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D-Index & Metrics

Neuroscience

D-Index
34
Citations
6075
World Ranking
9287
National Ranking
3925

Overview

Stuart W. Hughes is affiliated with Vertex Pharmaceuticals in the United States. Their research spans multiple disciplines within medicine and biochemistry, genetics, and molecular biology, with a focus on molecular biology, physiology, immunology, oncology, and health informatics.

Hughes's main topics of study include receptor mechanisms and signaling, adenosine and purinergic signaling, drug transport and resistance mechanisms, artificial intelligence in healthcare and education, immune cells in cancer, inflammatory mediators and NSAID effects, and genetic and kidney cyst diseases.

The scientist has published extensively across several well-known venues. Frequent publication venues include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Regular and Young Investigator Award Abstracts
  • Journal of the American Society of Nephrology
  • Medical Science Educator

Recent publications reflect a diverse research scope. These include:

  • Detection of PKD1 and PKD2 Somatic Variants in Autosomal Dominant Polycystic Kidney Cyst Epithelial Cells by Whole-Genome Sequencing (2021, Journal of the American Society of Nephrology)
  • Can ChatGPT-4o Really Pass Medical Science Exams? A Pragmatic Analysis Using Novel Questions (2025, Medical Science Educator)
  • Abstract 2162: Inhibition of GPR65 counteracts low pH induced immunosuppressive polarization of macrophages: In vitro and in vivo characterization of potent, selective and orally bioavailable small molecule GPR65 antagonists (2022, Cancer Research)
  • Measurement and State-Dependent Modulation of Hypoglossal Motor Excitability and Responsivity In-Vivo (2020, Scientific Reports)
  • Can ChatGPT-4o really pass medical science exams? A pragmatic analysis using novel questions (2024, bioRxiv (Cold Spring Harbor Laboratory))

Hughes regularly collaborates with a group of frequent co-authors, who include:

  • Alan Naylor
  • Barbara Cipriani
  • Gavin Milne
  • David Miller
  • Barbara Young

Their work reflects significant contributions to understanding complex biological signaling pathways, immune responses in cancer, and the application of artificial intelligence in medical education and healthcare. This multidisciplinary approach demonstrates a broad engagement with both fundamental and applied biomedical research topics.

Best Publications

  • Thalamic Mechanisms of EEG Alpha Rhythms and Their Pathological Implications

    Stuart W. Hughes;Vincenzo Crunelli

  • The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators

    Vincenzo Crunelli;Stuart Wynn Hughes;Stuart Wynn Hughes

  • Are corticothalamic UP states fragments of wakefulness

    Alain Destexhe;Stuart W. Hughes;Michelle Rudolph;Vincenzo Crunelli

  • Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm

    Magor L. Lőrincz;Katalin A. Kékesi;Gábor Juhász;Vincenzo Crunelli

  • GABAA Receptor-Mediated Tonic Inhibition in Thalamic Neurons

    David W. Cope;Stuart W. Hughes;Vincenzo Crunelli

  • Synchronized Oscillations at α and θ Frequencies in the Lateral Geniculate Nucleus

    Stuart Wynn Hughes;Magor Lörincz;David William Cope;Kate L. Blethyn

  • Cellular mechanisms of the slow (<1 Hz) oscillation in thalamocortical neurons in vitro.

    Stuart Wynn Hughes;David W. Cope;Kate L. Blethyn;Vincenzo Crunelli

  • Identification of the Mechanism Mediating Genioglossus Muscle Suppression in REM Sleep

    Kevin P. Grace;Stuart W. Hughes;Richard L. Horner

  • The "window" component of the low threshold Ca2+ current produces input signal amplification and bistability in cat and rat thalamocortical neurones.

    Stephen R. Williams;Tibor I. Tóth;Jonathan P. Turner;Stuart W. Hughes

  • The 'window' T-type calcium current in brain dynamics of different behavioural states

    Vincenzo Crunelli;Tibor I. Tóth;David W. Cope;Kate Blethyn

  • The thalamocortical network as a single slow wave-generating unit.

    Vincenzo Crunelli;Francois David;Magor L Lőrincz;Stuart W Hughes

  • Thalamic T-type Ca2+ channels and NREM sleep

    Vincenzo Crunelli;David William Cope;Stuart Wynn Hughes

  • Cellular dynamics of cholinergically-induced alpha (8-13 Hz) rhythms in sensory thalamic nuclei in vitro

    Magor L Lörincz;Vincenzo Crunelli;Stuart W Hughes

  • All thalamocortical neurones possess a T-type Ca2+ 'window' current that enables the expression of bistability-mediated activities.

    Stuart W. Hughes;David W. Cope;Tibor I. Tóth;Stephen R. Williams

  • Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity.

    Vincenzo Crunelli;Vincenzo Crunelli;Magor L. Lőrincz;William M. Connelly;François David

  • Neuronal Basis of the Slow (<1 Hz) Oscillation in Neurons of the Nucleus Reticularis Thalami In Vitro

    Kate L. Blethyn;Stuart Wynn Hughes;Tibor Istvan Tóth;David W. Cope

  • ATP-Dependent Infra-Slow (<0.1 Hz) Oscillations in Thalamic Networks

    Magor L. Lőrincz;Freya Geall;Ying Bao;Vincenzo Crunelli

  • Infraslow (< 0.1 Hz) oscillations in thalamic relay nuclei: basic mechanisms and significance to health and disease states

    Stuart Wynn Hughes;Magor Lőrincz;H. Rheinhallt Parri;Vincenzo Crunelli

  • Just a phase they're going through: The complex interaction of intrinsic high-threshold bursting and gap junctions in the generation of thalamic α and θ rhythms

    Stuart W. Hughes;Vincenzo Crunelli

  • State-dependent and reflex drives to the upper airway: basic physiology with clinical implications.

    Richard L. Horner;Stuart W. Hughes;Atul Malhotra;Atul Malhotra

Frequent Co-Authors

Vincenzo Crunelli
Vincenzo Crunelli Cardiff University
Stephen R. Williams
Stephen R. Williams University of Queensland
Matt Jones
Matt Jones University of Bristol
Alain Destexhe
Alain Destexhe Centre national de la recherche scientifique, CNRS
John G. Parnavelas
John G. Parnavelas University College London
John T.R. Isaac
John T.R. Isaac Johnson & Johnson (United States)
Stéphane Charpier
Stéphane Charpier Sorbonne University
Jean-Michel Deniau
Jean-Michel Deniau Collège de France

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