World's Best Scientists 2026 revealed!
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Chemistry
Japan
2026

D-Index & Metrics

Chemistry

D-Index
98
Citations
34237
World Ranking
1397
National Ranking
64

Research.com Recognitions

  • 2026 - Research.com Chemistry in Japan Leader Award
  • 2025 - Research.com Chemistry in Japan Leader Award
  • 2022 - Research.com Chemistry in Japan Leader Award

Overview

Motoo Shiro is affiliated with the Nagoya Institute of Technology in Japan. Their research primarily focuses on immunology, microbiology, and medicine with specific attention to several subfields including immunology, parasitology, epidemiology, oncology, and infectious diseases.

The scientist's main topics of work cover a variety of areas:

  • Vector-borne infectious diseases
  • Immunotherapy and immune responses
  • Cancer immunotherapy and biomarkers
  • Herpesvirus infections and treatments
  • Immune cell function and interaction
  • Bird parasitology and diseases
  • Veterinary oncology research

Motoo Shiro has contributed to numerous publications, frequently appearing in certain scientific journals and venues. These include:

  • Frontiers in Veterinary Science
  • PLoS ONE
  • Journal of Veterinary Medical Science
  • Vaccines
  • Veterinary Immunology and Immunopathology

They have collaborated extensively with several researchers, including:

  • Satoru Konnai
  • Kazuhiko Ohashi
  • Naoya Maekawa
  • Tomohiro Okagawa
  • Yasuhiko Suzuki

Motoo Shiro's recent published papers highlight their involvement in immunotherapy and veterinary medical science. Some notable works are:

  • "PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma" (2021) published in npj Precision Oncology
  • "Upregulation of PD-L1 Expression by Prostaglandin E2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection" (2020) published in Frontiers in Veterinary Science
  • "Distinct polymorphisms in a single herpesvirus gene are capable of enhancing virulence and mediating vaccinal resistance" (2020) published in PLoS Pathogens
  • "Direct evidence of the preventive effect of milk replacer-based probiotic feeding in calves against severe diarrhea" (2021) published in Veterinary Microbiology
  • "Enhanced Immunotherapeutic Efficacy of Anti-PD-L1 Antibody in Combination with an EP4 Antagonist" (2020) published in ImmunoHorizons

Best Publications

  • Synthesis and X-ray structure of dumb-bell-shaped C 120

    Guan-Wu Wang;Koichi Komatsu;Yasujiro Murata;Motoo Shiro

  • A zinc(II) complex of 1,5,9-triazacyclododecane ([12]aneN3) as a model for carbonic anhydrase

    Eiichi Kimura;Takeshi Shiota;Tohru Koike;Motoo Shiro

  • (S)-3,3‘-Dimethyl-2,2‘-biquinoline N,N‘-Dioxide as an Efficient Catalyst for Enantioselective Addition of Allyltrichlorosilanes to Aldehydes

    Makoto Nakajima;Makoto Saito;Motoo Shiro;Shun-ichi Hashimoto

  • Asymmetric dearomatizing spirolactonization of naphthols catalyzed by spirobiindane-based chiral hypervalent iodine species.

    Toshifumi Dohi;Naoko Takenaga;Tomofumi Nakae;Yosuke Toyoda

  • A Tris(ZnII−1,4,7,10-tetraazacyclododecane) Complex as a New Receptor for Phosphate Dianions in Aqueous Solution

    Eiichi Kimura;Shin Aoki;Tohru Koike;Motoo Shiro

  • Intramolecular Nonbonded S···O Interaction Recognized in (Acylimino)thiadiazoline Derivatives as Angiotensin II Receptor Antagonists and Related Compounds

    Yoshimitsu Nagao;Terukage Hirata;Satoru Goto;Shigeki Sano

  • A NOVEL BIOMIMETIC ZINC(II)-FLUOROPHORE, DANSYLAMIDOETHYL-PENDANT MACROCYCLIC TETRAAMINE 1,4,7,10-TETRAAZACYCLODODECANE (CYCLEN)

    Tohru Koike;Tomohiko Watanabe;Shin Aoki;Eiichi Kimura

  • Cinchona Alkaloid Catalyzed Enantioselective Fluorination of Allyl Silanes, Silyl Enol Ethers, and Oxindoles

    Takehisa Ishimaru;Norio Shibata;Takao Horikawa;Naomi Yasuda

  • Tetra-n-butylammonium bromide-water (1/38).

