World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
45
Citations
6803
World Ranking
16520
National Ranking
915

Overview

Daniel Shiu-Hin Chan is affiliated with the University of Cambridge in the United Kingdom. Their research spans several interdisciplinary areas primarily within Biochemistry, Genetics and Molecular Biology, Chemistry, and Medicine. Their publication record includes 21 works in Biochemistry, Genetics and Molecular Biology, 17 in Chemistry, and 11 in Medicine, demonstrating a focus on both foundational biochemical processes and their chemical applications in medical science.

The scientist's notable subfields of study comprise Molecular Biology, Organic Chemistry, Biomedical Engineering, Spectroscopy, and Materials Chemistry. This diverse specialization supports their exploration of complex biological systems and the development of chemical tools for biomedical purposes.

Research topics prominently featured in their work include advanced biosensing and bioanalysis techniques, nanoplatforms for cancer theranostics, click chemistry and its applications, molecular sensors and ion detection, DNA and nucleic acid chemistry, catalytic alkyne reactions, and catalytic C-H functionalization methods. These areas underline Chan's engagement with chemical innovations aimed at improving diagnostic and therapeutic processes, particularly in oncology.

Frequently publishing in reputable venues, Chan has contributed to Chemistry - A European Journal with three papers, as well as the Journal of the American Chemical Society, European Journal of Medicinal Chemistry, Inorganic Chemistry Frontiers, and Chemical Engineering Journal. This range reflects a multidisciplinary approach bridging chemistry and biomedical engineering.

Collaborations form a significant part of their scientific output. Frequent co-authors include Wanhe Wang, Chun-Yuen Wong, Chung-Hang Leung, Sang-Cuo Nao, and Shaozhen Jing, each contributing multiple joint publications. These partnerships indicate an active engagement in collaborative research networks.

Selected recent papers authored include:

  • "A glycyrrhetinic acid-iridium(III) conjugate as a theranostic NIR probe for hepatocellular carcinoma with mitochondrial-targeting ability" (2023, European Journal of Medicinal Chemistry)
  • "Inhibiting Glycolysis and Disrupting the Mitochondrial HK2-VDAC1 Protein-Protein Interaction Using a Bifunctional Lonidamine-Conjugated Metal Probe for Combating Triple-Negative Breast Cancer" (2025, Journal of the American Chemical Society)
  • "Luminescent iridiumiii-peptide bioconjugates for bioanalytical and biomedical applications" (2024, Inorganic Chemistry Frontiers)
  • "Probing the AFF4-CCNT1 protein-protein interaction using a metal-organic conjugate for treating triple-negative breast cancer" (2024, Chemical Engineering Journal)
  • "Microfluidic detection using G-quadruplex DNA-based biosensors" (2024, TrAC Trends in Analytical Chemistry)

Best Publications

  • Bioactive Luminescent Transition‐Metal Complexes for Biomedical Applications

    Dik-Lung Ma;Hong-Zhang He;Ka-Ho Leung;Daniel Shiu-Hin Chan

  • Bioactive iridium and rhodium complexes as therapeutic agents

    Chung-Hang Leung;Hai-Jing Zhong;Daniel Shiu-Hin Chan;Dik-Lung Ma

  • Group 9 organometallic compounds for therapeutic and bioanalytical applications.

    Dik-Lung Ma;Daniel Shiu-Hin Chan;Chung-Hang Leung

  • Recent advances in luminescent heavy metal complexes for sensing

    Dik-Lung Ma;Victor Pui-Yan Ma;Daniel Shiu-Hin Chan;Ka-Ho Leung

  • Drug repositioning by structure-based virtual screening

    Dik-Lung Ma;Daniel Shiu-Hin Chan;Chung-Hang Leung

  • Label-free luminescent oligonucleotide-based probes

    Dik-Lung Ma;Hong-Zhang He;Ka-Ho Leung;Hai-Jing Zhong

  • Molecular docking for virtual screening of natural product databases

    Dik-Lung Ma;Daniel Shiu-Hin Chan;Chung-Hang Leung

  • A Metal-Based Inhibitor of Tumor Necrosis Factor-α

    Chung-Hang Leung;Hai-Jing Zhong;Hui Yang;Zhen Cheng

  • G-quadruplexes for luminescent sensing and logic gates.

