His primary areas of investigation include Genetics, Copy-number variation, Autism, Human genome and Candidate gene. Many of his studies on Genetics apply to Autism spectrum disorder as well. Bradley P. Coe interconnects Genetic heterogeneity and Massive parallel sequencing in the investigation of issues within Copy-number variation.
His Autism research focuses on subjects like Intellectual disability, which are linked to Disease, Phenotype and Gene rearrangement. The Human genome study combines topics in areas such as Copy number analysis, Comparative genomic hybridization, Computational biology and Sequence assembly. Within one scientific family, Bradley P. Coe focuses on topics pertaining to Mutation under Candidate gene, and may sometimes address concerns connected to Sequence analysis and Molecular Inversion Probe.
Bradley P. Coe spends much of his time researching Genetics, Copy-number variation, Gene, Autism and Comparative genomic hybridization. His Genetics research focuses on Genome, Human genome, Gene duplication, Exome and Intellectual disability. The study incorporates disciplines such as Gene dosage and Computational biology in addition to Genome.
The various areas that Bradley P. Coe examines in his Copy-number variation study include Bioinformatics, Phenotype, Penetrance, Haploinsufficiency and Disease. His Autism research is multidisciplinary, incorporating perspectives in Mutation, Proband, Genetic heterogeneity and Candidate gene. His Comparative genomic hybridization research includes elements of genomic DNA, DNA, Molecular biology and Bacterial artificial chromosome.
Bradley P. Coe mainly investigates Genetics, Copy-number variation, Gene, Phenotype and Autism. His study in Genetics concentrates on Missense mutation, Human genetics, Proband, Mutation and Candidate gene. His studies examine the connections between Proband and genetics, as well as such issues in Exome, with regards to Enteric nervous system and Penetrance.
His Copy-number variation study deals with Gene duplication intersecting with Human genome. The Haploinsufficiency research Bradley P. Coe does as part of his general Phenotype study is frequently linked to other disciplines of science, such as Sub clinical, therefore creating a link between diverse domains of science. He combines subjects such as GABRG2, Case-control study and Intellectual disability with his study of Autism.
The scientist’s investigation covers issues in Genetics, Autism, Phenotype, Gene and Copy-number variation. His study in Genetics focuses on Mutation and Human genetics. His research in Mutation intersects with topics in Neurodevelopmental disorder and Disease.
Bradley P. Coe has researched Human genetics in several fields, including Exome sequencing, Genome, Whole genome sequencing and Systems biology. His Autism study frequently draws connections between adjacent fields such as Proband. His work investigates the relationship between Phenotype and topics such as Candidate gene that intersect with problems in Exome.
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Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
Brian J. O’Roak;Laura Vives;Santhosh Girirajan;Emre Karakoc.
Genome structural variation discovery and genotyping
Can Alkan;Bradley P. Coe;Evan E. Eichler;Evan E. Eichler.
Nature Reviews Genetics (2011)
A copy number variation morbidity map of developmental delay
Gregory M Cooper;Bradley P Coe;Santhosh Girirajan;Jill A Rosenfeld.
Nature Genetics (2011)
Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.
Brian J. O’Roak;Laura Vives;Wenqing Fu;Jarrett D. Egertson.
A tiling resolution DNA microarray with complete coverage of the human genome.
Adrian S. Ishkanian;Chad A. Malloff;Spencer K. Watson;Ronald J. DeLeeuw.
Nature Genetics (2004)
Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development
Raphael Bernier;Christelle Golzio;Bo Xiong;Holly A. Stessman.
Copy number variation detection and genotyping from exome sequence data
Niklas Krumm;Peter H. Sudmant;Arthur Ko;Brian J. O'Roak.
Genome Research (2012)
Phenotypic Heterogeneity of Genomic Disorders and Rare Copy-Number Variants
Santhosh Girirajan;Jill A. Rosenfeld;Bradley P. Coe;Sumit Parikh.
The New England Journal of Medicine (2012)
A Higher Mutational Burden in Females Supports a “Female Protective Model” in Neurodevelopmental Disorders
Sébastien Jacquemont;Bradley P. Coe;Micha Hersch;Michael H. Duyzend.
American Journal of Human Genetics (2014)
Refining analyses of copy number variation identifies specific genes associated with developmental delay
Bradley P. Coe;Kali Witherspoon;Jill A. Rosenfeld;Bregje W M Van Bon;Bregje W M Van Bon.
Nature Genetics (2014)
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