne Klibanski
Anne Klibanski Harvard University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Psychology in the USA often opens doors to related fields such as social work and counseling. Many students discover that a psychology background forms a strong foundation for pursuing advanced roles in mental health and community support.

Depending on your career goals, requirements for becoming a social worker can vary by state. For example, if you want to practice in Oregon, it's essential to understand social worker degree requirements in Oregon, which typically involve earning a bachelor's or master's degree in social work.

Other states have unique pathways as well. In Pennsylvania, aspiring professionals should review the Pennsylvania education requirements for social workers to ensure compliance with local regulations. Similarly, research the degree needed to be a social worker in Rhode Island and the degree needed to be a social worker in South Carolina if you are considering a career in those locations.

Many reputable institutions offer flexible online psychology and social work programs that match these requirements, making it easier for you to start your ideal career path from almost anywhere.

Best Scientists Citing George I. Papakostas

Trending Scientists

Recently Published Articles