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Bernard L. Trumpower

Bernard L. Trumpower

D-Index & Metrics

Chemistry

D-Index
68
Citations
16257
World Ranking
6535
National Ranking
1984

Biology and Biochemistry

D-Index
67
Citations
15736
World Ranking
8234
National Ranking
3722

Overview

Bernard L. Trumpower was affiliated with Dartmouth College in the United States. Their research primarily focused on biochemical and molecular aspects of microbial organisms, investigating complex cellular mechanisms and drug interactions.

Their body of work included several recent publications, notably concentrating on the cytochrome bc1 complex and related mitochondrial functions. Key papers included:

  • DB75, a Novel Trypanocidal Agent, Disrupts Mitochondrial Function in Saccharomyces cerevisiae (2020, UNC Libraries)
  • Cytochrome b Mutations That Modify the Ubiquinol-binding Pocket of the Cytochrome bc 1 Complex and Confer Anti-malarial Drug Resistance in Saccharomyces cerevisiae (2021, UNC Libraries)
  • Molecular Basis for Atovaquone Binding to the Cytochrome bc 1 Complex (2021, UNC Libraries)
  • Recapitulation in Saccharomyces cerevisiae of Cytochrome b Mutations Conferring Resistance to Atovaquone in Pneumocystis jiroveci (2020, UNC Libraries)
  • Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex (2020, UNC Libraries)

The frequent collaborators in their research were:

  • Jacques J. Kessl (3 publications)
  • Benjamin B. Lange (2 publications)
  • Philip C. Hill (2 publications)
  • Brigitte Meunier (2 publications)
  • Steven R. Meshnick (2 publications)

Trumpower's research was regularly published in a single primary venue, UNC Libraries, accounting for five publications in the recent years.

The scientific subfields in which they contributed notably included:

  • Organic Chemistry
  • Molecular Biology
  • Epidemiology

The main topics addressed in their work encompassed:

  • Biochemical and Molecular Research
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Synthesis and Biological Evaluation
  • Synthesis and Reactions of Organic Compounds

Throughout their career, Bernard L. Trumpower contributed to the understanding of mitochondrial function and drug resistance mechanisms, particularly related to fungal and parasitic organisms. Their studies on cytochrome bc1 complex mutations and the biochemical evaluation of drug agents provided foundational insights relevant to infectious disease treatment research.

Best Publications

  • A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae

    Mark E. Schmitt;Timothy A. Brown;Bernard L. Trumpower

  • Simultaneous determination of hemes a, b, and c from pyridine hemochrome spectra

    Edward A. Berry;Bernard L. Trumpower

  • The protonmotive Q cycle. Energy transduction by coupling of proton translocation to electron transfer by the cytochrome bc1 complex.

    B L Trumpower

  • Energy Transduction by Cytochrome Complexes in Mitochondrial and Bacterial Respiration: The Enzymology of Coupling Electron Transfer Reactions to Transmembrane Proton Translocation

    Bernard L. Trumpower;Robert B. Gennis

  • Specific roles of protein-phospholipid interactions in the yeast cytochrome bc1 complex structure.

    Christian Lange;Juergen H. Nett;Bernard L. Trumpower;Carola Hunte

  • The Protonmotive Q Cycle in Mitochondria and Bacteria

    Ulrich Brandt;Bernard Trumpower

  • Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p.

    Olivier Gadal;Daniela Strauß;Jacques Kessl;Bernard Trumpower

  • Isolation of ubiquinol oxidase from Paracoccus denitrificans and resolution into cytochrome bc1 and cytochrome c-aa3 complexes.

    E A Berry;B L Trumpower

  • Function of the iron-sulfur protein of the cytochrome b-c1 segment in electron-transfer and energy-conserving reactions of the mitochondrial respiratory chain

    Bernard L. Trumpower

  • Protonmotive pathways and mechanisms in the cytochrome bc1 complex

    Carola Hunte;Hildur Palsdottir;Bernard L Trumpower

  • New concepts on the role of ubiquinone in the mitochondrial respiratory chain

    Bernard L. Trumpower

  • Structure of the yeast cytochrome bc1 complex with a hydroxyquinone anion Qo site inhibitor bound

    Hildur Palsdottir;Carlos Gomez Lojero;Bernard L. Trumpower;Carola Hunte

  • Alteration of the Midpoint Potential and Catalytic Activity of the Rieske Iron-Sulfur Protein by Changes of Amino Acids Forming Hydrogen Bonds to the Iron-Sulfur Cluster

    Elke Denke;Torsten Merbitz-Zahradnik;Oliver M. Hatzfeld;Christopher H. Snyder

  • Superoxide anion generation by the cytochrome bc1 complex.

    Jian Sun;Bernard L Trumpower

  • Cytochrome bc1 complexes of microorganisms.

    Unknown

  • Purification of highly active cytochrome bc1 complexes from phylogenetically diverse species by a single chromatographic procedure

    Per O. Ljungdahl;Jeffrey D. Pennoyer;Dan E. Robertson;Bernard L. Trumpower

  • Molecular basis for atovaquone binding to the cytochrome bc1 complex.

    Jacques J. Kessl;Benjamin B. Lange;Torsten Merbitz-Zahradnik;Klaus Zwicker

  • Purification of a three-subunit ubiquinol-cytochrome c oxidoreductase complex from Paracoccus denitrificans.

    X H Yang;B L Trumpower

  • Energy transduction by cytochrome complexes in mitochondrial and bacterial respiration: the enzymology of coupling electron transfer reactions to transmembrane proton translocation.

    Unknown

  • An inhibitor of mitochondrial respiration which binds to cytochrome b and displaces quinone from the iron-sulfur protein of the cytochrome bc1 complex.

    G von Jagow;P O Ljungdahl;P Graf;T Ohnishi

  • The mitochondrial targeting presequence of the Rieske iron-sulfur protein is processed in a single step after insertion into the cytochrome bc1 complex in mammals and retained as a subunit in the complex.

    U. Brandt;L. Yu;Chang-An Yu;B. L. Trumpower

  • Qsr1p, a 60S ribosomal subunit protein, is required for joining of 40S and 60S subunits.

    Dominic P. Eisinger;Frederick A. Dick;Bernard L. Trumpower

  • An analogue of ubiquinone which inhibits respiration by binding to the iron-sulfur protein of the cytochrome b-c1 segment of the mitochondrial respiratory chain.

    J R Bowyer;C A Edwards;T Ohnishi;B L Trumpower

  • Cytochrome bc1 complexes of microorganisms

    Unknown

Frequent Co-Authors

Steven R. Meshnick
Steven R. Meshnick University of North Carolina at Chapel Hill
John D. Phillips
John D. Phillips University of Utah
Ulrich Brandt
Ulrich Brandt Radboud University
Tomoko Ohnishi
Tomoko Ohnishi University of Pennsylvania
Bernd Ludwig
Bernd Ludwig Goethe University Frankfurt
Gordon W. Gribble
Gordon W. Gribble Dartmouth College
Linda Yu
Linda Yu Oklahoma State University
Michael K. Bowman
Michael K. Bowman University of Alabama
Ole Wichmann
Ole Wichmann Robert Koch Institute
Thomas D. Fox
Thomas D. Fox Cornell University

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