His scientific interests lie mostly in Immunology, Virology, Virus, Viral load and Viral replication. His Virology research integrates issues from HIV vaccine and Mononuclear phagocyte system. His Virus study introduces a deeper knowledge of Genetics.
His Viral load research is multidisciplinary, relying on both Hiv infected, Viremia, T cell and Simian immunodeficiency virus. His Viremia study combines topics from a wide range of disciplines, such as Gut-associated lymphoid tissue, Lymphatic system, T lymphocyte and Immunity. The study incorporates disciplines such as CD14, Bone marrow, In vivo and Immunodeficiency in addition to Viral replication.
David C. Nickle mainly focuses on Virology, Genetics, Virus, Immunology and Viral disease. The Virology study combines topics in areas such as Epitope, Antigen and CTL*. In general Genetics study, his work on Genetic variation, Phylogenetic tree, Gene and Recombination often relates to the realm of Substitution, thereby connecting several areas of interest.
David C. Nickle combines subjects such as SNP and Regulation of gene expression with his study of Immunology. His work on Lentivirus as part of general Viral disease study is frequently linked to Compartmentalization, therefore connecting diverse disciplines of science. His biological study spans a wide range of topics, including Viremia, Human leukocyte antigen and T cell.
David C. Nickle mostly deals with Genome-wide association study, Single-nucleotide polymorphism, Gene expression, Macrophage migration inhibitory factor and Pathogenesis. His Genome-wide association study study results in a more complete grasp of Genetics. His study in Single-nucleotide polymorphism is interdisciplinary in nature, drawing from both Asthma, Bioinformatics and Gene isoform.
The Gene expression study combines topics in areas such as SNP and Molecular biology. His SNP study frequently involves adjacent topics like Immunology. His research in Pathogenesis intersects with topics in Phenotype, Lesion and Knockout mouse.
David C. Nickle focuses on Genome-wide association study, Lesion, Pathogenesis, Coronary artery disease and Phenotype. His work deals with themes such as Mendelian Randomization Analysis, Quantitative trait locus, Expression quantitative trait loci, ABO blood group system and Human genetics, which intersect with Genome-wide association study. The various areas that David C. Nickle examines in his Lesion study include Knockout mouse and Genetic association.
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CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
Photini Kiepiela;Kholiswa Ngumbela;Christina Thobakgale;Dhanwanthie Ramduth.
Nature Medicine (2007)
Persistence of HIV in Gut-Associated Lymphoid Tissue despite Long-Term Antiretroviral Therapy
Tae Wook Chun;David C. Nickle;Jesse S. Justement;Jennifer H. Meyers.
The Journal of Infectious Diseases (2008)
Improved Coreceptor Usage Prediction and Genotypic Monitoring of R5-to-X4 Transition by Motif Analysis of Human Immunodeficiency Virus Type 1 env V3 Loop Sequences
Mark A. Jensen;Fu Sheng Li;Angélique B. Van 't Wout;David C. Nickle.
Journal of Virology (2003)
Aspergillus lentulus sp. nov., a New Sibling Species of A. fumigatus
S. Arunmozhi Balajee;Jennifer L. Gribskov;Edward Hanley;David Nickle.
Eukaryotic Cell (2005)
Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy.
Tuofu Zhu;David Muthui;Sarah Holte;David Nickle.
Journal of Virology (2002)
HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
Tae Wook Chun;David C. Nickle;J. Shawn Justement;Danielle Large.
Journal of Clinical Investigation (2005)
Elbasvir-Grazoprevir to Treat Hepatitis C Virus Infection in Persons Receiving Opioid Agonist Therapy: A Randomized Trial
Gregory J. Dore;Frederick Altice;Alain H. Litwin;Olav Dalgard.
Annals of Internal Medicine (2016)
Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma
Ke Hao;Yohan Bossé;David C. Nickle;Peter D. Paré.
PLOS Genetics (2012)
Cloning and Characterization of PDK4 on 7q21.3 Encoding a Fourth Pyruvate Dehydrogenase Kinase Isoenzyme in Human
Joie Rowles;Stephen W. Scherer;Tina Xi;Martin Majer.
Journal of Biological Chemistry (1996)
Founder effects in the assessment of HIV polymorphisms and HLA allele associations.
Tanmoy Bhattacharya;Tanmoy Bhattacharya;Marcus Daniels;David Heckerman;Brian Foley.
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