Howard C. Towle

Overview

Best Publications

• ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver.

  Lin Ma;Luke N. Robinson;Howard C. Towle

  491
  Citations

• Dual DNA Binding Specificity of ADD1/SREBP1 Controlled by a Single Amino Acid in the Basic Helix-Loop-Helix Domain

  J. B. Kim;G. D. Spotts;Yuan-Di Halvorsen;Hsiu-Ming Shih

  424
  Citations

• Regulation of the expression of lipogenic enzyme genes by carbohydrate.

  Howard C. Towle;Elizabeth N. Kaytor;Hsiu-Ming Shih

  423
  Citations

• Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors.

  M B Murray;N D Zilz;N L McCreary;M J MacDonald

  316
  Citations

• Two CACGTG Motifs with Proper Spacing Dictate the Carbohydrate Regulation of Hepatic Gene Transcription

  Hsiu-Ming Shih;Zheru Liu;Howard C. Towle

  296
  Citations

• Identification of nuclear factors that enhance binding of the thyroid hormone receptor to a thyroid hormone response element.

  Mary Beth Murray;Howard C. Towle

  287
  Citations

• Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes.

  Angela K. Stoeckman;Lin Ma;Howard C. Towle

  284
  Citations

• Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

  L K Olson;J B Redmon;H C Towle;R P Robertson

  256
  Citations

• The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression.

  Angela K. Stoeckman;Howard C. Towle

  247
  Citations

• Direct Role of ChREBP·Mlx in Regulating Hepatic Glucose-responsive Genes

  Lin Ma;Nikolas G. Tsatsos;Howard C. Towle

  247
  Citations

• Metabolic regulation of gene transcription in mammals.

  Howard C. Towle

  221
  Citations

• Thyroid hormone attenuates and augments hepatic gene expression at a pretranslational level.

  Steven Seelig;Chen Liaw;Howard C. Towle;Jack H. Oppenheimer

  220
  Citations

• Changes in the hepatic levels of messenger ribonucleic acid for malic enzyme during induction by thyroid hormone or diet.

  Howard C. Towle;Cary N. Mariash;Jack H. Oppenheimer

  219
  Citations

• Rapid effects of triiodothyronine on hepatic gene expression. Hybridization analysis of tissue-specific triiodothyronine regulation of mRNAS14.

  D B Jump;P Narayan;H Towle;J H Oppenheimer

  216
  Citations

• Definition of the carbohydrate response element of the rat S14 gene. Evidence for a common factor required for carbohydrate regulation of hepatic genes.

  Hsiu-Ming Shih;H. C. Towle

  211
  Citations

• Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver.

  Seung Hoi Koo;Angela K. Dutcher;Howard C. Towle

  211
  Citations

• Synergism of thyroid hormone and high carbohydrate diet in the induction of lipogenic enzymes in the rat. Mechanisms and implications.

  C N Mariash;F E Kaiser;H L Schwartz;H C Towle

  205
  Citations

• Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression

  L K Olson;A Sharma;M Peshavaria;C V Wright

  205
  Citations

• Glucose as a regulator of eukaryotic gene transcription.

  Howard C. Towle

  200
  Citations

• Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase.

  Marisa M. Magaña;Seung Hoi Koo;Howard C. Towle;Timothy F. Osborne

  197
  Citations