World's Best Scientists 2026 revealed!
Toshimasa Toyo'oka

Toshimasa Toyo'oka

D-Index & Metrics

Chemistry

D-Index
63
Citations
11187
World Ranking
8632
National Ranking
584

Overview

Toshimasa Toyo'oka is affiliated with the University of Shizuoka in Japan and has focused their research primarily within the field of Biochemistry, Genetics and Molecular Biology. Their work covers a range of subfields including Molecular Biology, Spectroscopy, Biomedical Engineering, Radiology, Nuclear Medicine and Imaging, and Clinical Biochemistry.

The central themes of Toyo'oka's research involve advanced biosensing and bioanalysis techniques, monoclonal and polyclonal antibodies research, mass spectrometry techniques and applications, metabolomics and mass spectrometry studies, analytical chemistry and chromatography, RNA interference and gene delivery, as well as innovative microfluidic and catalytic techniques innovation.

They have published numerous papers, some of which include:

  • Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection (2022, Biosensors and Bioelectronics)
  • Rapid chiral discrimination of oncometabolite dl-2-hydroxyglutaric acid using derivatization and field asymmetric waveform ion mobility spectrometry/mass spectrometry (2021, Journal of Separation Science)
  • Machine learning guided prediction of liquid chromatography-mass spectrometry ionization efficiency for genotoxic impurities in pharmaceutical products (2020, Journal of Pharmaceutical and Biomedical Analysis)
  • Development of a selective and sensitive analytical method to detect isomerized aspartic acid residues in crystallin using a combination of derivatization and liquid chromatography mass spectrometry (2020, Journal of Chromatography A)
  • Efficient screening of anti-idiotype DNA aptamers that bind specifically to trastuzumab for bioanalytical applications (2023, Journal of Pharmaceutical and Biomedical Analysis Open)

Toyo'oka has frequently published in venues such as Chromatography, Biosensors and Bioelectronics, Journal of Separation Science, Journal of Pharmaceutical and Biomedical Analysis, and Journal of Chromatography A.

The scientist has collaborated repeatedly with several co-authors, including:

  • Hajime Mizuno
  • Kenichiro Todoroki
  • Eiji Sugiyama
  • Hideki Hayashi
  • Kaori Tsukakoshi

Best Publications

  • Creation of an On-Chip Enzyme Reactor by Encapsulating Trypsin in Sol−Gel on a Plastic Microchip

    Kumiko Sakai-Kato;Masaru Kato;Toshimasa Toyo'oka

  • A Protein-Encapsulation Technique by the Sol−Gel Method for the Preparation of Monolithic Columns for Capillary Electrochromatography

    Masaru Kato;Kumiko Sakai-Kato;Nozomi Matsumoto;Toshimasa Toyo'oka

  • Recent advances in separation and detection methods for thiol compounds in biological samples.

    Toshimasa Toyo’oka

  • A novel fluorogenic reagent for thiols : ammonium 7-fluorobenzo-2-oxa-1, 3-diazole-4-sulfonate

    Kazuhiro Imai;Toshimasa Toyo'oka;Yoshihiko Watanabe

  • High-performance liquid chromatography and fluorometric detection of biologically important thiols, derivatized with ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate (SBD-F)

    Toshimasa Toyo'oka;Kazuhiro Imai

  • On-line trypsin-encapsulated enzyme reactor by the sol-gel method integrated into capillary electrophoresis.

    Kumiko Sakai-Kato;and Masaru Kato;Toshimasa Toyo'oka

  • New fluorogenic reagent having halogenobenzofurazan structure for thiols: 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole

    Toshimasa. Toyooka;Kazuhiro. Imai

  • Integration of on-line protein digestion, peptide separation, and protein identification using pepsin-coated photopolymerized sol-gel columns and capillary electrophoresis/mass spectrometry.

    Masaru Kato;† Kumiko Sakai-Kato;HongMei Jin;Kazuyuki Kubota

  • Simple and practical derivatization procedure for enhanced detection of carboxylic acids in liquid chromatography-electrospray ionization-tandem mass spectrometry.

