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D-Index & Metrics

Genetics

D-Index
58
Citations
23050
World Ranking
3294
National Ranking
1436

Overview

Christopher D. Brown was affiliated with the University of Pennsylvania in the United States. Their research spanned fields including Biochemistry, Genetics and Molecular Biology, with a total of 66 publications, and Medicine with 31 works. Within these domains, their subfields of study included Genetics, Molecular Biology, Radiology, Nuclear Medicine and Imaging, Physiology, and Insect Science.

The main topics explored in their research encompassed Genetic Associations and Epidemiology, Bioinformatics and Genomic Networks, RNA Research and Splicing, Alzheimer's disease research and treatments, Epigenetics and DNA Methylation, Genomics and Chromatin Dynamics, and RNA modifications and cancer.

Christopher D. Brown contributed research to various scientific venues, notably publishing multiple papers in Alzheimer's & Dementia (11 publications), Genome Biology (6), bioRxiv (Cold Spring Harbor Laboratory) (6), Nature Genetics (3), and Zenodo (CERN European Organization for Nuclear Research) (2).

Their notable recent papers included:

  • Exploiting the GTEx resources to decipher the mechanisms at GWAS loci, 2021, Genome Biology
  • Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease, 2022, Nature Genetics
  • Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease, 2021, Cell
  • A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation, 2022, Nature Genetics
  • Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments, 2021, Nature Genetics

Coauthorship was frequent with several researchers across these studies, including Struan F.A. Grant (10 publications), François Aguet (9), Kristin Ardlie (8), Benjamin F. Voight (8), and Alvaro Barbeira (7).

Best Publications

  • The GTEx Consortium atlas of genetic regulatory effects across human tissues

    F Aguet;AN Barbeira;R Bonazzola;A Brown

  • Genetic effects on gene expression across human tissues.

    Enhancing GTEx (eGTEx) groups

  • Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE

    Sushmita Roy;Jason Ernst;Peter V. Kharchenko;Pouya Kheradpour

  • Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.

    Alvaro N. Barbeira;Scott P. Dickinson;Rodrigo Bonazzola;Jiamao Zheng

  • Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas

    Tanguy Y Seiwert;Zhixiang Zuo;Michaela K Keck;Arun Khattri

  • A Cis-Regulatory Map of the Drosophila Genome

    Nicolas Nègre;Christopher D. Brown;Lijia Ma;Christopher Aaron Bristow

  • A Quantitative Proteome Map of the Human Body.

    Lihua Jiang;Meng Wang;Shin Lin;Ruiqi Jian

  • Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes

    Michaela K. Keck;Michaela K. Keck;Zhixiang Zuo;Arun Khattri;Thomas P. Stricker

  • A Comprehensive Map of Insulator Elements for the Drosophila Genome

    Nicolas Nègre;Christopher D. Brown;Parantu K. Shah;Pouya Kheradpour

  • Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue

    Federico Innocenti;Gregory M. Cooper;Ian B. Stanaway;Eric R. Gamazon

  • A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

    Lara M. Mangravite;Barbara E. Engelhardt;Barbara E. Engelhardt;Marisa W. Medina;Joshua D. Smith

  • Exploiting the GTEx resources to decipher the mechanisms at GWAS loci.

    Alvaro N. Barbeira;Rodrigo Bonazzola;Eric R. Gamazon;Yanyu Liang

  • Transposable elements are the primary source of novelty in primate gene regulation.

    Marco Trizzino;Yo Son Park;Marcia Holsbach-Beltrame;Katherine Aracena

  • Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.

    Suzanne Vogelezang;Suzanne Vogelezang;Jonathan P Bradfield;Tarunveer S Ahluwalia;John A Curtin

  • Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease

    Chengxiang Qiu;Shizheng Huang;Jihwan Park;Yo Son Park

  • Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs.

    Christopher D. Brown;Lara M. Mangravite;Barbara E. Engelhardt

  • The GTEx Consortium atlas of genetic regulatory effects across human tissues

    François Aguet;Alvaro N Barbeira;Rodrigo Bonazzola;Andrew Brown

  • CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia.

    Megan E. McNerney;Christopher D. Brown;Xiaoyue Wang;Elizabeth T. Bartom

  • Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data

    Yong Tao;Jue Ruan;Shiou-Hwei Yeh;Xuemei Lu

  • A Comprehensive Map of Insulator Elements for the Drosophila Genome

    Kevin P. White;Steven Henikoff;Lincoln Stein;Robert A. H. White

Frequent Co-Authors

Kevin P. White
Kevin P. White National University of Singapore
Xiaoquan Wen
Xiaoquan Wen University of Michigan–Ann Arbor
Stephen B. Montgomery
Stephen B. Montgomery Stanford University
Kristin Ardlie
Kristin Ardlie Broad Institute
Struan F.A. Grant
Struan F.A. Grant University of Pennsylvania
Tuuli Lappalainen
Tuuli Lappalainen Royal Institute of Technology
Daniel J. Rader
Daniel J. Rader University of Pennsylvania
Eric R. Gamazon
Eric R. Gamazon Vanderbilt University Medical Center

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Best Scientists Citing Christopher D. Brown