    Wataru Shimada;Motoo Shiro;Hidemasa Kondo;Satoshi Takeya

  • Trifluoromethanesulfonyl hypervalent iodonium ylide for copper-catalyzed trifluoromethylthiolation of enamines, indoles, and β-keto esters.

    Yu-Dong Yang;Ayaka Azuma;Etsuko Tokunaga;Mikio Yamasaki

  • First observation of light-induced excited spin state trapping for an iron(III) complex [7]

    Shinya Hayami;Zhong-ze Gu;Motoo Shiro;Yasuaki Einaga

  • A water-soluble titanium complex for the selective synthesis of nanocrystalline brookite, rutile, and anatase by a hydrothermal method.

    Koji Tomita;Valery Petrykin;Makoto Kobayashi;Motoo Shiro

  • Novel "Multipoint" Molecular Recognition of Nucleobases by a New Zinc(II) Complex of Acridine-Pendant Cyclen (Cyclen = 1,4,7,10-Tetraazacyclododecane)

    Mitsuhiko Shionoya;Takuya Ikeda;Eiichi Kimura;Motoo Shiro

  • Enantioselective Fluorination Mediated by Cinchona Alkaloid Derivatives/Selectfluor Combinations: Reaction Scope and Structural Information for N-Fluorocinchona Alkaloids

    Norio Shibata;Emiko Suzuki;Toru Asahi;Motoo Shiro

  • Metal chelation-controlled twisted intramolecular charge transfer and its application to fluorescent sensing of metal ions and anions.

    Shin Aoki;Daisuke Kagata;Motoo Shiro;Kei Takeda

  • A new ternary zinc(II) complex with [12]aneN4 (=1,4,7,10-tetraazacyclododecane) and AZT (=3'-azido-3'-deoxythymidine). Highly selective recognition of thymidine and its related nucleosides by a zinc(II) macrocyclic tetraamine complex with novel complementary associations

    Mitsuhiko Shionoya;Eiichi Kimura;Motoo Shiro

  • Efficient incorporation of a copper hydroxypyridone base pair in DNA.

    Kentaro Tanaka;Atsushi Tengeiji;Tatsuhisa Kato;Namiki Toyama

  • Recognition of phosphate monoester dianion by an alkoxide-bridged dinuclear zinc(II) complex

    Eiji Kinoshita;Makoto Takahashi;Hironori Takeda;Motoo Shiro

  • A novel chiral porous metal-organic framework: asymmetric ring opening reaction of epoxide with amine in the chiral open space.

    Koichi Tanaka;Shinji Oda;Motoo Shiro

  • The catalytic carboxyester hydrolysis by a new zinc(II) complex with an alcohol-pendant cyclen (1-(2-hydroxyethyl)-1,4,7,10-tetraazacyclododecane): A novel model for indirect activation of the serine nucleophile by zinc(II) in zinc enzymes

    Tohru Koike;Satoko Kajitani;Ikushi Nakamura;Eiichi Kimura

Frequent Co-Authors

Norio Shibata
Norio Shibata Nagoya Institute of Technology
Mitsuhiko Shionoya
Mitsuhiko Shionoya University of Tokyo
Masahito Ochiai
Masahito Ochiai University of Tokushima
Eiichi Kimura
Eiichi Kimura Hiroshima University
Tohru Koike
Tohru Koike Hiroshima University
Hiroshi Morita
Hiroshi Morita Hoshi University
Shin Aoki
Shin Aoki Tokyo University of Science
Shuichi Nakamura
Shuichi Nakamura Nagoya Institute of Technology
Shunichi Fukuzumi
Shunichi Fukuzumi Osaka University
Takahiko Kojima
Takahiko Kojima University of Tsukuba

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