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Chemistry

D-Index
121
Citations
64729
World Ranking
470
National Ranking
202

Research.com Recognitions

  • 1990 - Oesper Award, University of Cincinnati and American Chemical Society
  • 1987 - NAS Award in Chemical Sciences, National Academy of Sciences (US) For his studies of organoboranes, which revealed important new chemistry and established them as versatile intermediates in synthesis.
  • 1982 - Perkin Medal, Society of Chemical Industry, American Section
  • 1981 - Priestley Medal, American Chemical Society (ACS)
  • 1979 - Nobel Prize for their development of the use of boron- and phosphorus-containing compounds, respectively, into important reagents in organic synthesis
  • 1969 - US President's National Medal of Science "For discovery and exploration of the hydroboration reaction and for developing it into a major and powerful tool in chemical synthesis.", Presented by President Nixon at a White House Ceremony on February 16, 1970.
  • 1968 - Linus Pauling Award, American Chemical Society (ACS)
  • 1959 - William H. Nichols Medal, American Chemical Society (ACS)
  • 1958 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1957 - Member of the National Academy of Sciences
  • 1955 - Centenary Prize, Royal Society of Chemistry (UK)

Overview

Herbert C. Brown was affiliated with Purdue University West Lafayette in the United States. Throughout their career, they contributed significantly to the field of chemistry, particularly through the study and development of boron-containing compounds as reagents in organic synthesis.

Their work included pioneering studies on organoboranes that established these compounds as versatile intermediates in synthetic chemistry. This contribution helped shape the understanding and application of boron chemistry in practical and research contexts.

Over the course of their scientific career, Herbert C. Brown received multiple awards and honors recognizing their impact on chemistry. These included the Nobel Prize in 1979 for the development of boron- and phosphorus-containing compounds for use as reagents in organic synthesis. Other awards include the NAS Award in Chemical Sciences in 1987, given by the National Academy of Sciences for studies of organoboranes and their synthetic applications, and the US President's National Medal of Science in 1969, awarded for the discovery and exploration of the hydroboration reaction.

Additional notable awards include the Oesper Award from the University of Cincinnati and the American Chemical Society in 1990, the Perkin Medal from the Society of Chemical Industry, American Section in 1982, the Priestley Medal from the American Chemical Society in 1981, and the Linus Pauling Award in 1968. Earlier in their career, they were recognized with the William H. Nichols Medal in 1959, became a Fellow of the American Association for the Advancement of Science in 1958, were elected a Member of the National Academy of Sciences in 1957, and received the Centenary Prize from the Royal Society of Chemistry in 1955.

Herbert C. Brown's research legacy was marked by a focus on chemical synthesis methodologies involving boron compounds, influencing both academic research and practical applications in organic chemistry. Their scientific contributions persist through the continued use and study of reagents and reactions they helped to develop.

Best Publications

  • Sodium Borohydride, Its Hydrolysis and its Use as a Reducing Agent and in the Generation of Hydrogen1

    H. I. Schlesinger;Herbert C. Brown;A. E. Finholt;James R. Gilbreath

  • An Extended Table of Hammett Substitutent Constants Based on the Ionization of Substituted Benzoic Acids

    Darl H. McDANIEL;Herbert C. Brown

  • Asymmetric carbon-carbon bond formation via .beta.-allyldiisopinocampheylborane. Simple synthesis of secondary homoallylic alcohols with excellent enantiomeric purities

    Herbert C. Brown;Prabhakar K. Jadhav

  • Chiral synthesis via organoboranes. 6. Asymmetric allylboration via chiral allyldialkylboranes. Synthesis of homoallylic alcohols with exceptionally high enantiomeric excess

    Prabhakar K. Jadhav;Krishna S. Bhat;P. Thirumalai Perumal;Herbert C. Brown

  • Chiral synthesis via organoboranes. 7. Diastereoselective and enantioselective synthesis of erythro- and threo-.beta.-methylhomoallyl alcohols via enantiomeric (Z)- and (E)-crotylboranes

