World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
107
Citations
49374
World Ranking
578
National Ranking
290

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Genetics

His main research concerns Gene, Genetics, Nucleic acid sequence, Molecular biology and Haptoglobin. His Gene study frequently involves adjacent topics like DNA. Oliver Smithies interconnects Protein primary structure, Structural gene and Coding region in the investigation of issues within Nucleic acid sequence.

His Molecular biology research incorporates elements of Gene targeting, Germline and Homologous recombination. His work deals with themes such as Chromosome engineering and Chromosomal rearrangement, which intersect with Haptoglobin. His study in Globin is interdisciplinary in nature, drawing from both Plasmid, Non-homologous end joining, Non-allelic homologous recombination, FLP-FRT recombination and Locus.

His most cited work include:

  • The structure and evolution of the human β-globin gene family (964 citations)
  • Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. (854 citations)
  • Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes (706 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Genetics, Gene, Molecular biology, DNA and Biochemistry. His work is dedicated to discovering how Genetics, Haptoglobin are connected with Chromosome engineering and Chromosomal rearrangement and other disciplines. In general Gene study, his work on Globin, Peptide sequence, Gene duplication and Plasmid often relates to the realm of Direct repeat, thereby connecting several areas of interest.

He has included themes like Cell culture, Beta-2 microglobulin, Structural gene and Immunoglobulin heavy chain in his Molecular biology study. The study incorporates disciplines such as Homologous chromosome, Chromosome, Molecular cloning, In vitro recombination and A gamma-Globin in addition to DNA. His Biochemistry research is multidisciplinary, relying on both Layer and Polyvinylpyrrolidone.

He most often published in these fields:

  • Genetics (68.66%)
  • Gene (50.75%)
  • Molecular biology (32.84%)

What were the highlights of his more recent work (between 1982-2016)?

  • Genetics (68.66%)
  • Gene (50.75%)
  • Molecular biology (32.84%)

In recent papers he was focusing on the following fields of study:

Oliver Smithies mainly investigates Genetics, Gene, Molecular biology, Homologous recombination and Locus. His is involved in several facets of Genetics study, as is seen by his studies on Gene cluster, DNA, Homology, Allele and Nucleic acid sequence. His work on Globin, Plasmid, Base pair and DNA sequencing as part of general Gene study is frequently linked to Apolipoprotein B, therefore connecting diverse disciplines of science.

His research integrates issues of Cell culture, Beta-2 microglobulin, Embryonic stem cell and Somatic cell in his study of Molecular biology. His research in Homologous recombination intersects with topics in FLP-FRT recombination and Germline. In his work, Gene targeting is strongly intertwined with Mutant, which is a subfield of Germline.

Between 1982 and 2016, his most popular works were:

  • Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. (854 citations)
  • Targetted correction of a mutant HPRT gene in mouse embryonic stem cells (687 citations)
  • Duplication within the haptoglobin Hp2 gene. (176 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Genetics

Oliver Smithies mostly deals with Gene, Genetics, DNA sequencing, Gene targeting and Globin. His study ties his expertise on Haptoglobin together with the subject of Genetics. His DNA sequencing research includes themes of Gene duplication, Restriction map, Allele and Intron.

His Gene targeting research is multidisciplinary, incorporating elements of Gene cluster, Concerted evolution and Gene family. His Globin research includes elements of Gene rearrangement, Hereditary persistence of fetal hemoglobin, DNA, Breakpoint and Locus. His studies in Locus integrate themes in fields like Molecular biology and Homologous recombination.

Best Publications

  • A comprehensive set of sequence analysis programs for the VAX

    John Devereux;Paul Haeberli;Oliver Smithies

  • The structure and evolution of the human β-globin gene family

    Argiris Efstratiadis;James W. Posakony;Tom Maniatis;Richard M. Lawn

  • Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination.

    Oliver Smithies;Ronald G. Gregg;Sallie S. Boggs;Michael A. Koralewski

  • Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes

    Jerry L. Slightom;Ann E. Blechl;Oliver Smithies

  • Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

    Thomas Doetschman;Ronald G. Gregg;Nobuyo Maeda;Martin L. Hooper

  • Charon phages: safer derivatives of bacteriophage lambda for DNA cloning

    Frederick R. Blattner;Bill G. Williams;Ann E. Blechl;Katherine Denniston-Thompson

  • Quantitative procedures for use with the Edman-Begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac.

    O. Smithies;D. Gibson;D. Gibson;E. M. Fanning;R. M. Goodfliesh

  • Male–female differences in fertility and blood pressure in ACE-deficient mice

    J. H. Krege;S. W. M. John;L. L. Langenbach;J. B. Hodgin

  • A Simple Hemagglutination System Requiring Small Amounts of Red Cells and Antibodies

    Thomas G. Wegmann;Oliver Smithies

  • Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses

    Randy J. Thresher;Martha Hotz Vitaterna;Yasuhide Miyamoto;Aleksey Kazantsev

  • The Structure and Evolution of the Human /?-Globin Gene Family

    Argiris Efstratiadis;James W. Posakony;Tom Maniatis;Richard M. Lawn

  • A history of the human fetal globin gene duplication.

    Shi hsiang Shen;Jerry L. Slightom;Oliver Smithies

  • Cloning human fetal γ globin and mouse α-type globin DNA: Preparation and screening of shotgun collections

    Frederick R. Blattner;Ann E. Blechl;Katherine Denniston-Thompson;Harvey E. Faber

  • Chromosomal rearrangements and the evolution of haptoglobin genes.

    Oliver Smithies;Oliver Smithies;G. E. Connell;G. E. Connell;G. H. Dixon;G. H. Dixon

  • Duplication within the haptoglobin Hp2 gene.

    Nobuyo Maeda;Funmei Yang;Don R. Barnett;Barbara H. Bowman

  • Initiation of protein synthesis at an unusual position in an immunoglobulin gene

    O. Smithies;M. D. Poulik

  • Unexpected relationships between four large deletions in the human β-globin gene cluster

    Elio F. Vanin;Paula S. Henthom;Dimitris Kioussis;Frank Grosveld

  • Inheritance of haptoglobin subtypes.

    Oliver Smithies;George E. Connell;Gordon H. Dixon

  • A mouse alpha-globin-related pseudogene lacking intervening sequences.

    Elio F. Vanin;Gregory I. Goldberg;Philip W. Tucker;Philip W. Tucker;Oliver Smithies

  • Genetic control of blood pressure and the angiotensinogen locus (essential hypertension/quantitative genetic trait/gene targeting/gene disruption/gene duplication)

    Hyung-Suk Kim;John H. Krege;Kimberly D. Kluckman;John R. Hagaman

Frequent Co-Authors

Jerry L. Slightom
Jerry L. Slightom AureoGen Biosciences (United States)
Raju Kucherlapati
Raju Kucherlapati Harvard University
Nobuyo Maeda
Nobuyo Maeda University of North Carolina at Chapel Hill
Frederick R. Blattner
Frederick R. Blattner University of Wisconsin–Madison
Philip W. Tucker
Philip W. Tucker The University of Texas at Austin
Titus H.J. Huisman
Titus H.J. Huisman Augusta University
James W. Posakony
James W. Posakony University of California, San Diego
Argiris Efstratiadis
Argiris Efstratiadis Biomedical Research Foundation of the Academy of Athens
Frank H. Ruddle
Frank H. Ruddle Yale University
Julia E. Richards
Julia E. Richards University of Michigan–Ann Arbor

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