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Francine B. Perler

Francine B. Perler

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
10736
World Ranking
18609
National Ranking
7607

Overview

Francine B. Perler is affiliated with New England Biolabs in the United States and contributes to research primarily in the fields of Environmental Science and Biochemistry, Genetics and Molecular Biology. Their scientific work focuses on areas such as Ecology and Molecular Biology, with an emphasis on microbial life and interactions.

The main topics addressed in Perler's work include:

  • Bacteriophages and microbial interactions
  • Genomics and Phylogenetic Studies
  • Microbial Community Ecology and Physiology

Among their recent publications, one notable paper is titled "Going to extremes - a metagenomic journey into the dark matter of life", published in 2021 in FEMS Microbiology Letters. This paper explores metagenomics, a field that allows for the study of genetic material recovered directly from environmental samples, shedding light on previously uncharacterized microbial life. This publication has received citations, reflecting its relevance in ongoing scientific discussions.

Perler has collaborated with several researchers on their projects, indicating a network of co-authors contributing to the study of microbial ecology and related fields. Frequent co-authors include:

  • Arnthór Aevarsson
  • Anna-Karina Kaczorowska
  • Björn Þór Aðalsteinsson
  • Josefin Ahlqvist
  • Salam Al-Karadaghi

Their work has appeared in scientific venues such as:

  • FEMS Microbiology Letters

Perler's research adds to the understanding of microbial communities in extreme environments and their ecological functions. This research is relevant to advancing knowledge in microbial genomics and the interactions between bacteriophages and their hosts, informing broader studies on environmental microbiology and molecular biology.

Best Publications

  • Single-column purification of free recombinant proteins using a self-cleavable affinity tag derived from a protein splicing element.

    Shaorong Chong;Fana B. Mersha;Donald G. Comb;Melissa E. Scott

  • The evolution of genes: the chicken preproinsulin gene

    Francine Perler;Argiris Efstratiadis;Peter Lomedico;Walter Gilbert

  • InBase: the Intein Database

    Francine B. Perler

  • Protein splicing elements: inteins and exteins — a definition of terms and recommended nomenclature

    Francine B. Perler;Elaine O. Davis;Gary E. Dean;Frederick S. Gimble

  • Protein Splicing of Inteins and Hedgehog Autoproteolysis: Structure, Function, and Evolution

    Francine B Perler

  • The mechanism of protein splicing and its modulation by mutation.

    M. Q. Xu;F. B. Perler

  • Protein Splicing Involving the Saccharomyces cerevisiae VMA Intein THE STEPS IN THE SPLICING PATHWAY, SIDE REACTIONS LEADING TO PROTEIN CLEAVAGE, AND ESTABLISHMENT OF AN IN VITRO SPLICING SYSTEM

    Shaorong Chong;Yang Shao;Henry Paulus;Jack Benner

  • Dissecting the Chemistry of Protein Splicing and Its Applications.

    Christopher J. Noren;Jimin Wang;Francine B. Perler

  • Purification of proteins fused to either the amino or carboxy terminus of the Mycobacterium xenopi gyrase A intein.

    Maurice W. Southworth;Kensey Amaya;Thomas C. Evans;Ming-Qun Xu

  • Intervening sequences in an Archaea DNA polymerase gene.

    F B Perler;D G Comb;W E Jack;L S Moran

  • In vitro protein splicing of purified precursor and the identification of a branched intermediate

    Ming-Qun Xu;Maurice W. Southworth;Fana B. Mersha;Linda J. Hornstra

  • Compilation and analysis of intein sequences

    Francine B. Perler;Gary J. Olsen;Eric Adam

  • Extremozymes: Expanding the Limits of Biocatalysis

    Michael W.W. Adams;Francine B. Perler;Robert M. Kelly

  • Thermostable DNA polymerases.

    Francine B. Perler;Sanjay Kumar;Huimin Kong

  • Control of protein splicing by intein fragment reassembly

    Maurice W. Southworth;Eric Adam;Daniel Panne;Robyn Byer

  • Protein splicing and autoproteolysis mechanisms.

    Francine B Perler;Ming-Qun Xu;Henry Paulus

  • Protein splicing in cis and in trans.

    Lana Saleh;Francine B. Perler

  • Protein splicing: an analysis of the branched intermediate and its resolution by succinimide formation.

    M.Q. Xu;D.G. Comb;H. Paulus;C.J. Noren

  • Cloning of thermostable DNA polymerases from hyperthermophilic marine Archaea with emphasis on Thermococcus sp. 9 degrees N-7 and mutations affecting 3'-5' exonuclease activity

    M W Southworth;H Kong;R B Kucera;J Ware

  • Protein splicing removes intervening sequences in an archaea DNA polymerase

    Robert A. Hodges;Francine B. Perler;Christopher J. Noren;William E. Jack

Frequent Co-Authors

David Abraham
David Abraham University College London
Jimin Wang
Jimin Wang Yale University
Henry Paulus
Henry Paulus Boston Biomedical Research Institute
Kurt Wüthrich
Kurt Wüthrich ETH Zurich
Rocky S. Tuan
Rocky S. Tuan Chinese University of Hong Kong
Phillips W. Robbins
Phillips W. Robbins Boston University
John W. Barnwell
John W. Barnwell Centers for Disease Control and Prevention
Michael W. W. Adams
Michael W. W. Adams University of Georgia
Gary J. Olsen
Gary J. Olsen University of Illinois at Urbana-Champaign
Marlene Belfort
Marlene Belfort University at Albany, State University of New York

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