Edward C. Taylor

Research.com Recognitions

• 2013 - NAS Award for Chemistry in Service to Society, U.S. National Academy of Sciences For his contributions to heterocyclic chemistry, in particular the discovery of the new-generation antifolate pemetrexed, approved for the treatment of mesothelioma and non-small cell lung cancer and under clinical investigation for treatment of a variety of other solid tumors.
• 2012 - Fellow of the American Chemical Society
• 1979 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Best Publications

• A dideazatetrahydrofolate analog lacking a chiral center at C-6: N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5yl)ethyl[benzoyl]-L-glutamic acid is an inhibitor of thymidylate synthase

  Edward C. Taylor;Dietmar Kuhnt;Chuan Shih;Sharon M. Rinzel

  370
  Citations

• Photochemical reactions of azoxy compounds, nitrones, and aromatic amine N-oxides

  Gavin G. Spence;Edward Curtis. Taylor;Ole. Buchardt

  290
  Citations

• 1,5-Dipolar cyclizations

  Edward C. Taylor;Ignatius J. Turchi

  223
  Citations

• Synthesis of pyrazolo 3,4-pyrimidine analogues of the potent agent N-4-2-2-amino-4 3-oxo-7-pyrrolo 2,3-pyrimidin-5-yl ethylbenzoyl-L-glutamic acid (LY231514)

  Edward C. Taylor;Hemantkumar H. Patel

  222
  Citations

• Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.

  E C Taylor;P J Harrington;S R Fletcher;G P Beardsley

  219
  Citations

• Thallium in organic synthesis. 58. Regiospecific intermolecular oxidative dehydrodimerization of aromatic compounds to biaryls using thallium(III) trifluoroacetate

  Alexander McKillop;Andrew G. Turrell;Derek W. Young;Edward C. Taylor

  214
  Citations

• Thallium in organic synthesis

  Edward Curtis Taylor;Alexander McKillop

  165
  Citations

• Thallium in organic synthesis. XXII. Electrophilic aromatic thallation using thallium(III) trifluoroacetate. Simple synthesis of aromatic iodides

  Alexander McKillop;John D. Hunt;Michael J. Zelesko;Joanna S. Fowler

  157
  Citations

• Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase

  Samuel W. Baldwin;Archie Tse;Lynn S. Gossett;Edward C. Taylor

  149
  Citations

• PYRIDINE-1-OXIDES. I. SYNTHESIS OF SOME NICOTINIC ACID DERIVATIVES1

  E. C. Taylor;Aldo J. Crovetti

  148
  Citations

• Thallium in organic synthesis. 59. Alkaloid synthesis via intramolecular nonphenolic oxidative coupling. Preparation of (.+-.)-ocoteine, (.+-.)-acetoxyocoxylonine, (.+-.)-3-methoxy-n-acetylnornantenine, (.+-.)-neolitsine, (.+-.)-kreysigine, (.+-.)-O-methylkreysigine, and (.+-.)-multifloramine

  Edward C. Taylor;Juan G. Andrade;Gerhardus J. H. Rall;Alexander McKillop

  145
  Citations

• The 6S- and 6R-diastereomers of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolate are equiactive inhibitors of de novo purine synthesis.

  R. G. Moran;R. G. Moran;S. W. Baldwin;E. C. Taylor;Chuan Shih

  144
  Citations

• N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives

  Edward C. Taylor;Dietmar G. Kuhnt;Chuan Shih;Gerald B. Grindey

  138
  Citations

• Thallium in organic synthesis. XXXVIII. Oxidation of chalcones, deoxybenzoins, and benzoins with thallium(III) nitrate (TTN)

  Alexander. McKillop;Brian P. Swann;Michael E. Ford;Edward C. Taylor

  136
  Citations

• Purine Nucleosides. I. The Synthesis of Certain 6-Substituted-9-(tetrahydro-2-pyranyl)-purines as Models of Purine Deoxynucleosides1

  Roland K. Robins;Erik F. Godefroi;Edward C. Taylor;Leland R. Lewis

  132
  Citations

• Novel synthesis of a conformationally-constrained analog of DDATHF

  Edward C. Taylor;Ping Zhou;Lee D. Jennings;Zhenmin Mao

  130
  Citations

• A Convenient Synthesis of N,N'-Disubstituted Formamidines and Acetamidines1

  Edward C. Taylor;Wendell A. Ehrhart

  127
  Citations

• Intramolecular diels-alder reactions of 1,2,4-triazines.

  Edward C. Taylor;John E. Macor;Joseph L. Pont

  120
  Citations

• Thallium in organic synthesis. 68. A convenient synthesis of 2-phenylindoles from anilides

  Edward C. Taylor;Alan H. Katz;Hector Salgado-Zamora;Alexander McKillop

  119
  Citations

• Convergent and efficient palladium-effected synthesis of 5, 10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)

  Edward C. Taylor;George S. K. Wong

  117
  Citations