What is he best known for?
The fields of study he is best known for:
His main research concerns Gene, Genetics, Nucleic acid sequence, Molecular biology and Haptoglobin.
His Gene study frequently involves adjacent topics like DNA.
Oliver Smithies interconnects Protein primary structure, Structural gene and Coding region in the investigation of issues within Nucleic acid sequence.
His Molecular biology research incorporates elements of Gene targeting, Germline and Homologous recombination.
His work deals with themes such as Chromosome engineering and Chromosomal rearrangement, which intersect with Haptoglobin.
His study in Globin is interdisciplinary in nature, drawing from both Plasmid, Non-homologous end joining, Non-allelic homologous recombination, FLP-FRT recombination and Locus.
His most cited work include:
- The structure and evolution of the human β-globin gene family (964 citations)
- Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. (854 citations)
- Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes (706 citations)
What are the main themes of his work throughout his whole career to date?
The scientist’s investigation covers issues in Genetics, Gene, Molecular biology, DNA and Biochemistry.
His work is dedicated to discovering how Genetics, Haptoglobin are connected with Chromosome engineering and Chromosomal rearrangement and other disciplines.
In general Gene study, his work on Globin, Peptide sequence, Gene duplication and Plasmid often relates to the realm of Direct repeat, thereby connecting several areas of interest.
He has included themes like Cell culture, Beta-2 microglobulin, Structural gene and Immunoglobulin heavy chain in his Molecular biology study.
The study incorporates disciplines such as Homologous chromosome, Chromosome, Molecular cloning, In vitro recombination and A gamma-Globin in addition to DNA.
His Biochemistry research is multidisciplinary, relying on both Layer and Polyvinylpyrrolidone.
He most often published in these fields:
- Genetics (68.66%)
- Gene (50.75%)
- Molecular biology (32.84%)
What were the highlights of his more recent work (between 1982-2016)?
- Genetics (68.66%)
- Gene (50.75%)
- Molecular biology (32.84%)
In recent papers he was focusing on the following fields of study:
Oliver Smithies mainly investigates Genetics, Gene, Molecular biology, Homologous recombination and Locus.
His is involved in several facets of Genetics study, as is seen by his studies on Gene cluster, DNA, Homology, Allele and Nucleic acid sequence.
His work on Globin, Plasmid, Base pair and DNA sequencing as part of general Gene study is frequently linked to Apolipoprotein B, therefore connecting diverse disciplines of science.
His research integrates issues of Cell culture, Beta-2 microglobulin, Embryonic stem cell and Somatic cell in his study of Molecular biology.
His research in Homologous recombination intersects with topics in FLP-FRT recombination and Germline.
In his work, Gene targeting is strongly intertwined with Mutant, which is a subfield of Germline.
Between 1982 and 2016, his most popular works were:
- Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. (854 citations)
- Targetted correction of a mutant HPRT gene in mouse embryonic stem cells (687 citations)
- Duplication within the haptoglobin Hp2 gene. (176 citations)
In his most recent research, the most cited papers focused on:
Oliver Smithies mostly deals with Gene, Genetics, DNA sequencing, Gene targeting and Globin.
His study ties his expertise on Haptoglobin together with the subject of Genetics.
His DNA sequencing research includes themes of Gene duplication, Restriction map, Allele and Intron.
His Gene targeting research is multidisciplinary, incorporating elements of Gene cluster, Concerted evolution and Gene family.
His Globin research includes elements of Gene rearrangement, Hereditary persistence of fetal hemoglobin, DNA, Breakpoint and Locus.
His studies in Locus integrate themes in fields like Molecular biology and Homologous recombination.
This overview was generated by a machine learning system which analysed the scientist’s
body of work. If you have any feedback, you can
contact us
here.
