ACS Medicinal Chemistry Letters

Top Research Topics at ACS Medicinal Chemistry Letters?

ACS Medicinal Chemistry Letters is mainly concerned with subjects like Pharmacology, Stereochemistry, Biochemistry, In vivo and In vitro. The journal holds forums on Pharmacology that merges themes from other disciplines such as Agonist, Receptor and Potency. ACS Medicinal Chemistry Letters focuses on Stereochemistry but the discussions also offer insight into other areas such as Combinatorial chemistry, Selectivity and IC50.

Enzyme, Small molecule and Kinase are among the areas of Biochemistry tackled. Studies on In vivo discussed in ACS Medicinal Chemistry Letters link to the field of Cancer research.

• Pharmacology (24.67%)
• Stereochemistry (18.47%)
• Biochemistry (18.09%)

What are the most cited papers published in the journal?

• Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. (281 citations)
• Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin (264 citations)
• Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist (233 citations)

Research areas of the most cited articles at ACS Medicinal Chemistry Letters:

The most cited papers mainly deal with areas of study such as Pharmacology, Biochemistry, In vivo, Stereochemistry and Combinatorial chemistry. Issues in Pharmacology were discussed in the most cited articles, taking into consideration concepts from other disciplines like In vitro, Potency, Kinase and Small molecule. While Stereochemistry is the focus of the published papers, it also provides insights into the studies of IC50 and Selectivity.

What topics the last edition of the journal is best known for?

• Enzyme
• Gene
• Internal medicine

The previous edition focused in particular on these issues:

The primary areas of discussion in ACS Medicinal Chemistry Letters are Cancer research, Biochemistry, Pharmacology, In vitro and Cancer. Cancer research research featured in it incorporates concerns from various other topics such as Text mining, KRAS, Mutant and Kinase. Biochemistry studies presented in it focus on topics such as Peptide, Enzyme and Small molecule.

Pharmacokinetics is a primary topic of Pharmacology research in it. In vitro study tackled is connected to the field of In vivo. The studies on In vivo discussed can also contribute to research in the domains of Potency and Bioavailability.

The most cited articles from the last journal are:

• Solution Conformations Shed Light on PROTAC Cell Permeability. (14 citations)
• Steering New Drug Discovery Campaigns: Permeability, Solubility, and Physicochemical Properties in the bRo5 Chemical Space. (7 citations)
• Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain (6 citations)

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

Top authors and change over time

The top authors publishing in ACS Medicinal Chemistry Letters (based on the number of publications) are:

• Ahmed F. Abdel-Magid (148 papers) published 6 papers at the last edition, 1 more than at the previous edition,
• Robert B. Kargbo (84 papers) published 28 papers at the last edition, 7 more than at the previous edition,
• Ram W. Sabnis (77 papers) published 61 papers at the last edition, 45 more than at the previous edition,
• Benjamin E. Blass (53 papers) published 1 paper at the last edition, 2 less than at the previous edition,
• Gerard Rosse (46 papers) absent at the last edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Top affiliations and change over time

Only papers with recognized affiliations are considered

The top affiliations publishing in ACS Medicinal Chemistry Letters (based on the number of publications) are:

• Merck & Co. (109 papers) published 12 papers at the last edition, 3 more than at the previous edition,
• Bristol-Myers Squibb (72 papers) published 10 papers at the last edition the same number as at the previous edition,
• GlaxoSmithKline (68 papers) published 5 papers at the last edition, 1 more than at the previous edition,
• Temple University (65 papers) published 2 papers at the last edition, 6 less than at the previous edition,
• Novartis (56 papers) absent at the last edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 36.13% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 22.22% were posted by at least one author from the top 10 institutions publishing in the journal. Another 8.59% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 11.62% of all publications and 57.58% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

• Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
• Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
• Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
• Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
• Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Career Prospects in the Field of Medicinal Chemistry

There remains an increasing demand for specialists in the field of medicinal chemistry. This is because the complex and evolving nature of diseases necessitates continuous research for effective treatments. This article has highlighted the popular research topics at ACS Medicinal Chemistry Letters, which include Pharmacology, Stereochemistry, and Biochemistry among others. These can be very insightful areas to those already practicing or intending to venture into careers as Medicinal Chemists. If you're considering a career in this field, it's of interest to note that apart from being research scientists or educators, medicinal chemists also find opportunities in pharmaceutical industries as drug developers. Additionally, you may also consider specializing in other closely related fields. For instance, a career in medical billing and coding could be an exciting prospect worth exploring. This involves more direct interactions with healthcare providers and could give you a more comprehensive understanding of the healthcare system, putting you in an advantaged position as a medicinal chemist. For more details on how to start a career in medical billing and coding in Kentucky, check out the informative guide how to be a medical coder in Kentucky, which offers a step-by-step guide on how to become successful in this field. Remember, diversification of skills can make you more competitive and increase your career prospects in the expansive field of medicinal chemistry. No matter which career path you choose in this field, gaining a deeper understanding of the popular research topics at ACS Medicinal Chemistry Letters will undoubtedly serve you well.