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Genetics

D-Index
84
Citations
42149
World Ranking
1338
National Ranking
634

Overview

James A. Knowles is affiliated with Rutgers, The State University of New Jersey in the United States. Their research spans multiple disciplines within medicine and biology, with a strong focus on genetics, molecular biology, and cardiovascular medicine.

Their main fields of study include Medicine and Biochemistry, Genetics and Molecular Biology. More specifically, their work covers key subfields such as Molecular Biology, Surgery, Genetics, Endocrinology, Diabetes and Metabolism, and Cardiology and Cardiovascular Medicine.

The scientist's research addresses several main topics, highlighted by extensive publications in areas including Lipoproteins and Cardiovascular Health, Diabetes, Cardiovascular Risks, and Lipoproteins, Genetic Associations and Epidemiology, Adipose Tissue and Metabolism, Health Systems, Economic Evaluations, Quality of Life, Metabolism, Diabetes, and Cancer, as well as Liver Disease Diagnosis and Treatment.

Recent publications include:

  • A guide for the diagnosis of rare and undiagnosed disease: beyond the exome (2022), published in Genome Medicine
  • Ultrarapid Nanopore Genome Sequencing in a Critical Care Setting (2022), published in New England Journal of Medicine
  • Mitochondrial Dysfunction, Insulin Resistance, and Potential Genetic Implications (2020), published in Endocrinology
  • The Clinical Genome Resource (ClinGen) Familial Hypercholesterolemia Variant Curation Expert Panel consensus guidelines for LDLR variant classification (2021), published in Genetics in Medicine
  • Properties of structural variants and short tandem repeats associated with gene expression and complex traits (2020), published in Nature Communications

The scientist frequently collaborates with other researchers, including:

  • Ivan Carcamo-Orive
  • Thomas Quertermous
  • Fahim Abbasi
  • Martin Wabitsch
  • Robert A. Hegele

James A. Knowles has published numerous papers in prominent venues such as:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Circulation
  • UNC Libraries
  • Nature Communications

Best Publications

  • Biological insights from 108 schizophrenia-associated genetic loci

    Stephan Ripke;Stephan Ripke;Benjamin M. Neale;Benjamin M. Neale;Aiden Corvin;James T. R. Walters

  • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

    S. Hong Lee;Stephan Ripke;Stephan Ripke;Benjamin M. Neale;Benjamin M. Neale;Stephen V. Faraone

  • Analysis of shared heritability in common disorders of the brain

    Verneri Anttila;Verneri Anttila;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Hilary K. Finucane;Raymond K. Walters;Raymond K. Walters

  • Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

    Niamh Mullins;Andreas J. Forstner;Andreas J. Forstner;Andreas J. Forstner;Kevin S. O'Connell;Kevin S. O'Connell;Brandon Coombes

  • Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene.

    Zemin Deng;Jane H. Morse;Susan L. Slager;Nieves Cuervo

  • Transcriptional landscape of the prenatal human brain

    Jeremy A. Miller;Song Lin Ding;Susan M. Sunkin;Kimberly A. Smith

  • Comprehensive functional genomic resource and integrative model for the human brain

    Daifeng Wang;Daifeng Wang;Shuang Liu;Jonathan Warrell;Hyejung Won

  • Integrative functional genomic analysis of human brain development and neuropsychiatric risks

    Mingfeng Li;Gabriel Santpere;Yuka Imamura Kawasawa;Yuka Imamura Kawasawa;Oleg V Evgrafov

  • Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

    Douglas M. Ruderfer;Stephan Ripke;Stephan Ripke;Stephan Ripke;Andrew McQuillin;James Boocock

  • Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

    Colm O'Dushlaine;Lizzy Rossin;Phil H. Lee;Laramie Duncan;Laramie Duncan

  • Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

    Alexander Gusev;S. Hong Lee;Gosia Trynka;Hilary Finucane

  • Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis

    Paul D. Arnold;Kathleen D. Askland;Cristina Barlassina;Laura Bellodi

  • The PsychENCODE project

    Schahram Akbarian;Chunyu Liu;James A Knowles;Flora M Vaccarino

  • Genome-wide association study of obsessive-compulsive disorder.

    S. E. Stewart;D. Yu;J. M. Scharf;B. M. Neale

  • Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies

    Dongmei Yu;Jae Hoon Sul;Fotis Tsetsos;Muhammad S Nawaz

  • Genetic homogeneity between acute and chronic forms of spinal muscular atrophy.

    T C Gilliam;L M Brzustowicz;L H Castilla;T Lehner

  • Partitioning the heritability of tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

    Lea K. Davis;Dongmei Yu;Clare L. Keenan;Eric R. Gamazon

  • Genome-wide association study of recurrent early-onset major depressive disorder.

    J Shi;J. B. Potash;J. A. Knowles;M. M. Weissman

  • Genetic basis of pulmonary arterial hypertension: current understanding and future directions.

    John H Newman;Richard C Trembath;Jane A Morse;Ekkehard Grunig

  • Investigation of serotonin-related genes in antidepressant response

    E. J. Peters;S. L. Slager;P. J. McGrath;J. A. Knowles

Frequent Co-Authors

Abby J. Fyer
Abby J. Fyer Columbia University
Myrna M. Weissman
Myrna M. Weissman Columbia University
Susan E. Hodge
Susan E. Hodge Columbia University
Gerald Nestadt
Gerald Nestadt Johns Hopkins University School of Medicine
Dan J. Stein
Dan J. Stein University of Cape Town
Yin Yao Shugart
Yin Yao Shugart National Institutes of Health
Steven A. Rasmussen
Steven A. Rasmussen Brown University
Douglas F. Levinson
Douglas F. Levinson Stanford University
Carlos N. Pato
Carlos N. Pato Rutgers, The State University of New Jersey
Donald F. Klein
Donald F. Klein New York University

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