World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
97
Citations
37537
World Ranking
1453
National Ranking
559

Research.com Recognitions

  • 2014 - Member of the National Academy of Sciences
  • 2011 - Fellow of the American Academy of Arts and Sciences
  • 2010 - Nobel Prize for palladium-catalyzed cross couplings in organic synthesis
  • 1986 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Ei-ichi Negishi was affiliated with Purdue University West Lafayette in the United States. Their research work spanned multiple fields, primarily focusing on Chemistry with an emphasis on Organic Chemistry, Materials Chemistry, and intersections with Health Information Management, Artificial Intelligence, and Information Systems.

The main topics addressed in their research included:

  • Artificial Intelligence in Healthcare
  • Data Stream Mining Techniques
  • Artificial Intelligence and Decision Support Systems
  • Organoboron and Organosilicon Chemistry
  • Catalytic C-H Functionalization Methods
  • Catalytic Cross-Coupling Reactions
  • Big Data Technologies and Applications

Among the notable publications by Ei-ichi Negishi were:

  • Fuzzy Logic Systems for Healthcare Applications, 2024, Journal of Biomedical and Sustainable Healthcare Applications
  • Chemo- and Stereoselective Dearomative Coupling of Indoles and Bielectrophilic β-Imino Boronic Esters via Imine-Induced 1,2-Boronate Migration, 2021, Organic Letters
  • A Review of Basic Analytics, Medical Data Sources, and Advanced Data Analytics in the Medical Sector, 2024, Journal of Biomedical and Sustainable Healthcare Applications
  • CCDC 2102759: Experimental Crystal Structure Determination, 2021, The Cambridge Structural Database

The frequent coauthors collaborating with Ei-ichi Negishi included Xiaoping Fu, Qingqing Qi, Shiqing Xu, and Akira Suzuki. These collaborations contributed to work published in venues such as the Journal of Biomedical and Sustainable Healthcare Applications, Organic Letters, and The Cambridge Structural Database.

Throughout their career, Ei-ichi Negishi received multiple recognitions, including the Nobel Prize in 2010 for palladium-catalyzed cross couplings in organic synthesis. Additional honors included election as a Fellow of the American Academy of Arts and Sciences in 2011, membership in the National Academy of Sciences in 2014, and a fellowship at the John Simon Guggenheim Memorial Foundation in 1986.

Best Publications

  • Handbook of organopalladium chemistry for organic synthesis

    Ei-ichi Negishi

  • Palladium-catalyzed alkynylation.

    Ei Ichi Negishi;Luigi Anastasia

  • Palladium- or nickel-catalyzed cross coupling. A new selective method for carbon-carbon bond formation

    Eiichi Negishi

  • Selective carbon-carbon bond formation via transition metal catalysis. 3. A highly selective synthesis of unsymmetrical biaryls and diarylmethanes by the nickel- or palladium-catalyzed reaction of aryl- and benzylzinc derivatives with aryl halides

    Eiichi Negishi;Anthony O. King;Nobuhisa Okukado

  • Magical power of transition metals: past, present, and future (Nobel Lecture).

    Ei-ichi Negishi

  • CYCLIC CARBOPALLADATION. A VERSATILE SYNTHETIC METHODOLOGY FOR THE CONSTRUCTION OF CYCLIC ORGANIC COMPOUNDS

    Ei-ichi Negishi;Christophe Copéret;Shengming Ma;and Show-Yee Liou

  • Reaction of zirconocene dichloride with alkyllithiums or alkyl grignard reagents as a convenient method for generating a “zirconocene” equivalant and its use in zirconium-promoted cyclization of alkenes, alkynes, dienes, enynes, and diynes☆

    Ei-ichi Negishi;Fredrik E Cederbaum;Tamotsu Takahashi

  • Highly general stereo-, regio-, and chemo-selective synthesis of terminal and internal conjugated enynes by the Pd-catalysed reaction of alkynylzinc reagents with alkenyl halides

    Anthony O. King;Nobuhisa Okukado;Ei-ichi Negishi

  • Metal-promoted cyclization. 19. Novel bicyclization of enynes and diynes promoted by zirconocene derivatives and conversion of zirconabicycles into bicyclic enones via carbonylation

    Eiichi Negishi;Steven J. Holmes;James M. Tour;Joseph A. Miller

  • Recent advances in efficient and selective synthesis of di-, tri-, and tetrasubstituted alkenes via Pd-catalyzed alkenylation-carbonyl olefination synergy.

    Ei-ichi Negishi;Zhihong Huang;Guangwei Wang;Swathi Mohan

  • Patterns of Stoichiometric and Catalytic Reactions of Organozirconium and Related Complexes of Synthetic Interest

    Ei-Ichi Negishi;Tamotsu Takahashi

  • Palladium-catalyzed cross-coupling reaction of homoallylic or homopropargylic organozincs with alkenyl halides as a new selective route to 1,5-dienes and 1,5-enynes

    Eiichi Negishi;Louis F. Valente;Makoto Kobayashi

  • A novel stereospecific alkenyl-alkenyl cross-coupling by a palladium- or nickel-catalyzed reaction of alkenylalanes with alkenyl halides

    Shigeru Baba;Eiichi Negishi

  • Palladium- or nickel-catalyzed reactions of alkenylmetals with unsaturated organic halides as a selective route to arylated alkenes and conjugated dienes: scope, limitations, and mechanism

    E. Negishi;T. Takahashi;S. Baba;D.E. Van Horn

  • Selective carbon-carbon bond formation via transition metal catalysts. 9. Double metal catalysis in the cross-coupling reaction and its application to the stereo- and regioselective synthesis of trisubstituted olefins

    Eiichi Negishi;Nobuhisa Okukado;Anthony O. King;David E. Van Horn

  • Selective carbon-carbon bond formation via transition metal catalysts. 8. Controlled carbometalation. Reaction of acetylenes with organoalane-zirconocene dichloride complexes as a route to stereo- and regio-defined trisubstituted olefins

    David E. Van Horn;Eiichi Negishi

  • Organometallics in organic synthesis

    Ei-ichi Negishi

  • Transition Metal-Catalyzed Organometallic Reactions that Have Revolutionized Organic Synthesis

    Ei-ichi Negishi

  • Palladium-catalyzed acylation of organozincs and other organometallics as a convenient route to ketones☆

    Ei-ichi Negishi;Vhid Bagheri;Sugata Chatterjee;Fen-Tair Luo

  • Controlled carbometalation. 20. Carbometalation reaction of alkynes with organoalene-zirconocene derivatives as a route to stereo-and regiodefined trisubstituted alkenes

    Eiichi Negishi;David E. Van Horn;Tadao Yoshida

Frequent Co-Authors

Tamotsu Takahashi
Tamotsu Takahashi Hokkaido University
Herbert C. Brown
Herbert C. Brown Purdue University West Lafayette
James M. Tour
James M. Tour Rice University
Martin Kotora
Martin Kotora Charles University
Noriyuki Suzuki
Noriyuki Suzuki National Institute for Environmental Studies
Frédéric Lamaty
Frédéric Lamaty University of Montpellier
Kazunari Akiyoshi
Kazunari Akiyoshi Kyoto University
Andrew Pelter
Andrew Pelter Swansea University
Keith Smith
Keith Smith University of Edinburgh

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