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Chemistry

D-Index
44
Citations
5755
World Ranking
17006
National Ranking
694

Overview

Juan Luis Asensio is affiliated with the Spanish National Research Council in Spain. Their primary research interests lie in the fields of Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology, Organic Chemistry, and Biotechnology among other subfields.

Their recent work covers a range of topics including Glycosylation and Glycoproteins Research, Carbohydrate Chemistry and Synthesis, and Enzyme Production and Characterization. They have also contributed research on Advanced biosensing and bioanalysis techniques, Chemical Synthesis and Analysis, Biofuel production and bioconversion, as well as DNA and Nucleic Acid Chemistry.

Juan Luis Asensio has published papers in notable venues such as Chemistry - A European Journal, Surgery, Journal of the American Chemical Society, JACS Au, and Accounts of Chemical Research.

  • Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions (2021, Accounts of Chemical Research)
  • Dissecting the Essential Role of Anomeric β-Triflates in Glycosylation Reactions (2020, Journal of the American Chemical Society)
  • A glucotolerant β-glucosidase from the fungus Talaromyces amestolkiae and its conversion into a glycosynthase for glycosylation of phenolic compounds (2020, Microbial Cell Factories)
  • Thioglycoligase derived from fungal GH3 β-xylosidase is a multi-glycoligase with broad acceptor tolerance (2020, Nature Communications)
  • De Novo Design of Selective Quadruplex-Duplex Junction Ligands and Structural Characterisation of Their Binding Mode: Targeting the G4 Hot-Spot (2020, Chemistry - A European Journal)

Frequent coauthors in their research include Andrés G. Santana, Francisco Corzana, Laura Díaz-Casado, Jesús Jiménez-Barbero, and Laura Montalvillo-Jiménez. The collaboration with these researchers spans multiple projects and publications, highlighting interconnected efforts in their scientific fields.

Best Publications

  • Carbohydrate–Aromatic Interactions

    Juan Luis Asensio;Ana Ardá;Francisco Javier Cañada;Jesús Jiménez-Barbero

  • Structural basis for chitin recognition by defense proteins: GlcNAc residues are bound in a multivalent fashion by extended binding sites in hevein domains.

    Juan L Asensio;Francisco J Cañada;Hans-Christian Siebert;José Laynez

  • The contribution of cytosine protonation to the stability of parallel DNA triple helices.

    Juan Luis Asensio;Andrew N. Lane;Jaswant Dhesi;Simon Bergqvist

  • Experimental Evidence of Conformational Differences between C-Glycosides and O-Glycosides in Solution and in the Protein-Bound State: The C-Lactose/O-Lactose Case

    † Juan-Félix Espinosa;F. Javier Cañada;Juan Luis Asensio;† Manuel Martín-Pastor

  • Serine versus Threonine Glycosylation: The Methyl Group Causes a Drastic Alteration on the Carbohydrate Orientation and on the Surrounding Water Shell

    Francisco Corzana;Jesús H. Busto;Gonzalo Jiménez-Osés;Marisa García de Luis

  • The interaction of hevein with N-acetylglucosamine-containing oligosaccharides. Solution structure of hevein complexed to chitobiose.

    Juan Luis Asensio;Francisco Javier Canada;Marta Bruix;Adela Rodriguez-Romero

  • Free and protein-bound carbohydrate structures.

    Jesús Jiménez-Barbero;Juan Luis Asensio;Francisco Javier Cañada;Ana Poveda

  • The use of CVFF and CFF91 force fields in conformational analysis of carbohydrate molecules. Comparison with AMBER molecular mechanics and dynamics calculations for methyl α-lactoside

    Juan Luis Asensio;Manuel Martin-Pastor;Jesus Jimenez-Barbero

  • The use of the AMBER force field in conformational analysis of carbohydrate molecules: determination of the solution conformation of methyl alpha-lactoside by NMR spectroscopy, assisted by molecular mechanics and dynamics calculations.

    Juan Luis Asensio;Jesus Jimenez‐Barbero

  • The Interaction of Hevein with N‐acetylglucosamine‐containing Oligosaccharides

    Juan Luis Asensio;Francisco Javier Can̄ada;Marta Bruix;Adela Rodriguez-Romero

  • On the Importance of Carbohydrate–Aromatic Interactions for the Molecular Recognition of Oligosaccharides by Proteins: NMR Studies of the Structure and Binding Affinity of AcAMP2‐like Peptides with Non‐Natural Naphthyl and Fluoroaromatic Residues

    M. Isabel Chávez;M. Isabel Chávez;Cecilia Andreu;Paloma Vidal;Nuria Aboitiz

  • Conformational differences between O- and C-glycosides: the alpha-O-man-(1-->1)-beta-Gal/alpha-C-Man-(1-->1)-beta-Gal case--a decisive demonstration of the importance of the exo-anomeric effect on the conformation of glycosides.

    Juan L. Asensio;F. Javier Cañada;Xuhong Cheng;Noshena Khan

  • Conformational Selection of Glycomimetics at Enzyme Catalytic Sites: Experimental Demonstration of the Binding of Distinct High-Energy Distorted Conformations of C-, S-, and O-Glycosides by E. Coli β-Galactosidases

    Alicia García-Herrero;Esther Montero;Jose L Muñoz;Juan F Espinosa

  • Bovine Heart Galectin-1 Selects a Unique (Syn) Conformation of C-Lactose, a Flexible Lactose Analogue

    J. L. Asensio;J. F. Espinosa;H. Dietrich;F. J. Cañada

  • New Insights into α-GalNAc−Ser Motif: Influence of Hydrogen Bonding versus Solvent Interactions on the Preferred Conformation

    Francisco Corzana;Jesus H. Busto;Gonzalo Jimenez-Oses;Juan L. Asensio

  • Exploring the use of conformationally locked aminoglycosides as a new strategy to overcome bacterial resistance.

    Agatha Bastida;Ana Hidalgo;Jose Luis Chiara;Mario Torrado

  • NMR and Modeling Studies of Protein–Carbohydrate Interactions: Synthesis, Three‐Dimensional Structure, and Recognition Properties of a Minimum Hevein Domain with Binding Affinity for Chitooligosaccharides

    Nuria Aboitiz;Miquel Vila-Perelló;Patrick Groves;Juan Luis Asensio

  • Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody.

    Nuria Martínez‐Sáez;Nuria Martínez‐Sáez;Jorge Castro‐López;Jessika Valero‐González;David Madariaga

  • NMR investigations of protein-carbohydrate interactions: Studies on the relevance of Trp/Tyr variations in lectin binding sites as deduced from titration microcalorimetry and NMR studies on hevein domains. Determination of the NMR structure of the complex between pseudohevein and N,N ',N ''-triacetylchitotriose

    JL Asensio;HC Siebert;CW von der Lieth;J Laynez

  • Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions

    Antonio Franconetti;Ana Ardá;Juan Luis Asensio;Yves Blériot

  • The conformation of C-glycosyl compounds.

    Jesús Jiménez-Barbero;Juan Félix Espinosa;Juan Luis Asensio;Francisco Javier Cañada

Frequent Co-Authors

Carlos González
Carlos González Spanish National Research Council
F. Javier Cañada
F. Javier Cañada Spanish National Research Council
Gonçalo J. L. Bernardes
Gonçalo J. L. Bernardes University of Cambridge
Hans-Joachim Gabius
Hans-Joachim Gabius Ludwig-Maximilians-Universität München
María Jesús Martínez
María Jesús Martínez Spanish National Research Council
Marta Bruix
Marta Bruix Spanish National Research Council
Margarita Salas
Margarita Salas Spanish National Research Council

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