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Adriana Di Polo

Adriana Di Polo

D-Index & Metrics

Neuroscience

D-Index
44
Citations
7424
World Ranking
7179
National Ranking
423

Overview

Adriana Di Polo is affiliated with the University of Montreal in Canada and has contributed extensively to the fields of medicine, biochemistry, genetics and molecular biology, and neuroscience. Their research primarily focuses on retinal development and disorders, glaucoma and retinal disorders, as well as neurological conditions and treatments. Other topics of interest include mitochondrial function and pathology, neuroscience and neuropharmacology research, and barrier structure and function studies.

The scientist's work has been published frequently in venues such as Molecular Neurodegeneration, Acta Ophthalmologica, Progress in Retinal and Eye Research, Ophthalmology Science, and bioRxiv (Cold Spring Harbor Laboratory). The range of journals reflects a strong presence in molecular and ophthalmologic research communities.

Notable recent papers include:

  • Interpericyte tunnelling nanotubes regulate neurovascular coupling (2020), published in Nature
  • Solving neurodegeneration: common mechanisms and strategies for new treatments (2022), published in Molecular Neurodegeneration
  • Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering (2023), published in Molecular Aspects of Medicine
  • Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma (2022), published in Proceedings of the National Academy of Sciences
  • AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma (2021), published in Molecular Neurodegeneration

Their collaborations include frequent co-authors such as Nicolás Belforte, Heberto Quintero, Florence Dotigny, Yukihiro Shiga, and Deborah Villafranca-Baughman. These collaborations indicate a network of researchers working on overlapping subjects related to neurodegenerative diseases, ophthalmology, and molecular mechanisms of neural and retinal disorders.

Adriana Di Polo's research spans multiple subfields within broader scientific areas, with a particular emphasis on:

  • Molecular Biology
  • Ophthalmology
  • Neurology
  • Cellular and Molecular Neuroscience
  • Radiology, Nuclear Medicine and Imaging

Best Publications

  • The molecular basis of retinal ganglion cell death in glaucoma.

    Mohammadali Almasieh;Ariel M. Wilson;Barbara Morquette;Jorge Luis Cueva Vargas

  • Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells

    A Di Polo;L J Aigner;R J Dunn;G M Bray

  • The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

    Przemyslaw Sapieha;Mirna Sirinyan;Mirna Sirinyan;David Hamel;Karine Zaniolo

  • TrkB Gene Transfer Protects Retinal Ganglion Cells from Axotomy-Induced Death In Vivo

    Li Cheng;Przemyslaw Sapieha;Pavla Kittlerová;William W. Hauswirth

  • Interpericyte tunnelling nanotubes regulate neurovascular coupling.

    Luis Alarcon-Martinez;Deborah Villafranca-Baughman;Heberto Quintero;J. Benjamin Kacerovsky

  • Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection.

    Luis Alarcon-Martinez;Luis Alarcon-Martinez;Sinem Yilmaz-Ozcan;Muge Yemisci;Jesse Schallek

  • Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism.

    Frédéric Lebrun-Julien;Laure Duplan;Vincent Pernet;Ingrid Osswald

  • Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo

    Vincent Pernet;Adriana Di Polo

  • Mitochondrial dynamics, transport, and quality control: A bottleneck for retinal ganglion cell viability in optic neuropathies.

    Yoko A. Ito;Adriana Di Polo

  • Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury.

    Przemyslaw S Sapieha;Martin Peltier;Katherine G Rendahl;William C Manning

  • Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer's disease.

    Marius Chiasseu;Luis Alarcon-Martinez;Nicolas Belforte;Heberto Quintero

  • ProNGF induces TNFα-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway

    Frédéric Lebrun-Julien;Mathieu J. Bertrand;Olivier De Backer;David Stellwagen

  • Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae.

    Seiji B. Shibata;Sarah R. Cortez;Lisa A. Beyer;James A. Wiler

  • Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

    Jorge L. Cueva Vargas;Ingrid K. Osswald;Nicolas Unsain;Mark R. Aurousseau

  • Drug and gene delivery to the back of the eye: from bench to bedside.

    Cheryl L. Rowe-Rendleman;Shelley A. Durazo;Uday B. Kompella;Kay D. Rittenhouse

  • Tau Accumulation, Altered Phosphorylation, and Missorting Promote Neurodegeneration in Glaucoma

    Marius Chiasseu;Jorge L. Cueva Vargas;Laurie Destroismaisons;Christine Vande Velde

  • Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury

    Jessica Agostinone;Luis Alarcon-Martinez;Clare Gamlin;Wan-Qing Yu

  • Activation of the Extracellular Signal-Regulated Kinase 1/2 Pathway by AAV Gene Transfer Protects Retinal Ganglion Cells in Glaucoma

    Yu Zhou;Vincent Pernet;William W. Hauswirth;Adriana Di Polo

  • Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS.

    Przemyslaw S. Sapieha;Laure Duplan;Noriko Uetani;Sandrine Joly

  • Four-kilobase sequence of the mouse CNP gene directs spatial and temporal expression of lacZ in transgenic mice

    M. Gravel;A. Di Polo;P.B. Valera;P.E. Braun

  • Inhibition of p75NTR in glia potentiates TrkA-mediated survival of injured retinal ganglion cells

    Frédéric Lebrun-Julien;Barbara Morquette;Annie Douillette;H. Uri Saragovi

Frequent Co-Authors

Wyeth W. Wasserman
Wyeth W. Wasserman University of British Columbia
Richard Robitaille
Richard Robitaille University of Montreal
Timothy E. Kennedy
Timothy E. Kennedy Montreal Neurological Institute and Hospital
Turgay Dalkara
Turgay Dalkara Bilkent University
Melanie E. M. Kelly
Melanie E. M. Kelly Dalhousie University
Elizabeth M. Simpson
Elizabeth M. Simpson University of British Columbia
Robert K. Koenekoop
Robert K. Koenekoop McGill University Health Centre
Bryan E. Pfingst
Bryan E. Pfingst University of Michigan–Ann Arbor
Yehoash Raphael
Yehoash Raphael University of Michigan–Ann Arbor
Nicholas C. Brecha
Nicholas C. Brecha University of California, Los Angeles

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