Toshihiko Yada

Best Publications

• Ghrelin is present in pancreatic α-cells of humans and rats and stimulates insulin secretion

  Yukari Date;Masamitsu Nakazato;Suzuko Hashiguchi;Katsuya Dezaki

  870
  Citations

• Ghrelin Directly Interacts With Neuropeptide-Y-Containing Neurons in the Rat Arcuate Nucleus: Ca2+ Signaling via Protein Kinase A and N-Type Channel-Dependent Mechanisms and Cross-Talk With Leptin and Orexin

  Daisuke Kohno;Hong-Zhi Gao;Shinji Muroya;Sakae Kikuyama

  534
  Citations

• Endogenous Ghrelin in Pancreatic Islets Restricts Insulin Release by Attenuating Ca2+ Signaling in β-Cells Implication in the Glycemic Control in Rodents

  Katsuya Dezaki;Hiroshi Hosoda;Masafumi Kakei;Suzuko Hashiguchi

  515
  Citations

• Peripheral Administration of Nesfatin-1 Reduces Food Intake in Mice: The Leptin-Independent Mechanism

  H. Shimizu;S. Oh-I;K. Hashimoto;M. Nakata

  411
  Citations

• Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway.

  Yuko Maejima;Udval Sedbazar;Shigetomo Suyama;Daisuke Kohno

  409
  Citations

• Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats.

  Y. Oomura;N. Hori;T. Shiraishi;K. Fukunaga

  384
  Citations

• Nesfatin-1 Neurons in Paraventricular and Supraoptic Nuclei of the Rat Hypothalamus Coexpress Oxytocin and Vasopressin and Are Activated by Refeeding

  Daisuke Kohno;Masanori Nakata;Yuko Maejima;Hiroyuki Shimizu

  359
  Citations

• Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus

  Shinji Muroya;Shinji Muroya;Hisayuki Funahashi;Akihiro Yamanaka;Daisuke Kohno

  340
  Citations

• Leptin promotes aggregation of human platelets via the long form of its receptor.

  M Nakata;T Yada;N Soejima;I Maruyama

  335
  Citations

• Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet β-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release

  Ken Fujiwara;Fumihiko Maekawa;Toshihiko Yada

  325
  Citations

• Immunohistochemical localization of leptin receptor in the rat brain

  Seiji Shioda;Hisayuki Funahashi;Shigeo Nakajo;Toshihiko Yada

  317
  Citations

• Blockade of Pancreatic Islet–Derived Ghrelin Enhances Insulin Secretion to Prevent High-Fat Diet–Induced Glucose Intolerance

  Katsuya Dezaki;Hideyuki Sone;Masaru Koizumi;Masanori Nakata

  316
  Citations

• Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass

  Yuko Maejima;Yusaku Iwasaki;Yui Yamahara;Misato Kodaira

  294
  Citations

• Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y

  Shinji Muroya;Toshihiko Yada;Seiji Shioda;Morikuni Takigawa

  291
  Citations

• The liver-brain-gut neural arc maintains the Treg cell niche in the gut.

  Toshiaki Teratani;Yohei Mikami;Nobuhiro Nakamoto;Takahiro Suzuki

  254
  Citations

• Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells.

  Unknown

  253
  Citations

• Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins.

  Yun Zhu;Yoshihiro Miwa;Akihiro Yamanaka;Toshihiko Yada

  237
  Citations

• Ghrelin Uses Gαi2 and Activates Voltage-Dependent K+ Channels to Attenuate Glucose-Induced Ca2+ Signaling and Insulin Release in Islet β-Cells: Novel Signal Transduction of Ghrelin

  Katsuya Dezaki;Masafumi Kakei;Toshihiko Yada

  236
  Citations

• Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis

  Katsuya Dezaki;Hedeyuki Sone;Toshihiko Yada

  209
  Citations

• Short-chain fatty acids suppress food intake by activating vagal afferent neurons.

  Chayon Goswami;Yusaku Iwasaki;Yusaku Iwasaki;Toshihiko Yada

  206
  Citations