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Chemistry

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70
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5981
National Ranking
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Overview

Thomas Happe is affiliated with Ruhr University Bochum in Germany. Their research primarily focuses on topics related to energy and biochemistry, genetics, and molecular biology. The scientist's work extensively covers subfields such as renewable energy, sustainability and the environment, molecular biology, catalysis, electrical and electronic engineering, and materials chemistry.

The main topics addressed in Thomas Happe's research include:

  • Metalloenzymes and iron-sulfur proteins
  • Electrocatalysts for energy conversion
  • Ammonia synthesis and nitrogen reduction
  • Photosynthetic processes and mechanisms
  • Hydrogen storage and materials
  • Advanced battery technologies research
  • Metal-catalyzed oxygenation mechanisms

Recent papers from Thomas Happe demonstrate a focus on hydrogenase enzymes and proton-coupled electron transfer, as well as molecular mechanisms related to photosynthesis and catalyst stabilization. Selected publications include:

  • "A safety cap protects hydrogenase from oxygen attack," 2021, Nature Communications
  • "The roles of long-range proton-coupled electron transfer in the directionality and efficiency of [FeFe]-hydrogenases," 2020, Proceedings of the National Academy of Sciences
  • "Shedding Light on Proton and Electron Dynamics in [FeFe] Hydrogenases," 2020, Journal of the American Chemical Society
  • "Modelling Photosynthesis with ZnII-Protoporphyrin All-DNA G-Quadruplex/Aptamer Scaffolds," 2020, Angewandte Chemie International Edition
  • "Cyanide Binding to [FeFe]-Hydrogenase Stabilizes the Alternative Configuration of the Proton Transfer Pathway," 2022, Angewandte Chemie International Edition

Frequent coauthors in Thomas Happe's research include Vera Engelbrecht, Jifu Duan, Ulf-Peter Apfel, Anja Hemschemeier, and Martin Winkler. The collaboration network suggests a strong interdisciplinary approach involving multiple specialists.

Thomas Happe's work has appeared in several prominent publication venues. These include:

  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • Journal of the American Chemical Society
  • Proceedings of the National Academy of Sciences
  • Chemical Science

The research outputs from Thomas Happe contribute to understanding energy conversion processes, particularly via bioinspired catalysts and metalloenzymes, and emphasize molecular mechanisms underpinning sustainability and renewable energy technologies.

Best Publications

  • Hydrogen Production. Green Algae as a Source of Energy

    Anastasios Melis;Thomas Happe

  • Biomimetic assembly and activation of [FeFe]-hydrogenases

    Gustav Berggren;Gustav Berggren;Gustav Berggren;A. Adamska;C. Lambertz;T. R. Simmons

  • Biochemical and morphological characterization of sulfur-deprived and H2-producing Chlamydomonas reinhardtii (green alga).

    Liping Zhang;Thomas Happe;Anastasios Melis

  • Isolation, characterization and N‐terminal amino acid sequence of hydrogenase from the green alga Chlamydomonas reinhardtii

    Thomas Happe;J. Dirk Naber

  • How oxygen attacks [FeFe] hydrogenases from photosynthetic organisms.

    Sven T. Stripp;Gabrielle Goldet;Caterina Brandmayr;Oliver Sanganas

  • Spontaneous activation of [FeFe]-hydrogenases by an inorganic [2Fe] active site mimic

    Julian Esselborn;Camilla Lambertz;Agnieszka Adamska-Venkatesh;Trevor Simmons

  • A Novel Type of Iron Hydrogenase in the Green AlgaScenedesmus obliquus Is Linked to the Photosynthetic Electron Transport Chain

    Lore Florin;Anestis Tsokoglou;Thomas Happe

  • Differential regulation of the Fe-hydrogenase during anaerobic adaptation in the green alga Chlamydomonas reinhardtii.

    Thomas Happe;Annette Kaminski

  • Expression of two [Fe]-hydrogenases in Chlamydomonas reinhardtii under anaerobic conditions.

    Marc Forestier;Paul King;Liping Zhang;Matthew Posewitz

  • The surprising diversity of clostridial hydrogenases: a comparative genomic perspective

    Magdalena Calusinska;Thomas Happe;Bernard Joris;Annick Wilmotte

  • Hydrogen production by Chlamydomonas reinhardtii : an elaborate interplay of electron sources and sinks

    Anja Hemschemeier;Swanny Fouchard;Laurent Cournac;Gilles Peltier

  • Identification and Characterization of the “Super-Reduced” State of the H-Cluster in [FeFe] Hydrogenase: A New Building Block for the Catalytic Cycle?†

    Agnieszka Adamska;Alexey Silakov;Camilla Lambertz;Olaf Rüdiger

  • Induction, localization and metal content of hydrogenase in the green alga Chlamydomonas reinhardtii

    Thomas Happe;Britta Mosler;J. Dirk Naber

  • Transcriptional and mutational analysis of the uptake hydrogenase of the filamentous cyanobacterium Anabaena variabilis ATCC 29413.

    Thomas Happe;Kathrin Schütz;Herbert Böhme

  • Analytical approaches to photobiological hydrogen production in unicellular green algae.

    Anja Hemschemeier;Anastasios Melis;Thomas Happe

  • Cyanobacterial H2 production - a comparative analysis

    Kathrin Schütz;Thomas Happe;Olga Troshina;Olga Troshina;Peter Lindblad

  • Hydrogenases in green algae: do they save the algae's life and solve our energy problems?

    Thomas Happe;Anja Hemschemeier;Martin Winkler;Annette Kaminski

  • Electrochemical kinetic investigations of the reactions of [FeFe]-hydrogenases with carbon monoxide and oxygen: comparing the importance of gas tunnels and active-site electronic/redox effects.

    Gabrielle Goldet;Caterina Brandmayr;Sven T Stripp;Thomas Happe

  • Control of Hydrogen Photoproduction by the Proton Gradient Generated by Cyclic Electron Flow in Chlamydomonas reinhardtii

    Dimitri Tolleter;Dimitri Tolleter;Dimitri Tolleter;Bart Ghysels;Bart Ghysels;Bart Ghysels;Jean Alric;Dimitris Petroutsos

  • Autotrophic and Mixotrophic Hydrogen Photoproduction in Sulfur-Deprived Chlamydomonas Cells

    Swanny Fouchard;Anja Hemschemeier;Amandine Caruana;Jérémy Pruvost

Frequent Co-Authors

Wolfgang Lubitz
Wolfgang Lubitz Max Planck Society
Michael Haumann
Michael Haumann Freie Universität Berlin
Fraser A. Armstrong
Fraser A. Armstrong University of Oxford
Anastasios Melis
Anastasios Melis University of California, Berkeley
Gilles Peltier
Gilles Peltier CEA Cadarache
Laurent Cournac
Laurent Cournac Aix-Marseille University
Joachim Heberle
Joachim Heberle Freie Universität Berlin
Marc Fontecave
Marc Fontecave Collège de France
Michael Hippler
Michael Hippler University of Münster
Donald A. Bryant
Donald A. Bryant Pennsylvania State University

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