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Gijs R. van den Brink

Gijs R. van den Brink

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
21139
World Ranking
15896
National Ranking
296

Overview

Gijs R. van den Brink is affiliated with Roche (Switzerland) and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans several subfields, including molecular biology, cell biology, genetics, oncology, and infectious diseases.

Their research topics cover diverse areas such as cellular transport and secretion, lipid membrane structure and behavior, Bacillus and Francisella bacterial research, endoplasmic reticulum stress and disease, SARS-CoV-2 and COVID-19 research, bacterial genetics and biotechnology, and cancer cells and metastasis.

Frequent publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Developmental Cell
  • Cellular and Molecular Gastroenterology and Hepatology
  • SSRN Electronic Journal

Notable recent papers authored or co-authored by Gijs R. van den Brink include:

  • A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial, 2024, The Lancet. Gastroenterology & Hepatology
  • Mechanisms and functions of protein S-acylation, 2024, Nature Reviews Molecular Cell Biology
  • S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity, 2021, Developmental Cell
  • A high proportion of novel mutations in BRCA1 with strong founder effects among Dutch and Belgian hereditary breast and ovarian cancer families, 2020, PubMed
  • Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity, 2020, Proceedings of the National Academy of Sciences

Frequent co-authors associated with their work include Laurence Abrami, Francisco S. Mesquita, Béatrice Kunz, Didier Trono, and Vanesa Muncan.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn’s disease

    Jan M.H Van den Brande;Henri Braat;Gijs R van den Brink;Henri H Versteeg

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis.

    Marjolijn Duijvestein;Manon E. Wildenberg;Mick M. Welling;Simone Hennink

  • Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon.

    James C.H. Hardwick;Gijs R. Van Den Brink;Sylvia A. Bleuming;Isabel Ballester

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

    Jarom y Heijmans;Jooske F. van Lidth de Jeude;Bon-Kyoung Koo;Sanne L Rosekrans

  • Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling

    Pim J Koelink;Felicia M Bloemendaal;Bofeng Li;Liset Westera

  • Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro

    Anne Christine W. Vos;Manon E. Wildenberg;Manon E. Wildenberg;Ingrid Arijs;Marjolijn Duijvestein

  • The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers

    Liudmila L. Kodach;Eliza Wiercinska;Noel F.C.C. de Miranda;Sylvia A. Bleuming

  • Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

    Philip W. Voorneveld;Liudmila L. Kodach;Rutger J. Jacobs;Nalan Liv

  • Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell ‘stemness’ via the bone morphogenetic protein pathway

    Liudmila L Kodach;Rutger J Jacobs;Philip W Voorneveld;Manon E Wildenberg

  • Blimp1 regulates the transition of neonatal to adult intestinal epithelium.

    Vanesa Muncan;Vanesa Muncan;Jarom Heijmans;Jarom Heijmans;Stephen D Krasinski;Nikè V. J. A. Büller;Nikè V. J. A. Büller

  • Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice.

    Sylvia A. Bleuming;Xi C. He;Liudmila L. Kodach;James C. Hardwick

  • Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

    Marco Gerling;Nikè V. J. A. Büller;Leonard M. Kirn;Leonard M. Kirn;Simon Joost

  • Impact of disease location on fecal calprotectin levels in Crohn's disease.

    Krisztina B Gecse;Johannan F Brandse;Sandra van Wilpe;Mark Löwenberg

  • Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones

    James M. Amos-Landgraf;Jarom Heijmans;Mattheus C. B. Wielenga;Elisa Dunkin

  • The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC.

    Ronald Schilderink;Caroline Verseijden;Jurgen Seppen;Vanesa Muncan

  • Expression and activation of NF-kappa B in the antrum of the human stomach.

    G. R. van den Brink;F. J. ten Kate;C. Y. Ponsioen;M. M. Rive

  • Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine

    Willemijn A. van Dop;Jarom Heijmans;Nikè V.J.A. Büller;Susanne A. Snoek

Frequent Co-Authors

Geert R. D'Haens
Geert R. D'Haens University of Amsterdam
Willem A. Bemelman
Willem A. Bemelman University of Amsterdam
Cyriel Y. Ponsioen
Cyriel Y. Ponsioen University of Amsterdam
Evelina Gatti
Evelina Gatti Aix-Marseille University
Jan Paul Medema
Jan Paul Medema University of Amsterdam
Jan Koster
Jan Koster University of Amsterdam
Hsing Jien Kung
Hsing Jien Kung Taipei Medical University
Maurizio Molinari
Maurizio Molinari Universita della Svizzera Italiana
Maikel P. Peppelenbosch
Maikel P. Peppelenbosch Erasmus University Rotterdam
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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