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Biology and Biochemistry

D-Index
60
Citations
10884
World Ranking
12123
National Ranking
316

Overview

Christi J. van Asperen is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily focuses on genetics, oncology, and cancer research within the broader fields of biochemistry, genetics, molecular biology, and medicine.

Their academic contributions include extensive work on BRCA gene mutations and cancer risk, cancer genomics and diagnostics, ovarian cancer diagnosis and treatment, genetic factors in colorectal cancer, genetic associations and epidemiology, genomics and rare diseases, and genomic variations and chromosomal abnormalities.

Frequent co-authors of Christi J. van Asperen include:

  • Margreet G.E.M. Ausems
  • E. Gómez
  • Klaartje van Engelen
  • Marian J.E. Mourits
  • Maartje J. Hooning

Primary publication venues for their work include:

  • Genetics in Medicine
  • JNCI Journal of the National Cancer Institute
  • Journal of Medical Genetics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • European Journal of Human Genetics

Notable recent papers authored or co-authored by Christi J. van Asperen are:

  • Endometrial Cancer Risk in Women With Germline BRCA1 or BRCA2 Mutations: Multicenter Cohort Study, 2021, JNCI Journal of the National Cancer Institute
  • Breast cancer risks associated with missense variants in breast cancer susceptibility genes, 2022, Genome Medicine
  • Recommendations for reporting results of diagnostic genomic testing, 2022, European Journal of Human Genetics
  • Clinical applicability of the Polygenic Risk Score for breast cancer risk prediction in familial cases, 2022, Journal of Medical Genetics
  • Alternative mRNA splicing can attenuate the pathogenicity of presumed loss-of-function variants in BRCA2, 2020, Genetics in Medicine

Best Publications

  • Association analysis identifies 65 new breast cancer risk loci

    Kyriaki Michailidou;Kyriaki Michailidou;Sara Lindström;Sara Lindström;Joe Dennis;Jonathan Beesley

  • Large-scale genotyping identifies 41 new loci associated with breast cancer risk

    Kyriaki Michailidou;Per Hall;Anna Gonzalez-Neira;Maya Ghoussaini

  • Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women

    Leila Dorling;Sara Carvalho;Jamie Allen

  • Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

    Kyriaki Michailidou;Jonathan Beesley;Sara Lindstrom;Sander Canisius

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

    Nasim Mavaddat;Paul D.P. Pharoah;Kyriaki Michailidou;Jonathan Tyrer

  • MicroRNA related polymorphisms and breast cancer risk

    Sofia Khan;Dario Greco;Dario Greco;Kyriaki Michailidou;Roger L. Milne;Roger L. Milne

  • Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.

    Shahana Ahmed;Gilles Thomas;Maya Ghoussaini;Catherine S. Healey

  • Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics

    Montserrat Garcia-Closas;Per Hall;Heli Nevanlinna;Karen Pooley

  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

    Roger L Milne;Roger L Milne;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Kyriaki Michailidou;Kyriaki Michailidou;Jonathan Beesley

  • TP53 germline mutation testing in 180 families suspected of Li–Fraumeni syndrome: mutation detection rate and relative frequency of cancers in different familial phenotypes

    Marielle W. G. Ruijs;Senno Verhoef;Matti A. Rookus;Roelof Pruntel

  • Genome-wide association analysis identifies three new breast cancer susceptibility loci

    Maya Ghoussaini;Olivia Fletcher;Kyriaki Michailidou;Clare Turnbull

  • Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

    Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Lesley McGuffog;Daniel Barrowdale;Andrew Lee

  • Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations

    Timothy R. Rebbeck;Tara M. Friebel;Eitan Friedman;Ute Hamann

  • Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study

    Elizabeth K. Bancroft;Elizabeth C. Page;Elena Castro;Hans Lilja

  • Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK)

    Anouk Pijpe;Nadine Andrieu;Nadine Andrieu;Nadine Andrieu;Douglas F Easton;Ausrele Kesminiene

  • Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

    Antonis C. Antoniou;Jonathan Beesley;Lesley McGuffog;Olga M. Sinilnikova

  • Breast Cancer Risk After Salpingo-Oophorectomy in Healthy BRCA1/2 Mutation Carriers: Revisiting the Evidence for Risk Reduction

    B. A. M. Heemskerk-Gerritsen;C. Seynaeve;C. J. van Asperen;M. G. E. M. Ausems

  • Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: Findings from the Breast Cancer Association Consortium

    Annegien Broeks;Marjanka K. Schmidt;Mark E. Sherman;Fergus J. Couch

  • Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers

    Elizabeth C. Page;Elizabeth K. Bancroft;Mark N. Brook;Melissa Assel

Frequent Co-Authors

Peter Devilee
Peter Devilee Leiden University Medical Center
Irene L. Andrulis
Irene L. Andrulis University of Toronto
Melissa C. Southey
Melissa C. Southey Monash University
Roger L. Milne
Roger L. Milne Cancer Council Victoria
Graham G. Giles
Graham G. Giles University of Melbourne
Douglas F. Easton
Douglas F. Easton University of Cambridge
Fergus J. Couch
Fergus J. Couch Mayo Clinic
Hiltrud Brauch
Hiltrud Brauch German Cancer Research Center
Javier Benitez
Javier Benitez Instituto de Salud Carlos III
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute

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