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Biology and Biochemistry

D-Index
79
Citations
45990
World Ranking
4193
National Ranking
316

Overview

Jonathan Tyrer is affiliated with the University of Cambridge in the United Kingdom. Their research spans multiple fields within biochemistry, genetics, molecular biology, and medicine. They have a particular focus on genetics, molecular biology, cancer research, reproductive medicine, and oncology.

The scientist's work addresses several main topics, including:

  • BRCA gene mutations in cancer
  • Genetic associations and epidemiology
  • Ovarian cancer diagnosis and treatment
  • Cancer-related molecular mechanisms research
  • RNA modifications and cancer
  • Genetic factors in colorectal cancer
  • Cancer genomics and diagnostics

Jonathan Tyrer has published extensively, with notable recent papers including:

  • "Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes" (2020) in Nature Genetics
  • "European polygenic risk score for prediction of breast cancer shows similar performance in Asian women" (2020) in Nature Communications
  • "Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer" (2020) in International Journal of Cancer
  • "Comprehensive epithelial tubo-ovarian cancer risk prediction model incorporating genetic and epidemiological risk factors" (2021) in Journal of Medical Genetics
  • "Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer" (2020) in Journal of Medical Genetics

Frequently publishing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, The American Journal of Human Genetics, Apollo (University of Cambridge), and Nature Genetics, Jonathan Tyrer maintains an active presence in prominent scientific forums.

Collaborative work forms a significant part of their research, with frequent co-authors including:

  • Paul D.P. Pharoah
  • Joe Dennis
  • Thilo Dörk
  • Douglas F. Easton
  • Simon A. Gayther

Best Publications

  • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

    Elizabeth K. Speliotes;Elizabeth K. Speliotes;Cristen J. Willer;Sonja I. Berndt;Keri L. Monda

  • Hundreds of variants clustered in genomic loci and biological pathways affect human height

    Hana Lango Allen;Karol Estrada;Guillaume Lettre;Sonja I. Berndt

  • Defining the role of common variation in the genomic and biological architecture of adult human height

    Andrew R. Wood;Tonu Esko;Jian Yang;Sailaja Vedantam

  • Genetic studies of body mass index yield new insights for obesity biology

    Adam E. Locke;Bratati Kahali;Sonja I. Berndt;Anne E. Justice

  • Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study.

    Gillian C. Barnett;Gillian C. Barnett;Charlotte E. Coles;Rebecca M. Elliott;Caroline Baynes

  • Association analysis identifies 65 new breast cancer risk loci

    Kyriaki Michailidou;Kyriaki Michailidou;Sara Lindström;Sara Lindström;Joe Dennis;Jonathan Beesley

  • A breast cancer prediction model incorporating familial and personal risk factors.

    Jonathan Tyrer;Stephen W. Duffy;Jack Cuzick

  • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

    E. K. Speliotes;C. J. Willer;S. I. Berndt;K. L. Monda

  • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

    Nasim Mavaddat;Kyriaki Michailidou;Kyriaki Michailidou;Joe Dennis;Michael Lush

  • Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

    Ganna Chornokur;Hui-Yi Lin;Jonathan P. Tyrer;Kate Lawrenson

  • Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

    Fredrick R. Schumacher;Ali Amin Al Olama;Sonja I. Berndt;Sara Benlloch

  • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

    Sonja I Berndt;Stefan Gustafsson;Stefan Gustafsson;Reedik Mägi;Reedik Mägi;Andrea Ganna

  • Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer

    Kelly L. Bolton;Kelly L. Bolton;Georgia Chenevix-Trench;Cindy Goh;Siegal Sadetzki

  • Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

    John R.B. Perry;Felix Day;Cathy E. Elks;Patrick Sulem

  • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

    Thomas W. Winkler;Anne E. Justice;Mariaelisa Graff;Llilda Barata

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

    Nasim Mavaddat;Paul D.P. Pharoah;Kyriaki Michailidou;Jonathan Tyrer

  • Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

    Felix R. Day;Deborah J. Thompson;Hannes Helgason;Hannes Helgason;Daniel I. Chasman

  • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

    Sonja I. Berndt;Stefan Gustafsson;Reedik Maegi;Andrea Ganna

  • Hundreds of variants clustered in genomic loci and biological pathways affect human height

    H. Lango Allen;K. Estrada;G. Lettre;S. I. Berndt

Frequent Co-Authors

Paul D.P. Pharoah
Paul D.P. Pharoah University of Cambridge
Graham G. Giles
Graham G. Giles University of Melbourne
Peter A. Fasching
Peter A. Fasching University of Erlangen-Nuremberg
Jenny Chang-Claude
Jenny Chang-Claude German Cancer Research Center
Susan J. Ramus
Susan J. Ramus University of New South Wales
Douglas F. Easton
Douglas F. Easton University of Cambridge
Ellen L. Goode
Ellen L. Goode Mayo Clinic
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute
Lambertus A. Kiemeney
Lambertus A. Kiemeney Radboud University

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