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Jeremy Peter Cheadle

Jeremy Peter Cheadle

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
18448
World Ranking
13566
National Ranking
1059

Overview

Jeremy Peter Cheadle is affiliated with Cardiff University in the United Kingdom. Their research primarily focuses on the genetics and molecular biology of colorectal cancer, with extensive work surrounding genetic factors, cancer genomics, and diagnostic approaches within oncology.

The main fields of study for Cheadle include Medicine and Biochemistry, Genetics and Molecular Biology. Their subfields of expertise encompass Pathology and Forensic Medicine, Genetics, Oncology, Cancer Research, and Molecular Biology.

The primary topics covered in their work are:

  • Genetic factors in colorectal cancer
  • Colorectal cancer treatments and studies
  • Genetic associations and epidemiology
  • Cancer genomics and diagnostics
  • Colorectal cancer screening and detection
  • Molecular biology techniques and applications
  • RNA modifications and cancer

Some of the recent papers authored or co-authored by Jeremy Peter Cheadle include:

  • Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries (2022, Nature Genetics)
  • Germline MBD4 deficiency causes a multi-tumor predisposition syndrome (2022, The American Journal of Human Genetics)
  • Pan-Cancer Interrogation of MUTYH Variants Reveals Biallelic Inactivation and Defective Base Excision Repair Across a Spectrum of Solid Tumors (2024, JCO Precision Oncology)
  • Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes (2024, Nature Communications)
  • A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients (2021, European Journal of Cancer)

Frequent co-authors collaborating with Cheadle include:

  • Tim Maughan
  • Claire Palles
  • Richard Kaplan
  • Rachel Kerr
  • David Kerr

The publication venues where Cheadle most frequently publishes include:

  • Nature Genetics
  • International Journal of Cancer
  • The American Journal of Human Genetics
  • JCO Precision Oncology
  • Nature Communications

Best Publications

  • Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

    Marjon van Slegtenhorst;Ronald de Hoogt;Caroline Hermans;Mark Nellist

  • Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors

    Nada Al-Tassan;Nikolas H. Chmiel;Julie Helen Maynard;Nick Fleming

  • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial

    Timothyn Stanley Maughan;Richard Alexander Adams;Chris Smith;Angela M. Meade

  • Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

    Russell G. Snell;John C. MacMillan;Jeremy Peter Cheadle;Iain Fenton

  • Mismatch Repair Status and BRAF Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies

    Sabine Venderbosch;Iris D Nagtegaal;Timothy S Maughan;Christopher G Smith

  • Interaction Between Hamartin and Tuberin, the TSC1 and TSC2 Gene Products

    Marjon van Slegtenhorst;Mark Nellist;Bas Nagelkerken;Jeremy Cheadle

  • Comprehensive Mutation Analysis of TSC1 and TSC2—and Phenotypic Correlations in 150 Families with Tuberous Sclerosis

    Alistair C. Jones;Magitha M. Shyamsundar;Meinir W. Thomas;Julie Helen Maynard

  • Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH

    Julian Roy Sampson;Sunil Dolwani;Sian Jones;Diana Eccles

  • Molecular genetic advances in tuberous sclerosis

    Jeremy Peter Cheadle;Mary Pat Reeve;Julian Roy Sampson;David J. Kwiatkowski

  • Renal cystic disease in tuberous sclerosis: role of the polycystic kidney disease 1 gene

    Julian R. Sampson;Magitha M. Maheshwar;Richard Aspinwall;Peter Thompson

  • Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

    Richard S Houlston;Jeremy Peter Cheadle;Sara E. Dobbins;Albert Tenesa

  • Population variation of common cystic fibrosis mutations

    Jeremy Peter Cheadle

  • Optimal Temperature Selection for Mutation Detection by Denaturing HPLC and Comparison to Single-Stranded Conformation Polymorphism and Heteroduplex Analysis

    Alistair C. Jones;Jehannine Austin;Nancy Hansen;Bastiaan Hoogendoorn

  • Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III.

    Richard Aspinwall;Dominic G. Rothwell;Teresa Roldan-Arjona;Catherine Anselmino

  • Long-read sequence analysis of the MECP2 gene in Rett syndrome patients: correlation of disease severity with mutation type and location

    Jeremy Peter Cheadle;Harinder Gill;Nick Fleming;Julie Helen Maynard

  • Molecular Genetic and Phenotypic Analysis Reveals Differences between TSC1 and TSC2 Associated Familial and Sporadic Tuberous Sclerosis

    Alistair C. Jones;Claire E. Daniells;Russell G. Snell;Maria Tachataki

  • The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

    Giovanna Benvenuto;Shaowei Li;Samantha J. Brown;Richard Braverman

  • Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

    Malcolm G Dunlop;Sara E Dobbins;Susan Mary Farrington;Angela M Jones

  • Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer

    Ian P. M. Tomlinson;Luis G. Carvajal-Carmona;Sara E. Dobbins;Albert Tenesa

  • Association analyses identify 31 new risk loci for colorectal cancer susceptibility

    P J Law;M Timofeeva;C Fernandez-Rozadilla;P Broderick

Frequent Co-Authors

Julian Roy Sampson
Julian Roy Sampson Cardiff University
Richard S. Houlston
Richard S. Houlston Institute of Cancer Research
Malcolm G. Dunlop
Malcolm G. Dunlop University of Edinburgh
Ian Tomlinson
Ian Tomlinson University of Oxford
David J. Kerr
David J. Kerr University of Oxford
Lauri A. Aaltonen
Lauri A. Aaltonen University of Helsinki
Graham Casey
Graham Casey University of Virginia
Mark A. Jenkins
Mark A. Jenkins University of Melbourne
David V. Conti
David V. Conti University of Southern California
Daniel D. Buchanan
Daniel D. Buchanan University of Melbourne

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