Ribonuclease, RNase P, Biochemistry, Protein subunit and Enzyme are his primary areas of study. The Ribonuclease study combines topics in areas such as Homologous chromosome, Virology, Egg protein, Stereochemistry and Protein structure. Many of his research projects under RNase P are closely connected to Isopeptide bond with Isopeptide bond, tying the diverse disciplines of science together.
His studies deal with areas such as Molecular biology, S-tag, RNase PH and RNase MRP as well as Pancreatic ribonuclease. He integrates Biochemistry and Ribonuclease III in his research. His Protein subunit research incorporates elements of Residue and Peptide.
His scientific interests lie mostly in Biochemistry, RNase P, Ribonuclease, Enzyme and Molecular biology. His research in RNase P intersects with topics in Cytotoxic T cell, Stereochemistry and Cytosol. His study in Stereochemistry is interdisciplinary in nature, drawing from both Protein structure, Crystallography, Protein quaternary structure and Protein secondary structure.
His work on Bovine pancreatic ribonuclease as part of general Ribonuclease research is often related to Ribonuclease III, thus linking different fields of science. His study explores the link between Enzyme and topics such as Escherichia coli that cross with problems in Phosphoglycerate kinase. His biological study spans a wide range of topics, including Cell culture, Complementary DNA, Zebrafish, Biological activity and Isozyme.
Giuseppe D'Alessio mainly investigates RNase P, Immunotherapy, Biochemistry, Cancer research and Cancer cell. His work deals with themes such as Molecular biology and Enzyme, which intersect with RNase P. His Enzyme research includes elements of RNA and Gene.
His Immunotherapy research is multidisciplinary, incorporating perspectives in Receptor tyrosine kinase and Oncology. His Cancer research research focuses on subjects like Immunology, which are linked to Osteoblast and Cell culture. His Cancer cell research is multidisciplinary, incorporating elements of Trastuzumab, Epitope, Antibody, Monoclonal antibody and Cytotoxic T cell.
Giuseppe D'Alessio mainly focuses on Cardiotoxicity, In vivo, Pharmacology, Immunotherapy and RNase P. His In vivo study combines topics from a wide range of disciplines, such as Pertuzumab, Lapatinib, In vitro and DNA fragmentation. Giuseppe D'Alessio works mostly in the field of Immunotherapy, limiting it down to topics relating to Cancer cell and, in certain cases, Monoclonal antibody, Epitope, Monoclonal, Immunology and Cancer research, as a part of the same area of interest.
His RNase P study introduces a deeper knowledge of Biochemistry. His work on Vertebrate, Recombinant DNA and Molecular evolution is typically connected to Magic bullet as part of general Biochemistry study, connecting several disciplines of science. The various areas that he examines in his Molecular biology study include Cytoplasm, Nucleolus and Cell growth.
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Ribonucleases : structures and functions
Giuseppe D'Alessio;James F. Riordan.
Seminal RNase: a unique member of the ribonuclease superfamily
Giuseppe D'Alessio;Alberto Di Donato;Augusto Parente;Renata Piccoli.
Trends in Biochemical Sciences (1991)
The dual-mode quaternary structure of seminal RNase.
R Piccoli;M Tamburrini;G Piccialli;A Di Donato.
Proceedings of the National Academy of Sciences of the United States of America (1992)
[Bull semen ribonucleases. 1. Purification and physico-chemical properties of the major component].
Giuseppe D'Alessio;Ardesio Flobidi;Rocco De Prisco;Alberto Pignero.
FEBS Journal (1972)
New and cryptic biological messages from RNases.
Trends in Cell Biology (1993)
A Study of the Intracellular Routing of Cytotoxic Ribonucleases
YouNeng Wu;Shailendra K. Saxena;Wojciech Ardelt;Massimo Gadina.
Journal of Biological Chemistry (1995)
Ribonuclease A can be transformed into a dimeric ribonuclease with antitumor activity.
A. Di Donato;V. Cafaro;G. D'Alessio.
Journal of Biological Chemistry (1994)
Ribonuclease/angiogenin inhibitor 1 regulates stress-induced subcellular localization of angiogenin to control growth and survival
Elio Pizzo;Carmen Sarcinelli;Carmen Sarcinelli;Jinghao Sheng;Sabato Fusco.
Journal of Cell Science (2013)
Dissociation of bovine seminal ribonuclease into catalytically active monomers by selective reduction and alkylation of the intersubunit disulfide bridges.
Giuseppe D'Alessio;Maria C. Malorni;Augusto Parente.
Selective deamidation and enzymatic methylation of seminal ribonuclease.
A. Di Donato;P. Galletti;G. D'alessio.
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