    Tatsuya Higashi;Takuya Ichikawa;Shinsuke Inagaki;Jun Zhe Min

  • Fluorigenic reagents for primary and secondary amines and thiols in high-performance liquid chromatography. A review

    Kazuhiro Imai;Toshimasa Toyo'oka;Hiroshi Miyano

  • Silica sol‐gel monolithic materials and their use in a variety of applications

    Masaru Kato;Kumiko Sakai-Kato;Toshimasa Toyo'oka

  • Precolumn fluorescence tagging reagent for carboxylic acids in high-performance liquid chromatography: 4-substituted-7-aminoalkylamino-2,1,3-benzoxadiazoles.

    Toshimasa Toyo'oka;Mumio Ishibashi;Yasushi Takeda;Kenichiro Nakashima

  • Resolution of chiral drugs by liquid chromatography based upon diastereomer formation with chiral derivatization reagents.

    Toshimasa Toyo'oka

  • Simultaneous determination of D- and L-serine in rat brain microdialysis sample using a column-switching HPLC with fluorimetric detection.

    Takeshi Fukushima;Takeshi Fukushima;Junko Kawai;Kazuhiro Imai;Kazuhiro Imai;Toshimasa Toyo'oka

  • Advances in determination of vitamin D related compounds in biological samples using liquid chromatography-mass spectrometry: a review.

    Tatsuya Higashi;Kazutake Shimada;Toshimasa Toyo’oka

  • Monolithic bioreactor immobilizing trypsin for high-throughput analysis.

    Masaru Kato;Kenji Inuzuka;Kumiko Sakai-Kato;Toshimasa Toyo'oka

  • Further studies on the reaction of amines and proteins with 4-fluoro-7-nitrobenzo-2-oxa-1,3-diazole

    Hiroshi Miyano;Toshimasa Toyo'oka;Kazuhiro Imai

  • Fluorogenic reagent for thiols: 4-(N,N-dimethylaminosulphonyl)-7-fluoro-2,1,3-benzoxadiazole.

    Toshimasa Toyo′oka;Takashi Suzuki;Yukio Saito;Sonoko Uzu

  • Fluorescent tagging of physiologically important carboxylic acids, including fatty acids, for their detection in liquid chromatography

    Toshimasa Toyo’oka

  • Isolation and characterization of cysteine-containing regions of proteins using 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole and high-performance liquid chromatography.

    Toshimasa. Toyo'oka;Kazuhiro. Imai

Frequent Co-Authors

Kazuhiro Imai
Kazuhiro Imai University of Tokyo
Noriyuki Matsukawa
Noriyuki Matsukawa Nagoya City University
Yukihiro Goda
Yukihiro Goda Ministry of Health Labour and Welfare
Kenji Hashimoto
Kenji Hashimoto Chiba University
Richard N. Zare
Richard N. Zare Stanford University
Makoto Michikawa
Makoto Michikawa Nagoya City University
Naoki Miyata
Naoki Miyata Nagoya City University
Kazunori Ikebukuro
Kazunori Ikebukuro Tokyo University of Agriculture and Technology
Ikuo Tooyama
Ikuo Tooyama Shiga University of Medical Science
Yong-Ill Lee
Yong-Ill Lee Changwon National University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Chemistry through online degrees opens diverse career opportunities beyond traditional lab roles. Students often pursue specialized fields such as pharmaceutical sales, where understanding chemical compounds and drug formulations is critical. To learn more about entering this field, check out how to get into pharmaceutical sales.

For those drawn to healthcare and medication management, becoming a pharmacist is a rewarding path. This career demands rigorous education and licensing but offers excellent growth and earning potential. Understanding how do you become a pharmacist can guide your academic planning and professional development.

Chemistry graduates can also specialize in forensic science by working as a forensic autopsy technician. This role integrates chemistry knowledge with investigative techniques to assist in legal cases. Resources on forensic autopsy technician education, salary, and job outlook provide valuable insights for career planning.

Additionally, there are alternative yet adjacent fields, such as paralegal services, which may appeal to those interested in the legal aspects of chemicals and patents. Research into what types of paralegals make the most money can help identify lucrative niches and inform decisions about further education.

Best Scientists Citing Toshimasa Toyo'oka

Trending Scientists