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Bioorganic and Medicinal Chemistry Letters
H-index 31

Bioorganic and Medicinal Chemistry Letters

Ranking & Metrics

Discipline name Position Best Scientists Publications D-Index
Chemistry 270 315 426 27
Biology and Biochemistry 317 224 288 19

Additional Metrics

Number of Best Scientists*: 678
Documents by Best Scientists*: 727
Top 100 Ranked Scientists*: 20
SCIMAGO H-index: 172
SCIMAGO SJR: 0.472
Impact Factor: 2.2

Overview

Top Research Topics at Bioorganic & Medicinal Chemistry Letters?

The journal primarily focuses on research topics in Stereochemistry, Biochemistry, Chemical synthesis, In vitro and Structure–activity relationship. The journal explores issues in Stereochemistry which can be linked to other research areas like Biological activity, Receptor and Enzyme inhibitor, Enzyme. The majority of Receptor studies presented zero in on Agonist.

It connects research in Enzyme inhibitor with the related topic of Molecular model. The journal focuses on Biochemistry research which is adjacent to topics in Cell culture. The research on Chemical synthesis tackled can also make contributions to studies in the areas of Antibacterial agent, Antagonist and Bicyclic molecule, Organic chemistry, Carboxamide.

The journal dives deep in exploring the relationship between the study of In vitro and In vivo. It connects the study in In vivo with the closely related area of Pharmacology.

  • Stereochemistry (57.11%)
  • Biochemistry (30.01%)
  • Chemical synthesis (28.08%)

What are the most cited papers published in the journal?

  • Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids (608 citations)
  • Physiochemical drug properties associated with in vivo toxicological outcomes (558 citations)
  • Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction (528 citations)

Research areas of the most cited articles at Bioorganic & Medicinal Chemistry Letters:

The most cited publications primarily focus on research topics in Stereochemistry, Chemical synthesis, Biochemistry, Enzyme inhibitor and Enzyme. While work presented in the published articles provide substantial information on Stereochemistry, it also covers topics in Biological activity, Structure–activity relationship and Cytotoxicity. In addition to Biochemistry research, the journal articles aim to explore topics under Cell culture and Pharmacology.

What topics the last edition of the journal is best known for?

  • Enzyme
  • Organic chemistry
  • Biochemistry

The previous edition focused in particular on these issues:

The main points discussed in the journal deals with Stereochemistry, Biochemistry, Pharmacology, In vitro and Combinatorial chemistry. Most of the Stereochemistry studies addressed also intersect with Structure–activity relationship. Enzyme and IC50 are all subfields of Biochemistry research that were featured in the journal.

The Pharmacology research presented in the journal explores the relationship between Cytotoxicity and the closely related topic of Cancer cell, Apoptosis, Cell culture and Cancer research. It investigates In vitro research which frequently intersects with In vivo. Research on Combinatorial chemistry addressed in Bioorganic & Medicinal Chemistry Letters frequently intersections with the field of Antimicrobial.

The most cited articles from the last journal are:

  • 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. (9 citations)
  • Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. (8 citations)
  • Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2. (7 citations)

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

The top authors publishing in Bioorganic & Medicinal Chemistry Letters (based on the number of publications) are:

  • Claudiu T. Supuran (232 papers) published 5 papers at the last edition,
  • Andrea Scozzafava (154 papers) absent at the last edition,
  • Craig W. Lindsley (126 papers) published 4 papers at the last edition, 1 less than at the previous edition,
  • William J. Greenlee (95 papers) absent at the last edition,
  • Kuo Hsiung Lee (93 papers) published 1 paper at the last edition the same number as at the previous edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Only papers with recognized affiliations are considered

The top affiliations publishing in Bioorganic & Medicinal Chemistry Letters (based on the number of publications) are:

  • Merck & Co. (1128 papers) published 7 papers at the last edition, 7 less than at the previous edition,
  • Bristol-Myers Squibb (651 papers) published 8 papers at the last edition, 8 less than at the previous edition,
  • Pfizer (631 papers) published 2 papers at the last edition, 1 more than at the previous edition,
  • Chinese Academy of Sciences (483 papers) published 14 papers at the last edition, 8 less than at the previous edition,
  • GlaxoSmithKline (390 papers) published 3 papers at the last edition, 2 less than at the previous edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 6.18% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 8.78% were posted by at least one author from the top 10 institutions publishing in the journal. Another 5.39% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 14.37% of all publications and 71.46% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

  • Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
  • Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
  • Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
  • Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
  • Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Involvement of Academic Institutions in High-Impact Research

One missing section that could enhance the depth of this article involves the role of academic institutions in publishing high-impact research within this journal. Specifically, there could be a focus on major universities and colleges that have made significant contributions to the publications in the realm of Bioorganic and Medicinal Chemistry Letters. In this section, we aim to highlight institutions that have consistently produced high-quality research in the topics covered by this journal. This includes Stereochemistry, Biochemistry, Chemical synthesis, Enzyme inhibitor, and Enzyme studies. Recognizing these institutions supports visibility and acknowledgment of emerging research trends and significant academic achievements. Some educational institutions offer programs dedicated to educating Medical Assistants, who play a vital role in the field of biological and medicinal chemistry research. For instance, you can consider undergoing medical assistant training in West Virginia, which provides a solid foundation in the principles discussed in this journal. In the future, we plan to incorporate more detailed statistics about these institutions and their contributions to the key topics featured in Bioorganic and Medicinal Chemistry Letters. This data can provide a new lens to appreciate the diverse academic involvement in the realm of bioorganic and medicinal chemistry research.

Top Publications

  • Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir

    (2021)
    309 Citations
  • Structural hybridization as a facile approach to new drug candidates.

    Halmuthur M. Sampath Kumar;Lars Herrmann;Svetlana B. Tsogoeva

    (2020)
    151 Citations
  • 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies.

    Ramesh Gondru;Sirisha Kanugala;Sneha Raj;C Ganesh Kumar

    (2021)
    87 Citations
  • Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties.

    Saul Jaime-Figueroa;Alexandru D. Buhimschi;Momar Toure;John Hines

    (2020)
    76 Citations
  • A First-in-Class Clinical G-Quadruplex-Targeting Drug. The Bench-to-Bedside Translation of the Fluoroquinolone QQ58 to CX-5461 (Pidnarulex).

    (2022)
    69 Citations
  • From coins to cancer therapy: Gold, silver and copper complexes targeting human topoisomerases

    Jessica Ceramella;Annaluisa Mariconda;Domenico Iacopetta;Carmela Saturnino

    (2020)
    58 Citations
  • Cryo-EM as a powerful tool for drug discovery.

    John H Van Drie;Liang Tong

    (2020)
    58 Citations
  • Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles.

    Yan-Fei Sui;Di Li;Juan Wang;Rammohan R. Yadav Bheemanaboina

    (2020)
    50 Citations

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