    Herbert C. Brown;Krishna S. Bhat

  • Chiral synthesis via organoboranes. 27. Remarkably rapid and exceptionally enantioselective (approaching 100% ee) allylboration of representative aldehydes at -100.degree. under new, salt-free conditions

    Uday S. Racherla;Herbert C. Brown

  • Enantiomeric Z- and E-crotyldiisopinocampheylboranes. Synthesis in high optical purity of all four possible stereoisomers of .beta.-methylhomoallyl alcohols

    Herbert C. Brown;Krishna S. Bhat

  • Chiral synthesis via organoboranes. 14. Selective reductions. 41. Diisopinocampheylchloroborane, an exceptionally efficient chiral reducing agent

    Herbert C. Brown;J. Chandrasekharan;P. V. Ramachandran

  • Forty years of hydride reductions

    Herbert C. Brown;S. Krishnamurthy

  • Lithium tri-sec-butylborohydride. New reagent for the reduction of cyclic and bicyclic ketones with super stereoselectivity. Remarkably simple and practical procedure for the conversion of ketones to alcohols in exceptionally high stereochemical purity

    Herbert C. Brown;S. Krishnamurthy

  • An Interpretation of the Chemical Behavior of Five- and Six-membered Ring Compounds1

    Herbert C. Brown;J. H. Brewster;H. Shechter

  • Organoboranes. 31. A simple preparation of boronic esters from organolithium reagents and selected trialkoxyboranes

    Herbert C. Brown;Thomas E. Cole

  • New, Highly Active Metal Catalysts for the Hydrolysis of Borohydride

    Herbert C. Brown;Charles A. Brown

  • Catecholborane (1,3,2-benzodioxaorole) as a new, general monohydroboration reagent for alkynes. Convenient synthesis of alkeneboronic esters and acids from alkynes via hydroboration

    Herbert C. Brown;S. K. Gupta

  • Hydroboration. IX. The Hydroboration of Cyclic and Bicyclic Olefins—Stereochemistry of the Hydroboration Reaction

    Herbert C. Brown;George Zweifel

  • Substituent Constants for Aromatic Substitution1-3

    Herbert C. Brown;Y. Okamoto

  • A SIMPLE PROCEDURE FOR THE CHROMIC ACID OXIDATION OF ALCOHOLS TO KETONES OF HIGH PURITY

    Herbert C. Brown;Chandra P. Garg

  • Reactions of Diborane with Alkali Metal Hydrides and Their Addition Compounds. New Syntheses of Borohydrides. Sodium and Potassium Borohydrides1

    H. I. Schlesinger;Herbert C. Brown;Henry R. Hoekstra;Louis R. Rapp

  • A Quantitative Treatment of Directive Effects in Aromatic Substitution

    Leon M. Stock;Herbert C. Brown

  • Hydroboration. XXXIX. 1,3,2-Benzodioxaborole (catecholborane) as a new hydroboration reagent for alkenes and alkynes. General synthesis of alkane- and alkeneboronic acids and esters via hydroboration. Directive effects in the hydroboration of alkenes and alkynes with catecholborane

    Herbert C. Brown;S. K. Gupta

Frequent Co-Authors

Bakthan Singaram
Bakthan Singaram University of California, Santa Cruz
Ei-ichi Negishi
Ei-ichi Negishi Purdue University West Lafayette
George Zweifel
George Zweifel University of California, Davis
Deevi Basavaiah
Deevi Basavaiah University of Hyderabad
Akira Suzuki
Akira Suzuki Hokkaido University
Yoshinori Yamamoto
Yoshinori Yamamoto Tohoku University
George W. Kabalka
George W. Kabalka University of Tennessee at Knoxville
Norio Miyaura
Norio Miyaura Hokkaido University
Paul v. R. Schleyer
Paul v. R. Schleyer University of Georgia
Norman Davidson
Norman Davidson California Institute of Technology

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