Yasuko Orba

Best Publications

• Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

  Unknown

  760
  Citations

• Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

  Unknown

  738
  Citations

• Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo

  Kenichi Niikura;Tatsuya Matsunaga;Tadaki Suzuki;Shintaro Kobayashi

  678
  Citations

• Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike

  Unknown

  522
  Citations

• Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I

  Hideki Hasegawa;Hirofumi Sawa;Martha J Lewis;Martha J Lewis;Yasuko Orba

  346
  Citations

• The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

  Shigetomo Fukuhara;Szandor Simmons;Shunsuke Kawamura;Asuka Inoue

  342
  Citations

• SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells.

  Michihito Sasaki;Kentaro Uemura;Akihiko Sato;Shinsuke Toba

  242
  Citations

• RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells.

  Taisho Yamada;Seiichi Sato;Yuki Sotoyama;Yasuko Orba

  242
  Citations

• Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure

  Jun Nakae;Yongheng Cao;Miyo Oki;Yasuko Orba

  224
  Citations

• The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin

  Tadaki Suzuki;Yasuko Orba;Yuki Okada;Yuji Sunden

  188
  Citations

• Virological characteristics of SARS-CoV-2 BA.2 variant

  Unknown

  187
  Citations

• SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis.

  Ji-Seung Yoo;Michihito Sasaki;Steven X Cho;Yusuke Kasuga

  175
  Citations

• S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters

  Unknown

  129
  Citations

• A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin

  Tomohiro Omura;Masayuki Kaneko;Masayuki Kaneko;Yasunobu Okuma;Yasunobu Okuma;Yasuko Orba

  116
  Citations

• Large T Antigen Promotes JC Virus Replication in G2-arrested Cells by Inducing ATM- and ATR-mediated G2 Checkpoint Signaling

  Yasuko Orba;Tadaki Suzuki;Yoshinori Makino;Kanako Kubota

  111
  Citations

• Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role in nuclear egress of viral particles

  Yuki Okada;Tadaki Suzuki;Yuji Sunden;Yasuko Orba

  107
  Citations

• Inhibition of the SDF-1α–CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice

  Akira Kawaguchi;Akira Kawaguchi;Yasuko Orba;Takashi Kimura;Hidekatsu Iha

  96
  Citations

• Identification of FEZ1 as a Protein That Interacts with JC Virus Agnoprotein and Microtubules ROLE OF AGNOPROTEIN-INDUCED DISSOCIATION OF FEZ1 FROM MICROTUBULES IN VIRAL PROPAGATION

  Tadaki Suzuki;Yuki Okada;Shingo Semba;Yasuko Orba

  94
  Citations

• A novel nairovirus associated with acute febrile illness in Hokkaido, Japan.

  Fumihiro Kodama;Hiroki Yamaguchi;Eunsil Park;Kango Tatemoto

  94
  Citations

• Animal Models of Emerging Tick-Borne Phleboviruses: Determining Target Cells in a Lethal Model of SFTSV Infection.

  Keita Matsuno;Keita Matsuno;Yasuko Orba;Kimberly Maede-White;Dana Scott

  88
  Citations