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Bernard A.J. Roelen

Bernard A.J. Roelen

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
12309
World Ranking
16541
National Ranking
399

Overview

Bernard A.J. Roelen is affiliated with Utrecht University in the Netherlands and has contributed to research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans several subfields, notably Molecular Biology, Public Health, Environmental and Occupational Health, Genetics, Physiology, and Pediatrics, Perinatology and Child Health.

Their research interests focus extensively on topics such as Pluripotent Stem Cells Research, Reproductive Biology and Fertility, Biomedical Ethics and Regulation, Renal and related cancers, Epigenetics and DNA Methylation, Animal Genetics and Reproduction, and CRISPR and Genetic Engineering.

Bernard A.J. Roelen has published papers including the following:

  • Stay on the road: from germ cell specification to gonadal colonization in mammals, 2022, Philosophical Transactions of the Royal Society B Biological Sciences
  • The development of the amnion in mice and other amniotes, 2022, Philosophical Transactions of the Royal Society B Biological Sciences
  • Microinjection induces changes in the transcriptome of bovine oocytes, 2020, Scientific Reports
  • Cellular Fragments in the Perivitelline Space Are Not a Predictor of Expanded Blastocyst Quality, 2021, Frontiers in Cell and Developmental Biology
  • A reproductive science perspective: deliberations on the stem cell guidelines update, 2022, Molecular Human Reproduction

The scientist frequently collaborates with others, with notable coauthors including Christine L. Mummery, Anja van de Stolpe, Hans Clevers, Michele Boiani, and Susana M. Chuva de Sousa Lopes.

Their work has appeared repeatedly in venues such as Philosophical Transactions of the Royal Society B Biological Sciences, Molecular Human Reproduction, bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, and Frontiers in Cell and Developmental Biology.

In addition to journal publications, Bernard A.J. Roelen has contributed to the book Concepts and Applications of Stem Cell Biology, published by Springer International Publishing in 2020.

Best Publications

  • Bmp4 is required for the generation of primordial germ cells in the mouse embryo.

    K. A. Lawson;N. R. Dunn;B. A. J. Roelen;L. M. Zeinstra

  • Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist

    Rutger L. van Bezooijen;Bernard A.J. Roelen;Annemieke Visser;Lianne van der Wee-Pals

  • Natural Selection of Human Embryos: Impaired Decidualization of Endometrium Disables Embryo-Maternal Interactions and Causes Recurrent Pregnancy Loss

    Madhuri Salker;Gijs Teklenburg;Mariam Molokhia;Stuart Lavery

  • Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition

    Jan Willem Voncken;Bernard A. J. Roelen;Mieke Roefs;Stijn de Vries

  • Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures.

    Robert Passier;Dorien Ward‐van Oostwaard;Jolanda Snapper;Jantine Kloots

  • Natural Selection of Human Embryos: Decidualizing Endometrial Stromal Cells Serve as Sensors of Embryo Quality upon Implantation

    Gijs Teklenburg;Madhuri S. Salker;Mariam Molokhia;Stuart Lavery

  • DNA damage in bovine sperm does not block fertilization and early embryonic development but induces apoptosis after the first cleavages.

    A N Fatehi;M M Bevers;E Schoevers;B A J Roelen

  • Oleic Acid Prevents Detrimental Effects of Saturated Fatty Acids on Bovine Oocyte Developmental Competence

    Hilde Aardema;Peter L.A.M. Vos;Francesca Lolicato;Bernard A.J. Roelen

  • The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos

    Ewart W. Kuijk;Leni T. A. van Tol;Hilde Van de Velde;Richard Wubbolts

  • Controlling mesenchymal stem cell differentiation by TGFΒ family members

    Bernard A.J. Roelen;Peter ten Dijke

  • BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo

    Susana M. Chuva de Sousa Lopes;Bernard A.J. Roelen;Rui M. Monteiro;Roul Emmens

  • Differences in early lineage segregation between mammals.

    Ewart W. Kuijk;Leonie Du Puy;Helena T.A. Van Tol;Christine H.Y. Oei

  • Differences in the incidence of apoptosis between in vivo and in vitro produced blastocysts of farm animal species: a comparative study.

    F.J. Rubio Pomar;K.J. Teerds;A. Kidson;B. Colenbrander

  • Piwi Proteins and piRNAs in Mammalian Oocytes and Early Embryos

    Elke F. Roovers;David Rosenkranz;Mahdi Mahdipour;Chung-Ting Han

  • Initiation, establishment and maintenance of Hox gene expression patterns in the mouse.

    J Deschamps;E van den Akker;S Forlani;W De Graaff

  • Expression of growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), and BMP receptors in the ovaries of goats.

    J.R.V. Silva;R. van den Hurk;H.T.A. van Tol;B.A.J. Roelen

  • DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells.

    J. P. De Winter;B. A. J. Roelen;P. Ten Dijke;B. Van Der Burg

  • Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and angiogenesis in early mouse development

    Bernard A.J. Roelen;Marga A. van Rooijen;Christine L. Mummery

  • Validation of reference genes for quantitative RT-PCR studies in porcine oocytes and preimplantation embryos

    Ewart W Kuijk;Leonie du Puy;Helena T A van Tol;Henk P Haagsman

  • Exposure of Oocytes to the Fusarium Toxins Zearalenone and Deoxynivalenol Causes Aneuploidy and Abnormal Embryo Development in Pigs

    Hassan Malekinejad;Eric J. Schoevers;Ineke J.J.M. Daemen;Carla Zijlstra

Frequent Co-Authors

Ben Colenbrander
Ben Colenbrander Utrecht University
Susana Lopes
Susana Lopes Leiden University Medical Center
Henk P. Haagsman
Henk P. Haagsman Utrecht University
Bart M. Gadella
Bart M. Gadella Utrecht University
Christine L. Mummery
Christine L. Mummery Leiden University Medical Center
Willem Stoorvogel
Willem Stoorvogel Utrecht University
Nick S. Macklon
Nick S. Macklon University of Copenhagen
Johanna Fink-Gremmels
Johanna Fink-Gremmels Utrecht University
Peter M. Lansdorp
Peter M. Lansdorp University of British Columbia
Marie-José Goumans
Marie-José Goumans Leiden University Medical Center

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