World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
18629
World Ranking
6968
National Ranking
533

Overview

David A. Matthews is affiliated with the University of Bristol in the United Kingdom. Their research is primarily situated within the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with notable work in subfields such as Infectious Diseases, Molecular Biology, Animal Science and Zoology, Epidemiology, and Immunology.

The main topics covered by their research include:

  • SARS-CoV-2 and COVID-19 Research
  • Animal Virus Infections Studies
  • Viral gastroenteritis research and epidemiology
  • Respiratory viral infections research
  • Virus-based gene therapy research
  • Interferon and immune responses
  • Viral Infections and Immunology Research

Their recent significant publications demonstrate an emphasis on SARS-CoV-2 viral mechanisms and transmission. Papers include:

  • "Neuropilin-1 is a host factor for SARS-CoV-2 infection" (2020) published in Science
  • "The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets" (2021) published in Nature Microbiology
  • "Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein" (2020) published in Genome Medicine
  • "Neuropilin-1 is a host factor for SARS-CoV-2 infection" (2020) published in bioRxiv (Cold Spring Harbor Laboratory)
  • "The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells" (2020) published in bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors in their work are:

  • Andrew D. Davidson
  • Julian A. Hiscox
  • Maia Kavanagh Williamson
  • Miles W. Carroll
  • Xiaofeng Dong

Matthews has published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Genome Medicine, Viruses, and the Journal of Virology. The highest volume of publications appears in preprint servers and open repositories, reflecting ongoing contributions to virology and infectious disease research.

Best Publications

  • Real-time, portable genome sequencing for Ebola surveillance

    Joshua Quick;Nicholas J. Loman;Sophie Duraffour;Jared T. Simpson;Jared T. Simpson

  • Neuropilin-1 is a host factor for SARS-CoV-2 infection.

    James L. Daly;Boris Simonetti;Katja Klein;Kai En Chen

  • Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.

    J T Bolin;D J Filman;D A Matthews;R C Hamlin

  • Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase

    Jay F. Davies;Zuzana Hostomska;Zdenek Hostomsky;Steven R. Jordan

  • The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets.

    Thomas P. Peacock;Daniel H. Goldhill;Jie Zhou;Laury Baillon

  • Virus genomes reveal factors that spread and sustained the Ebola epidemic

    Gytis Dudas;Gytis Dudas;Luiz Max Carvalho;Trevor Bedford;Andrew J. Tatem

  • Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein.

    Andrew D Davidson;Maia Kavanagh Williamson;Sebastian D Lewis;Deborah K Shoemark

  • Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate.

    DA Matthews;RA Alden;JT Bolin;ST Freer

  • Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa

    Miles W. Carroll;David A. Matthews;Julian A. Hiscox;Michael J. Elmore

  • Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.

    D A Matthews;J T Bolin;J M Burridge;D J Filman

  • Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. II. Environment of bound NADPH and implications for catalysis.

    D J Filman;J T Bolin;D A Matthews;J Kraut

  • Crystal structure of avian dihydrofolate reductase containing phenyltriazine and NADPH.

    K W Volz;D A Matthews;R A Alden;S T Freer

  • X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state.

    D A Matthews;R A Alden;J J Birktoft;S T Freer

  • Neuropilin-1 is a host factor for SARS-CoV-2 infection

    James L. Daly;Boris Simonetti;Carlos Antón-Plágaro;Maia Kavanagh Williamson

  • Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase.

    Daniel R. Knighton;Chen-Chen Kan;Eleanor Howland;Cheryl A. Janson

  • Adenovirus core protein V interacts with p32--a protein which is associated with both the mitochondria and the nucleus.

    D A Matthews;W C Russell

  • Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex.

    D A Matthews;R A Alden;J T Bolin;D J Filman

  • The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation.

    Svend K. Petersen-Mahrt;Camilla Estmer;Christina Öhrmalm;David A. Matthews

  • Identification of variable domains of the attachment (G) protein of subgroup A respiratory syncytial viruses.

    P A Cane;David A Matthews;C R Pringle

  • De novo derivation of proteomes from transcriptomes for transcript and protein identification

    Vanessa C Evans;Gary L A Barker;Kate J Heesom;Jun Fan

Frequent Co-Authors

Julian A. Hiscox
Julian A. Hiscox University of Liverpool
Andrew D. Davidson
Andrew D. Davidson University of Bristol
Miles W. Carroll
Miles W. Carroll University of Oxford
Lisa F. P. Ng
Lisa F. P. Ng Agency for Science, Technology and Research
James P. Stewart
James P. Stewart University of Liverpool
Georgios Pollakis
Georgios Pollakis University of Liverpool
Eric W.F.W. Alton
Eric W.F.W. Alton National Institutes of Health
Stephan Günther
Stephan Günther Bernhard Nocht Institute for Tropical Medicine
Yee Sin Leo
Yee Sin Leo Nanyang Technological University
Patricia A. Cane
Patricia A. Cane Public Health England

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