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Biology and Biochemistry

D-Index
80
Citations
55574
World Ranking
3978
National Ranking
1961

Overview

Sooryanarayana Varambally is affiliated with the University of Alabama at Birmingham in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a total of 118 and 112 publications in these areas respectively.

Their subfields of study include Molecular Biology, Oncology, Cancer Research, Pulmonary and Respiratory Medicine, and Surgery. These subfields reflect a focus on understanding biological mechanisms and disease processes at a molecular level as well as clinical applications related to cancer and respiratory systems.

Key research topics covered by Varambally include:

  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • RNA Modifications and Cancer
  • Ferroptosis and Cancer Prognosis
  • Pancreatic and Hepatic Oncology Research
  • Prostate Cancer Treatment and Research
  • Cancer, Hypoxia, and Metabolism

Varambally has collaborated extensively with several researchers, frequently co-authoring publications with:

  • Darshan S. Chandrashekar
  • Upender Manne
  • Sameer Al Diffalha
  • Prachi Bajpai
  • Farrukh Afaq

Their work has been published in various scholarly venues. The most common journals and platforms where their research appeared are:

  • Cancer Research
  • Translational Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neoplasia
  • SSRN Electronic Journal

Varambally's recent published papers include:

  • UALCAN: An update to the integrated cancer data analysis platform (2022, Neoplasia)
  • EZH2-Targeted Therapies in Cancer: Hype or a Reality (2020, Cancer Research)
  • Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways (2022, Nature Communications)
  • ARID1A-deficient bladder cancer is dependent on PI3K signaling and sensitive to EZH2 and PI3K inhibitors (2022, JCI Insight)
  • TRIP13 promotes metastasis of colorectal cancer regardless of p53 and microsatellite instability status (2020, Molecular Oncology)

Best Publications

  • UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses.

    Darshan S. Chandrashekar;Bhuwan Bashel;Sai Akshaya Hodigere Balasubramanya;Chad J. Creighton

  • Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer

    S.A. Tomlins;D.R. Rhodes;S. Perner;S.M. Dhanasekaran

  • The polycomb group protein EZH2 is involved in progression of prostate cancer

    Sooryanarayana Varambally;Saravana M. Dhanasekaran;Ming Zhou;Terrence R. Barrette

  • Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

    Arun Sreekumar;Laila M. Poisson;Thekkelnaycke M. Rajendiran;Amjad P. Khan

  • Delineation of prognostic biomarkers in prostate cancer

    Saravana M. Dhanasekaran;Terrence R. Barrette;Debashis Ghosh;Rajal Shah

  • EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

    Celina G. Kleer;Qi Cao;Sooryanarayana Varambally;Ronglai Shen

  • Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

    Himisha Beltran;Himisha Beltran;Davide Prandi;Juan Miguel Mosquera;Juan Miguel Mosquera;Matteo Benelli

  • Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

    Sooryanarayana Varambally;Qi Cao;Ram Shankar Mani;Sunita Shankar

  • Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer

    Scott A. Tomlins;Bharathi Laxman;Saravana M. Dhanasekaran;Beth E. Helgeson

  • An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression

    Jindan Yu;Jianjun Yu;Ram Shankar Mani;Qi Cao

  • Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression.

    Sooryanarayana Varambally;Jianjun Yu;Bharathi Laxman;Daniel R. Rhodes

  • α-Methylacyl Coenzyme A Racemase as a Tissue Biomarker for Prostate Cancer

    Mark A. Rubin;Ming Zhou;Saravana M. Dhanasekaran;Sooryanarayana Varambally

  • Role of the TMPRSS2-ERG gene fusion in prostate cancer

    Scott A. Tomlins;Bharathi Laxman;Sooryanarayana Varambally;Xuhong Cao

  • Autoantibody Signatures in Prostate Cancer

    X. Wang;J. Yu;A. Sreekumar;S. Varambally

  • Repression of E-cadherin by the polycomb group protein EZH2 in cancer

    Qi Cao;J. Yu;S. M. Dhanasekaran;J. H. Kim

  • Rearrangements of the RAF Kinase Pathway in Prostate Cancer, Gastric Cancer and Melanoma

    Nallasivam Palanisamy;Bushra Ateeq;Shanker Kalyana-Sundaram;Dorothee Pflueger;Dorothee Pflueger

  • Probabilistic model of the human protein-protein interaction network.

    Daniel R Rhodes;Scott A Tomlins;Sooryanarayana Varambally;Vasudeva Mahavisno

  • Mechanisms of Enhanced Radiation Response following Epidermal Growth Factor Receptor Signaling Inhibition by Erlotinib (Tarceva)

    Prakash Chinnaiyan;Shyhmin Huang;Geetha Vallabhaneni;Eric Armstrong

  • Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.

    J. Chad Brenner;Bushra Ateeq;Yong Li;Anastasia K. Yocum

  • Profiling of Cancer Cells Using Protein Microarrays Discovery of Novel Radiation-regulated Proteins

    Arun Sreekumar;Mukesh K. Nyati;Sooryanarayana Varambally;Terrence R. Barrette

Frequent Co-Authors

Arul M. Chinnaiyan
Arul M. Chinnaiyan University of Michigan–Ann Arbor
Scott A. Tomlins
Scott A. Tomlins University of Michigan–Ann Arbor
Mark A. Rubin
Mark A. Rubin University of Bern
Nallasivam Palanisamy
Nallasivam Palanisamy Henry Ford Health System
Rohit Mehra
Rohit Mehra University of Michigan–Ann Arbor
Xuhong Cao
Xuhong Cao University of Michigan–Ann Arbor
Jindan Yu
Jindan Yu Emory University
Kenneth J. Pienta
Kenneth J. Pienta Johns Hopkins University School of Medicine
Saravana M. Dhanasekaran
Saravana M. Dhanasekaran University of Michigan–Ann Arbor
Debashis Ghosh
Debashis Ghosh University of Colorado Anschutz Medical Campus

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