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Biology and Biochemistry

D-Index
64
Citations
13642
World Ranking
9744
National Ranking
301

Overview

Takashi Ikejima is affiliated with Shenyang Pharmaceutical University in China. Their research spans primarily the fields of Biochemistry, Genetics and Molecular Biology, with a substantial focus also on Medicine. Subfields of study include Molecular Biology, Pulmonary and Respiratory Medicine, Immunology, Cell Biology, and Physiology.

Their main research topics cover a variety of biological and biochemical mechanisms, specifically:

  • Silymarin and Mushroom Poisoning
  • Interferon and Immune Responses
  • Autophagy in Disease and Therapy
  • Heme Oxygenase-1 and Carbon Monoxide
  • Hippo pathway signaling and YAP/TAZ
  • Inflammasome and Immune Disorders
  • Calcium signaling and nucleotide metabolism

Takashi Ikejima has contributed to numerous research publications. Among the recent papers are:

  • "DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells" (2021, Molecular Immunology)
  • "Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation" (2021, Physiology & Behavior)
  • "Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines" (2022, Toxicology in Vitro)
  • "Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy" (2023, Archives of Biochemistry and Biophysics)
  • "Silibinin-induced mitochondria fission leads to mitophagy, which attenuates silibinin-induced apoptosis in MCF-7 and MDA-MB-231 cells" (2020, Archives of Biochemistry and Biophysics)

Frequent publication venues for Ikejima's work include:

  • Archives of Biochemistry and Biophysics
  • Molecular Immunology
  • Toxicology in Vitro
  • Connective Tissue Research
  • Cellular Signalling

Their collaborative work features co-authorship with several researchers, notably:

  • Shunji Hattori
  • Hitomi Fujisaki
  • Kazunori Mizuno
  • Toshihiko Hayashi
  • Weiwei Liu

Best Publications

  • Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

    S Okusawa;J A Gelfand;T Ikejima;R J Connolly

  • Interleukin 1 induces interleukin 1. I: Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro

    C. A. Dinarello;T. Ikejima;S. J. C. Warner;S. F. Orencole

  • Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice

    P. Lu;P. Lu;T. Mamiya;L. L. Lu;L. L. Lu;Akihiro Mouri

  • Concentrations of immunoreactive human tumor necrosis factor alpha produced by human mononuclear cells in vitro

    J. W.M. Van Der Meer;S. Endres;G. Lonnemann;Joseph Gerard Cannon

  • Induction of human interleukin-1 by a product of Staphylococcus aureus associated with toxic shock syndrome.

    T Ikejima;C A Dinarello;D M Gill;S M Wolff

  • Interleukin-1 induces tumor necrosis factor (TNF) in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits.

    T. Ikejima;S. Okusawa;P. Ghezzi;J.W.M. van der Meer

  • ERK and JNK mediate TNFα-induced p53 activation in apoptotic and autophagic L929 cell death

    Yan Cheng;Feng Qiu;Shin-ichi Tashiro;Satoshi Onodera

  • Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells.

    Qiao Cui;Shin-ichi Tashiro;Satoshi Onodera;Mutsuhiko Minami

  • Molecular Characterization and Diagnostic Value of Taenia solium Low-Molecular-Weight Antigen Genes

    Yasuhito Sako;Minoru Nakao;Takashi Ikejima;Xian Zhi Piao

  • Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways

    Ning Kang;Jing-Hai Zhang;Feng Qiu;Shin-ichi Tashiro

  • Reactive Oxygen Species Mediate Oridonin-Induced HepG2 Apoptosis Through p53, MAPK, and Mitochondrial Signaling Pathways

    Jian Huang;Lijun Wu;Shin-ichi Tashiro;Satoshi Onodera

  • Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells.

    Xiao Fang Fei;Ben Xiang Wang;Tei Jin Li;Shin-ichi Tashiro

  • p53-Mediated Cell Cycle Arrest and Apoptosis Induced by Shikonin via a Caspase-9-Dependent Mechanism in Human Malignant Melanoma A375-S2 Cells

    Zhen Wu;Lijun Wu;Linhao Li;Shin-ichi Tashiro

  • Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation.

    Qiao Cui;Shin-ichi Tashiro;Satoshi Onodera;Mutsuhiko Minami

  • P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells.

    Qiao Cui;Jing-hua Yu;Jin-nan Wu;Shin-ichi Tashiro

  • Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells.

    Jia Yang;Li-Jun Wu;Shin-Ichi Tashino;Satoshi Onodera

  • Autophagy inhibits reactive oxygen species‐mediated apoptosis via activating p38‐nuclear factor‐kappa B survival pathways in oridonin‐treated murine fibrosarcoma L929 cells

    Yan Cheng;Feng Qiu;Yuan-Chao Ye;Zhao-Ming Guo

  • Crystallization behavior and environmental biodegradability of the blend films of poly(3-hydroxybutyric acid) with chitin and chitosan

    T Ikejima;Y Inoue

  • Induction by Toxic-Shock-Syndrome Toxin-1 of a Circulating Tumor Necrosis Factor-Like Substance in Rabbits and of Immunoreactive Tumor Necrosis Factor and Interleukin-1 from Human Mononuclear Cells

    T. Ikejima;S. Okusawa;J.W.M. van der Meer;C.A. Dinarello

  • Silibinin Protects Against Isoproterenol-Induced Rat Cardiac Myocyte Injury Through Mitochondrial Pathway After Up-regulation of SIRT1

    Bei Zhou;Li-Jun Wu;Lin-Hao Li;Shin-ichi Tashiro

Frequent Co-Authors

Satoshi Onodera
Satoshi Onodera Showa Pharmaceutical University
Shin-ichi Tashiro
Shin-ichi Tashiro Kyoto Prefectural University of Medicine
Charles A. Dinarello
Charles A. Dinarello University of Colorado Anschutz Medical Campus
Masayuki Yamato
Masayuki Yamato Tokyo Women's Medical University
Akira Ito
Akira Ito Asahikawa Medical University
Minoru Nakao
Minoru Nakao Asahikawa Medical University
Toshitaka Nabeshima
Toshitaka Nabeshima Meijo University
Haruki Yamada
Haruki Yamada Kitasato University
Taku Nagai
Taku Nagai Nagoya University
Marcello Otake Sato
Marcello Otake Sato Niigata University of Pharmacy and Applied Life Sciences

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