D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 53 Citations 9,275 96 World Ranking 11621 National Ranking 4991

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

Howard C. Towle mainly investigates Biochemistry, Transcription factor, Gene expression, Lipogenesis and Endocrinology. His research integrates issues of Molecular biology, Pyruvate kinase, Regulation of gene expression, Response element and Transcription in his study of Transcription factor. His Pyruvate kinase research incorporates themes from Carbohydrate metabolism and Pyruvate carboxylase.

His studies deal with areas such as Consensus sequence, Binding site and Cell nucleus as well as Transcription. As a part of the same scientific study, Howard C. Towle usually deals with the Gene expression, concentrating on Messenger RNA and frequently concerns with Euthyroid, Activator and Protein biosynthesis. His study in Endocrinology is interdisciplinary in nature, drawing from both Receptor and Internal medicine.

His most cited work include:

  • ChREBP•Mlx Is the Principal Mediator of Glucose-induced Gene Expression in the Liver (292 citations)
  • Regulation of the expression of lipogenic enzyme genes by carbohydrate. (268 citations)
  • Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors. (198 citations)

What are the main themes of his work throughout his whole career to date?

Biochemistry, Endocrinology, Internal medicine, Gene expression and Molecular biology are his primary areas of study. His study in Biochemistry focuses on Transcription factor, Gene, Carbohydrate-responsive element-binding protein, Pyruvate kinase and Response element. Carbohydrate metabolism and Fatty acid is closely connected to Lipogenesis in his research, which is encompassed under the umbrella topic of Transcription factor.

His Endocrinology research is multidisciplinary, relying on both Messenger RNA and Malic enzyme. His Internal medicine study incorporates themes from Rat liver and In vivo. In his study, Metabolic regulation is inextricably linked to Cell biology, which falls within the broad field of Gene expression.

He most often published in these fields:

  • Biochemistry (44.33%)
  • Endocrinology (39.18%)
  • Internal medicine (39.18%)

What were the highlights of his more recent work (between 2004-2013)?

  • Biochemistry (44.33%)
  • Carbohydrate-responsive element-binding protein (13.40%)
  • Transcription factor (29.90%)

In recent papers he was focusing on the following fields of study:

Howard C. Towle focuses on Biochemistry, Carbohydrate-responsive element-binding protein, Transcription factor, Lipogenesis and MLX. His work often combines Biochemistry and Fructose 2,6-bisphosphate studies. His Transcription factor research incorporates themes from Nuclear export signal, Protein kinase A, Phosphorylation, Response element and Transcription.

The subject of his Lipogenesis research is within the realm of Gene. Specifically, his work in Gene is concerned with the study of Gene expression. His work deals with themes such as Internal medicine and Endocrinology, which intersect with Gene expression.

Between 2004 and 2013, his most popular works were:

  • ChREBP•Mlx Is the Principal Mediator of Glucose-induced Gene Expression in the Liver (292 citations)
  • Direct Role of ChREBP·Mlx in Regulating Hepatic Glucose-responsive Genes (147 citations)
  • Glucose as a regulator of eukaryotic gene transcription. (125 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

His primary areas of investigation include Biochemistry, Carbohydrate-responsive element-binding protein, Transcription factor, Lipogenesis and MLX. His study in the field of Gene, Cell nucleus, Fructose and Response element is also linked to topics like Snf3. His Cell nucleus study combines topics in areas such as Mutation, Psychological repression and Repressor.

The study incorporates disciplines such as Glycolysis, Glucose 6-phosphatase, Phosphofructokinase 2 and Allosteric regulation in addition to Fructose. Promoter covers Howard C. Towle research in Response element. His MLX research includes elements of TBX1 and Microarray analysis techniques, Gene expression, Gene expression profiling.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

ChREBP•Mlx Is the Principal Mediator of Glucose-induced Gene Expression in the Liver

Lin Ma;Luke N. Robinson;Howard C. Towle.
Journal of Biological Chemistry (2006)

439 Citations

Regulation of the expression of lipogenic enzyme genes by carbohydrate.

Howard C. Towle;Elizabeth N. Kaytor;Hsiu-Ming Shih.
Annual Review of Nutrition (1997)

399 Citations

Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors.

M B Murray;N D Zilz;N L McCreary;M J MacDonald.
Journal of Biological Chemistry (1988)

314 Citations

Two CACGTG Motifs with Proper Spacing Dictate the Carbohydrate Regulation of Hepatic Gene Transcription

Hsiu-Ming Shih;Zheru Liu;Howard C. Towle.
Journal of Biological Chemistry (1995)

292 Citations

Identification of nuclear factors that enhance binding of the thyroid hormone receptor to a thyroid hormone response element.

Mary Beth Murray;Howard C. Towle.
Molecular Endocrinology (1989)

264 Citations

Mlx Is the Functional Heteromeric Partner of the Carbohydrate Response Element-binding Protein in Glucose Regulation of Lipogenic Enzyme Genes

Angela K. Stoeckman;Lin Ma;Howard C. Towle.
Journal of Biological Chemistry (2004)

257 Citations

Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

L K Olson;J B Redmon;H C Towle;R P Robertson.
Journal of Clinical Investigation (1993)

236 Citations

The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression.

Angela K. Stoeckman;Howard C. Towle.
Journal of Biological Chemistry (2002)

228 Citations

Direct Role of ChREBP·Mlx in Regulating Hepatic Glucose-responsive Genes

Lin Ma;Nikolas G. Tsatsos;Howard C. Towle.
Journal of Biological Chemistry (2005)

222 Citations

Metabolic regulation of gene transcription in mammals.

Howard C. Towle.
Journal of Biological Chemistry (1995)

218 Citations

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