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Biology and Biochemistry

D-Index
57
Citations
13306
World Ranking
13704
National Ranking
57

Overview

David E. MacHugh is affiliated with University College Dublin in Ireland. Their primary research activities span the fields of Biochemistry, Genetics and Molecular Biology, with 77 publications, and Medicine, comprising 37 publications. Within these broader disciplines, their work has focused on specialized subfields such as Genetics, Molecular Biology, Epidemiology, Cancer Research, and Infectious Diseases.

The researcher's main topics of work include genetic and phenotypic traits in livestock, Mycobacterium research and diagnosis, cancer-related molecular mechanisms research, tuberculosis research and epidemiology, veterinary equine medical research, genetic mapping and diversity in plants and animals, as well as RNA modifications and cancer.

Some of the frequent venues where David E. MacHugh has published include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Tuberculosis
  • Frontiers in Immunology
  • PLoS ONE
  • iScience

The researcher has frequently collaborated with other scientists in their field, including:

  • Gillian P. McHugo
  • Thomas J. Hall
  • John A. Browne
  • Emmeline W. Hill
  • James A. Ward

Among their recent publications are several papers that address genetics and veterinary research topics:

  • Genomic inbreeding trends, influential sire lines and selection in the global Thoroughbred horse population, 2020, Scientific Reports
  • Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations, 2022, iScience
  • Common protein-coding variants influence the racing phenotype in galloping racehorse breeds, 2022, Communications Biology
  • Selection signatures for local and regional adaptation in Chinese Mongolian horse breeds reveal candidate genes for hoof health, 2023, BMC Genomics
  • Identification of novel molecular markers of mastitis caused by Staphylococcus aureus using gene expression profiling in two consecutive generations of Chinese Holstein dairy cattle, 2020, Journal of Animal Science and Biotechnology

This body of work reflects a focus on livestock genetics, disease markers, and molecular biology applied to veterinary science and animal breeding. The scientist's research portfolio contributes to understanding genetic diversity, adaptation, and disease mechanisms in both equine and bovine populations across various geographical contexts.

Best Publications

  • Evidence for two independent domestications of cattle

    Ronan T. Loftus;David E. MacHugh;Daniel G. Bradley;Paul M. Sharp

  • Genetic evidence for Near-Eastern origins of European cattle

    Christopher S. Troy;David E. MacHugh;Jillian F. Bailey;David A. Magee

  • Mitochondrial diversity and the origins of African and European cattle

    Daniel G. Bradley;David E. MacHugh;Patrick Cunningham;Ronan T. Loftus

  • Microsatellite DNA Variation and the Evolution, Domestication and Phylogeography of Taurine and Zebu Cattle (Bos taurus and Bos indicus)

    David E. MacHugh;Mark D. Shriver;Ronan T. Loftus;Patrick Cunningham

  • Prehistoric genomes reveal the genetic foundation and cost of horse domestication

    Mikkel Schubert;Hakon Jonsson;Dan Chang;Clio Der Sarkissian

  • Genetic structure of seven European cattle breeds assessed using 20 microsatellite markers

    D. E. MacHugh;R. T. Loftus;P. Cunningham;D. G. Bradley

  • Livestock genetic origins: Goats buck the trend

    David E. MacHugh;Daniel G. Bradley

  • A microsatellite survey of cattle from a centre of origin: the Near East

    Ronan T. Loftus;O. Ertuğrul;A. H. Harba;M.A.A. El-Barody

  • A Sequence Polymorphism in MSTN Predicts Sprinting Ability and Racing Stamina in Thoroughbred Horses

    Emmeline W Hill;Jingjing Gu;Suzanne S Eivers;Rita G Fonseca

  • Circulating microRNAs as Potential Biomarkers of Infectious Disease.

    Carolina N. Correia;Nicolas C. Nalpas;Kirsten E. McLoughlin;John A. Browne

  • Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle.

    Stephen D E Park;David A. Magee;David A. Magee;Paul A. McGettigan;Matthew D. Teasdale

  • Phylogenetic analysis of the tribe Bovini using microsatellites.

    L R Ritz;M L Glowatzki-Mullis;D E MacHugh;C Gaillard

  • Microsatellite DNA variation within and among European cattle breeds

    David E. Machugh;Ronan T. Loftus;Daniel G. Bradley;Paul M. Sharp

  • A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses

    Emmeline W Hill;Beatrice A McGivney;Jingjing Gu;Ronan Whiston

  • Genetics and domestic cattle origins

    Daniel G. Bradley;Ronan T. Loftus;Patrick Cunningham;David E. MacHugh

  • A genome scan for positive selection in thoroughbred horses.

    Jingjing Gu;Nick Orr;Nick Orr;Stephen D. Park;Lisa M. Katz

  • Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent.

    Marta Pereira Verdugo;Victoria E. Mullin;Victoria E. Mullin;Amelie Scheu;Amelie Scheu;Valeria Mattiangeli

  • Zebu-taurine variation in Y chromosomal DNA: a sensitive assay for genetic introgression in West African trypanotolerant cattle populations

    D G Bradley;D E MacHugh;R T Loftus;R S Sow

  • Mitochondrial genetic variation in European, African and Indian cattle populations.

    Loftus Rt;MacHugh De;Ngere Lo;Balain Ds

  • Taming the Past: Ancient DNA and the Study of Animal Domestication

    David E. MacHugh;Greger Larson;Ludovic Orlando;Ludovic Orlando

Frequent Co-Authors

Daniel G. Bradley
Daniel G. Bradley Trinity College Dublin
Stephen V. Gordon
Stephen V. Gordon University College Dublin
Eamonn Gormley
Eamonn Gormley University College Dublin
Donagh P. Berry
Donagh P. Berry Teagasc - The Irish Agriculture and Food Development Authority
Charles Spillane
Charles Spillane University of Galway
Sinéad M. Waters
Sinéad M. Waters Teagasc - The Irish Agriculture and Food Development Authority
Karsten Hokamp
Karsten Hokamp Trinity College Dublin
Cliona O'Farrelly
Cliona O'Farrelly Trinity College Dublin
Ross D Evans
Ross D Evans Wageningen University & Research
Nick Orr
Nick Orr Queen's University Belfast

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