    Hong-Zhang He;Daniel Shiu-Hin Chan;Chung-Hang Leung;Dik-Lung Ma

  • Structure‐Based Discovery of Natural‐Product‐like TNF‐α Inhibitors

    Daniel Shiu-Hin Chan;Ho-Man Lee;Fang Yang;Chi-Ming Che

  • Group 9 metal-based inhibitors of β-amyloid (1–40) fibrillation as potential therapeutic agents for Alzheimer's disease

    Bradley Yat-Wah Man;Ho-Man Chan;Chung-Hang Leung;Daniel Shiu-Hin Chan

  • Simple and convenient G-quadruplex-based turn-on fluorescence assay for 3' → 5' exonuclease activity.

    Chung-Hang Leung;Daniel Shiu-Hin Chan;Bradley Yat-Wah Man;Chuan-Jen Wang

  • Detection of nicking endonuclease activity using a G-quadruplex-selective luminescent switch-on probe

    Lihua Lu;Daniel Shiu-Hin Chan;Daniel W. J. Kwong;Hong-Zhang He

  • Antagonizing STAT3 Dimerization with a Rhodium(III) Complex

    Dik-Lung Ma;Li-Juan Liu;Ka-Ho Leung;Yen-Ting Chen

  • Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe

    Hong-Zhang He;Ka-Ho Leung;Wei Wang;Daniel Shiu-Hin Chan

  • Simple DNA-based logic gates responding to biomolecules and metal ions

    Dik-Lung Ma;Hong-Zhang He;Daniel Shiu-Hin Chan;Chung-Hang Leung

  • Detection of base excision repair enzyme activity using a luminescent g-quadruplex selective switch-on probe

    Ka-Ho Leung;Hong-Zhang He;Victor Pui-Yan Ma;Hai-Jing Zhong

  • A highly selective, label-free, homogenous luminescent switch-on probe for the detection of nanomolar transcription factor NF-kappaB

    Dik-Lung Ma;Ting Xu;Daniel S.-H. Chan;Bradley Y.-W. Man

  • Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening

    Ho-Man Lee;Daniel Shiu-Hin Chan;Fang Yang;Ho-Yu Lam

  • A selective G-quadruplex-based luminescent switch-on probe for the detection of nanomolar silver(I) ions in aqueous solution.

    Bradley Yat-Wah Man;Daniel Shiu-Hin Chan;Daniel Shiu-Hin Chan;Hui Yang;Si-Wo Ang

  • An oligonucleotide-based switch-on luminescent probe for the detection of kanamycin in aqueous solution

    Ka-Ho Leung;Hong-Zhang He;Daniel Shiu-Hin Chan;Wai-Chung Fu

  • A selective oligonucleotide-based luminescent switch-on probe for the detection of nanomolar mercury(II) ion in aqueous solution.

    Daniel Shiu-Hin Chan;Ho-Man Lee;Chi-Ming Che;Chung-Hang Leung

  • Oligonucleotide-based luminescent detection of metal ions.

    Dik-Lung Ma;Daniel Shiu-Hin Chan;Bradley Yat-Wah Man;Chung-Hang Leung

Frequent Co-Authors

Chung-Hang Leung
Chung-Hang Leung University of Macau
Dik-Lung Ma
Dik-Lung Ma Hong Kong Baptist University
Philip Wai Hong Chan
Philip Wai Hong Chan Monash University
Chi-Ming Che
Chi-Ming Che University of Hong Kong
Zhi-Hong Jiang
Zhi-Hong Jiang Macau University of Science and Technology
Yung-Chi Cheng
Yung-Chi Cheng Yale University
Ruben Abagyan
Ruben Abagyan University of California, San Diego
Simon Ming-Yuen Lee
Simon Ming-Yuen Lee University of Macau
Naresh Kumar
Naresh Kumar University of New South Wales

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