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Biology and Biochemistry

D-Index
73
Citations
17710
World Ranking
5986
National Ranking
2825

Overview

De-Quan Li is affiliated with Baylor College of Medicine in the United States and has contributed to the field of medicine with a particular focus on ocular surface and contact lens research. Their work spans various subfields including public health, environmental and occupational health, radiology, nuclear medicine and imaging, molecular biology, materials chemistry, and dermatology.

The primary research topics addressed by De-Quan Li include:

  • Ocular Surface and Contact Lens
  • Corneal Surgery and Treatments
  • Corneal Surgery and Disorders
  • Dermatology and Skin Diseases
  • Electrocatalysts for Energy Conversion
  • Thermochemical Biomass Conversion Processes
  • IL-33, ST2, and ILC Pathways

De-Quan Li has published extensively, contributing to journals with multiple papers. The frequent publication venues include:

  • The Ocular Surface
  • Investigative Ophthalmology & Visual Science
  • Mucosal Immunology
  • SSRN Electronic Journal
  • Journal of Alloys and Compounds

Representative recent papers by De-Quan Li include:

  • Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea (2020, The Ocular Surface)
  • Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus (2021, Investigative Ophthalmology & Visual Science)
  • Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress (2020, Investigative Ophthalmology & Visual Science)

Frequent co-authors associated with De-Quan Li's research include:

  • Stephen C. Pflugfelder
  • Jinmiao Li
  • Cintia S. de Paiva
  • Fang Bian
  • Yun Zhang

Their research contributions have been cited in various contexts, reflecting engagement with interdisciplinary topics such as corneal biology, inflammation, and stem cell populations within the ocular surface environment.

De-Quan Li's scientific output notably integrates molecular biology and dermatology aspects with ocular health, addressing conditions affecting the cornea and associated tissues. The research approach includes advanced techniques like single-cell transcriptomics to better understand stem cell dynamics in the eye.

Best Publications

  • SUPPRESSION OF TRANSFORMING GROWTH FACTOR-BETA ISOFORMS, TGF-BETA RECEPTOR TYPE II, AND MYOFIBROBLAST DIFFERENTIATION IN CULTURED HUMAN CORNEAL AND LIMBAL FIBROBLASTS BY AMNIOTIC MEMBRANE MATRIX

    Scheffer C.G. Tseng;Scheffer C.G. Tseng;De-Quan Li;Xiang Ma

  • Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface.

    Lihui Luo;De-Quan Li;Amish Doshi;William Farley

  • Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye.

    Cintia S. De Paiva;Rosa M. Corrales;Arturo L. Villarreal;William J. Farley

  • Characterization of putative stem cell phenotype in human limbal epithelia.

    Zhuo Chen;Cintia S. de Paiva;Lihui Luo;Francis L. Kretzer

  • IL-17 disrupts corneal barrier following desiccating stress.

    C. S. De Paiva;S. Chotikavanich;S. B. Pangelinan;J. D. Pitcher

  • Three patterns of cytokine expression potentially involved in epithelial-fibroblast interactions of human ocular surface.

    De‐Quan Li;Scheffer C. G. Tseng;Scheffer C. G. Tseng

  • Stimulation of Matrix Metalloproteinases by Hyperosmolarity via a JNK Pathway in Human Corneal Epithelial Cells

    De-Quan Li;Zhuo Chen;Xiu Jun Song;Xiu Jun Song;Lihui Luo

  • Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome.

    Suksri Chotikavanich;Cintia S. de Paiva;De Quan Li;Joseph J. Chen

  • Hyperosmolar Saline Is a Proinflammatory Stress on the Mouse Ocular Surface

    Lihui Luo;De-Quan Li;Rosa M Corrales;Stephen C Pflugfelder

  • Suppression of TGF-beta signaling in both normal conjunctival fibroblasts and pterygial body fibroblasts by amniotic membrane.

    Sao-Bing Lee;De-Quan Li;Donald T.H. Tan;Daniel Meller

  • JNK and ERK MAP kinases mediate induction of IL-1β, TNF-α and IL-8 following hyperosmolar stress in human limbal epithelial cells

    De-Quan Li;Lihui Luo;Zhuo Chen;Hyun-Seung Kim;Hyun-Seung Kim

  • Matrix Metalloproteinase-9 Knockout Confers Resistance to Corneal Epithelial Barrier Disruption in Experimental Dry Eye

    Stephen C. Pflugfelder;William Farley;Lihui Luo;Lucy Zhuo Chen

  • Dry Eye–Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-γ

    Cintia S. De Paiva;Arturo L. Villarreal;Rosa M. Corrales;Hassan T. Rahman

  • Apoptosis of ocular surface cells in experimentally induced dry eye.

    Steven Yeh;Xiu Jun Song;Xiu Jun Song;William Farley;De-Quan Li

  • ABCG2 TRANSPORTER IDENTIFIES A POPULATION OF CLONOGENIC HUMAN LIMBAL EPITHELIAL CELLS

    Cintia S. de Paiva;Zhuo Chen;Rosa M. Corrales;Stephen C. Pflugfelder

  • Regulation of MMP-9 Production by Human Corneal Epithelial Cells

    De Quan Li;Balakrishna L. Lokeshwar;Abraham Solomon;Dagoberto Monroy

  • A mouse model of keratoconjunctivitis sicca.

    Dilek Dursun;Min Wang;Dagoberto Monroy;De Quan Li

  • Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures.

    Hyun-Seung Kim;Xiu Jun Song;Xiu Jun Song;Cintia S de Paiva;Zhuo Chen

  • Doxycycline inhibition of interleukin-1 in the corneal epithelium

    Abraham Solomon;Mark Rosenblatt;De-Quan Li;Zuguo Liu

  • Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid.

    Stephen C. Pflugfelder;Zuguo Liu;Dagoberto Monroy;De Quan Li

Frequent Co-Authors

Stephen C. Pflugfelder
Stephen C. Pflugfelder Baylor College of Medicine
Michael E. Stern
Michael E. Stern University of Cologne
Jerry Y. Niederkorn
Jerry Y. Niederkorn The University of Texas Southwestern Medical Center
Daniel B. Jones
Daniel B. Jones Beth Israel Deaconess Medical Center
Christophe Baudouin
Christophe Baudouin Institut de la Vision
Alan R. Burns
Alan R. Burns University of Houston
Michael A. Barry
Michael A. Barry Mayo Clinic
Eric Pearlman
Eric Pearlman University of California, Irvine
Linda D. Hazlett
Linda D. Hazlett Wayne State University
Rui Chen
Rui Chen Capital Medical University

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