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Physics

D-Index
86
Citations
31277
World Ranking
2514
National Ranking
1248

Overview

John C. H. Spence is affiliated with Arizona State University in the United States. Their research covers a broad range of topics within medicine, biochemistry, genetics, molecular biology, and materials science. The primary fields of study include Medicine, Biochemistry, Genetics and Molecular Biology, and Materials Science, supported by significant work in subfields such as Materials Chemistry and Molecular Biology.

The scientist's research emphasizes enzymology and structural biology, with main topics involving enzyme structure and function, biochemical and molecular research, protein structure and dynamics, and crystallization and solubility studies. Additional focus areas include liver disease diagnosis and treatment, endoplasmic reticulum stress and disease, and acute lymphoblastic leukemia research.

Frequent publication venues reflect interdisciplinary research linking structural and biological sciences with materials science. These venues include:

  • Nature Communications
  • IUCrJ
  • Journal of Applied Crystallography
  • Cell & Bioscience
  • Acta Crystallographica Section F Structural Biology Communications

Spence's recent papers demonstrate an engagement with advanced crystallographic techniques, particularly at X-ray free-electron lasers, reflecting an interest in dynamic biochemical processes and technologies for structural studies. Selected publications include:

  • Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography, 2021, IUCrJ
  • Segmented flow generator for serial crystallography at the European X-ray free electron laser, 2020, Nature Communications
  • Synchronous RNA conformational changes trigger ordered phase transitions in crystals, 2021, Nature Communications
  • Co-flow injection for serial crystallography at X-ray free-electron lasers, 2021, Journal of Applied Crystallography
  • Enhanced X-ray diffraction of in vivo-grown μNS crystals by viscous jets at XFELs, 2020, Acta Crystallographica Section F Structural Biology Communications

Collaborative work is a significant aspect of Spence's research, with frequent co-authors including Nadia A. Zatsepin, José M. Martín-García, Anton Barty, Henry N. Chapman, and Petra Fromme. Each co-author has contributed to multiple projects, indicating ongoing collaborative relationships in their research network.

Best Publications

  • Femtosecond X-ray protein nanocrystallography

    Henry N. Chapman;Petra Fromme;Anton Barty;Thomas A White

  • Single mimivirus particles intercepted and imaged with an X-ray laser

    M. Marvin Seibert;Tomas Ekeberg;Filipe R.N.C. Maia;Martin Svenda

  • X-ray image reconstruction from a diffraction pattern alone

    S. Marchesini;H. He;H. N. Chapman;S. P. Hau-Riege

  • High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography

    Sébastien Boutet;Lukas Lomb;Garth J. Williams;Thomas R. M. Barends

  • Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

    Yanyong Kang;X. Edward Zhou;Xiang Gao;Yuanzheng He

  • High-resolution ab initio three-dimensional x-ray diffraction microscopy

    Henry N. Chapman;Anton Barty;Stefano Marchesini;Aleksandr Noy

  • Gas Dynamic Virtual Nozzle for Generation of Microscopic Droplet Streams

    D.P. DePonte;U. Weierstall;D. Starodub;K. Schmidt

  • An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy

    M.R. Howells;T. Beetz;H.N. Chapman;C. Cui

  • Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein

    Jason Tenboer;Shibom Basu;Nadia Zatsepin;Kanupriya Pande

  • Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser.

    Christopher Kupitz;Shibom Basu;Ingo Grotjohann;Raimund Fromme

  • Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser

    Lars Redecke;Lars Redecke;Karol Nass;Daniel P. DePonte;Thomas A. White

  • Gas dynamic virtual nozzle for generation of microscopic droplet streams

    Robert Bruce Doak;John C. H. Spence;Uwe Weierstall;Daniel Deponte

  • Corrigendum: Diffraction data of core-shell nanoparticles from an X-ray free electron laser

    Xuanxuan Li;Chun Ya Chiu;Hsiang Ju Wang;Stephan Kassemeyer

  • High-Resolution Electron Microscopy

    John C. H. Spence

  • ALCHEMI: a new technique for locating atoms in small crystals

    J. C. H. Spence;J. Taftø

  • Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements

    Anton Barty;Carl Caleman;Andrew Aquila;Nicusor Timneanu

  • X-ray diffraction from isolated and strongly aligned gas-phase molecules with a free-electron laser

    Jochen Küpper;Stephan Stern;Lotte Holmegaard;Frank Filsinger

  • Time-resolved protein nanocrystallography using an X-ray free-electron laser

    Andrew Aquila;Mark S. Hunter;R. Bruce Doak;Richard A. Kirian

  • Science of Microscopy

    Peter W. Hawkes;John C. H. Spence

  • Injector for scattering measurements on fully solvated biospecies

    Uwe Weierstall;John Spence;R. B. Doak

Frequent Co-Authors

Henry N. Chapman
Henry N. Chapman Universität Hamburg
Petra Fromme
Petra Fromme Arizona State University
Anton Barty
Anton Barty Universität Hamburg
Jian-Min Zuo
Jian-Min Zuo University of Illinois at Urbana-Champaign
Marc Messerschmidt
Marc Messerschmidt SLAC National Accelerator Laboratory
Ilme Schlichting
Ilme Schlichting Max Planck Society
Michael O'Keeffe
Michael O'Keeffe Arizona State University
Richard Neutze
Richard Neutze University of Gothenburg
Dong Su
Dong Su Chinese Academy of Sciences
Vadim Cherezov
Vadim Cherezov University of Southern California

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